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Preparation method of low-corrosion-rate bio-functionalized coating for pure magnesium surface

It is a technology of biological functionalization and corrosion rate, which can be used in coatings, metal material coating processes, tissue regeneration and other directions. The effect of convenience and low preparation cost

Active Publication Date: 2017-06-13
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these existing coating technologies have problems such as complicated operation, strict requirements, unstable structure after modification, and easy loss of bioactive molecules.

Method used

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  • Preparation method of low-corrosion-rate bio-functionalized coating for pure magnesium surface
  • Preparation method of low-corrosion-rate bio-functionalized coating for pure magnesium surface
  • Preparation method of low-corrosion-rate bio-functionalized coating for pure magnesium surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of preparation method of pure magnesium surface biological functionalization coating with low corrosion rate, and its steps are:

[0023] A, adding the NaOH solution of 1mol / L to the aminotrimethylidene phosphonic acid solution with a concentration of 2.5mmol / L to obtain a modified solution with a pH value of 7;

[0024] B. Soak pure magnesium in a NaOH solution with a temperature of 60° C. and a concentration of 3 mol / L for 24 hours to obtain alkali-activated pure magnesium;

[0025] C, soak the pure magnesium after alkali activation in the modification solution of A step, be warmed up to 60 ℃, be incubated for 12 hours; Obtain the pure magnesium with aminotrimethylene phosphonic acid coating on the surface;

[0026] D, the pure magnesium with aminotrimethylene phosphonic acid coating on the surface prepared in step C is put into a magnesium sulfate solution with a concentration of 0.5mol / L and soaked for 2 hours, namely, a layer of corrosion rate is obtained on...

Embodiment 2

[0030] A kind of preparation method of pure magnesium surface biological functionalization coating with low corrosion rate, and its steps are:

[0031] A, adding the NaOH solution of 1mol / L to the aminotrimethylidene phosphonic acid solution with a concentration of 5mmol / L to obtain a modified solution with a pH value of 9;

[0032] B. Soak pure magnesium in a NaOH solution with a temperature of 65°C and a concentration of 3 mol / L for 18 hours to obtain alkali-activated pure magnesium;

[0033] C, soak the pure magnesium after alkali activation in the modification solution, heat up to 80 ℃, and keep the temperature for 17 hours; obtain the pure magnesium with aminotrimethyleneidene phosphonic acid coating on the surface;

[0034] D. The pure magnesium with aminotrimethylene phosphonic acid coating on the surface prepared in step C is put into a magnesium sulfate solution with a concentration of 0.5mol / L and soaked for 1.5 hours, that is, a layer of corrosion rate is obtained o...

Embodiment 3

[0038] A kind of preparation method of pure magnesium surface biological functionalization coating with low corrosion rate, and its steps are:

[0039] A, adding the NaOH solution of 1 mol / L to the aminotrimethylidene phosphonic acid solution with a concentration of 10 mmol / L to obtain a modified solution with a pH value of 5;

[0040] B. Soak pure magnesium in a NaOH solution with a temperature of 55°C and a concentration of 3 mol / L for 12 hours to obtain alkali-activated pure magnesium;

[0041] C, soak the pure magnesium after alkali activation in the modification solution, heat up to 50 ℃, and keep the temperature for 24 hours; obtain the pure magnesium with aminotrimethyleneidene phosphonic acid coating on the surface;

[0042] D, the pure magnesium with aminotrimethylene phosphonic acid coating on the surface obtained in step C is put into a magnesium sulfate solution with a concentration of 0.5mol / L and soaked for 1 hour, that is, a layer of corrosion rate is obtained o...

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Abstract

The invention discloses a preparation method of a low-corrosion-rate bio-functionalized coating for a pure magnesium surface. The preparation method comprises the following steps: A, an NaOH solution with concentration of 1 mol / L is added to an aminotris(methylenephosphonic acid)solution with concentration of2.5-10 mmol / L, and a modified solution with pH being 5-9 is obtained; B, pure magnesium is soaked in an NaOH solution with concentration of 1-6 mol / L for 12-24 h, and alkali activated pure magnesium is obtained; C, alkali activated pure magnesium is soaked in the modified solution, and the solution is heated to 50-80 DEG C and thetemperature is kept for 12-24 h; pure magnesium with an aminotris(methylenephosphonic acid) coating on the surface is obtained; D, prepared pure magnesium with the aminotris(methylenephosphonic acid) coating on the surface in the step C is soaked in a magnesium sulfate solution with concentration of 0.5 mol / L for 1-2 h, and the bio-functionalized coating with low corrosion rate is obtained on the pure magnesium surface. The bio-functionalized coating prepared with the method has good biocompatibility and low corrosion rate.

Description

technical field [0001] The invention relates to a preparation method of a pure magnesium surface biological functionalized coating. Background technique [0002] Magnesium is easily corroded and degradable in vivo, and the magnesium ions generated by degradation can be absorbed by human tissues or eliminated from the body through metabolism. At the same time, magnesium ions can participate in physiological activities as a cofactor related to energy metabolism, and the elastic modulus of magnesium is close to that of human bones, which has good mechanical compatibility. Therefore, magnesium has been widely used in the field of bone tissue repair as a biological implant material, and has a good application prospect in the application of vascular stent materials. However, due to the high chemical activity of magnesium, when it is implanted into the human body as an implant material, it is easily corroded by the surrounding physiological environment, causing it to lose its mech...

Claims

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Application Information

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IPC IPC(8): C23C22/08C23C22/60C23C22/68A61L27/04A61L27/28A61L27/50
CPCA61L27/047A61L27/28A61L27/50A61L2430/02C23C22/08C23C22/60C23C22/68
Inventor 万国江屈艾蒲世民张文泰李薇唐欣刘启军黄楠
Owner SOUTHWEST JIAOTONG UNIV
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