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Coenzyme Q10 glucose injection and preparation method thereof

A technology for glucose injection and glucose solution, which can be applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as poor stability of injections

Inactive Publication Date: 2017-06-16
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Injection has the disadvantage of poor stability

Method used

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  • Coenzyme Q10 glucose injection and preparation method thereof
  • Coenzyme Q10 glucose injection and preparation method thereof
  • Coenzyme Q10 glucose injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Ingredients prescription: coenzyme Q10, polysorbate 80, polyethylene glycol 15-hydroxystearate, 5% glucose solution.

[0024] Packaging material: 2ml brown ampoule.

[0025] prescription:

[0026] Coenzyme Q10 5g

[0027] Polysorbate 80 50g

[0028] Polyethylene glycol 15-hydroxystearate 20g

[0029] Add 5% glucose solution to 2000ml

[0030] A total of 1000 pieces were made

[0031] Preparation:

[0032] (1) Heat the 5% glucose solution to 50°C and keep it for later use.

[0033] (2) Heat and mix the prescribed amount of polysorbate 80 and polyethylene glycol 15-hydroxystearate in a water bath at 50°C, then add the prescribed amount of coenzyme Q10 and melt in the mixed solvent until clarified.

[0034] (3) Add 5% glucose solution to the mixture in step (2), stir evenly until the solution is clear, and keep warm at 50°C for 30 minutes.

[0035] (4) Filter the above solution while it is hot with a 0.2 μm filter membrane, and adjust the pH to be between 3.9 and...

Embodiment 2

[0038] prescription:

[0039] Coenzyme Q10 5g

[0040] Polysorbate 80 20g

[0041] Polyethylene glycol 15-hydroxystearate 50g

[0042] Add 5% glucose solution to 2000ml

[0043] A total of 1000 pieces were made

[0044] Preparation:

[0045] (1) Heat the 5% glucose solution to 50°C and keep it for later use.

[0046] (2) Heat and mix the prescribed amount of polysorbate 80 and polyethylene glycol 15-hydroxystearate in a water bath at 50°C, then add the prescribed amount of coenzyme Q10 and melt in the mixed solvent until clarified.

[0047] (3) Add 5% glucose solution to the mixture in step (2), stir evenly until the solution is clear, and keep warm at 50°C for 30 minutes.

[0048] (4) Filter the above solution while it is hot with a 0.2 μm filter membrane, and adjust the pH to be between 3.9 and 4.3.

[0049] (5) Fill, seal, and sterilize at 100°C for 30 minutes, and the product is ready.

Embodiment 3

[0051] prescription:

[0052] Coenzyme Q10 5g

[0053] Polysorbate 80 20g

[0054] Propylene glycol 25g

[0055] Polyethylene glycol 15-hydroxystearate 5g

[0056] Add 5% glucose solution to 2000ml

[0057] A total of 1000 pieces were made

[0058] Preparation:

[0059] (1) Heat the propylene glycol and 5% glucose solution to 50°C and keep it for later use.

[0060] (2) Heat and mix the prescribed amount of polysorbate 80 and polyethylene glycol 15-hydroxystearate in a water bath at 50°C, then add the prescribed amount of coenzyme Q10 and melt in the mixed solvent until clarified.

[0061] (3) Add propylene glycol and 5% glucose solution to the mixture in step (2), stir evenly until the solution is clear, and keep warm at 50°C for 30 minutes.

[0062] (4) Filter the above solution while it is hot with a 0.2 μm filter membrane, and adjust the pH to be between 3.9 and 4.3.

[0063] (5) Fill, seal, and sterilize at 100°C for 30 minutes, and the product is ready.

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Abstract

The invention discloses a coenzyme Q10 glucose injection and a preparation method thereof. The injection is composed of, by weight, 1-10 parts of coenzyme Q10, 20-80 parts of polysorbate 80, 1-50 parts of a solubilizer, and 400-4000 parts of a 5% glucose solution. In the invention, the solubilizer is matched with the Tween-80 so as to achieve solubilization to the coenzyme Q10. By means of the preparation method, the coenzyme Q10 glucose injection has stable quality and solves a problem of medicine separation-out within the range of period of validity.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a coenzyme Q10 glucose injection and a preparation method thereof. Background technique [0002] Coenzyme Q10 is soluble in chloroform, benzene, acetone, ethanol or petroleum ether, slightly soluble in ethanol, and insoluble in water. Coenzyme Q10 (CoenzymeQ10) was discovered in the precedent body of bovine heart in 1957. In 1974, a Japanese company made it into tablets for the treatment of mild heart failure, coronary heart disease, hypertension, and arrhythmia. After 1990, CoQ10 was widely used in nutrition, food, and cosmetic additives, and was used in high doses for the treatment of Parkinson's and Huntington's disease. my country began to produce raw materials and tablets of CoQ10 in the 1980s. Due to its large molecular weight and strong lipophilicity, oral administration is slow in gastrointestinal absorption and low in bioavailability, thus affectin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/122A61K47/26A61P9/04A61P9/10A61P9/12A61P9/06A61P25/16A61P25/14
CPCA61K9/0019A61K9/08A61K31/122A61K47/14A61K47/26
Inventor 曾培安郑和校吴健民张静
Owner KAMP PHARMA
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