Preparation method and application of copper sulphide nano-material

A nanomaterial and nanocomposite material technology, which is applied in the field of preparation of BSA-CuS nanocomposite materials, can solve the problems of ecosystem hazards, non-degradability of graphene oxide and unknown toxicity, high cost, and cost limitations, and achieves low bactericidal dose, Low pressure and low cost effect

Inactive Publication Date: 2017-06-23
QUANZHOU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the disadvantage of silver nanoparticles is that once exposed to air or water, silver ions begin to be slowly released into the environment and undergo chemical and biological transformations, causing great harm to the ec

Method used

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  • Preparation method and application of copper sulphide nano-material
  • Preparation method and application of copper sulphide nano-material
  • Preparation method and application of copper sulphide nano-material

Examples

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Embodiment 1

[0029] A preparation method of BSA-CuS nanocomposite material, comprising the following steps:

[0030] (1) Add 5 ml of 10 mM Cu(NO 3 ) 2 The solution was added to 5 mL bovine serum albumin BSA solution with a concentration of 5 mg / mL, and stirred at room temperature for 30 min to obtain a BSA-Cu suspension in which BSA-Cu conjugates were formed, and the color of the solution was light blue.

[0031] (2) Adjust the pH of the BSA-Cu suspension obtained in step (1) to 3.0 with a 95% nitric acid solution, add 0.5ml of a 0.5 M thioacetamide solution, and the solution becomes pale after shaking. yellow. The above solution was placed in a constant temperature water bath at 90 °C for natural incubation for 1 h to prepare BSA-CuS nanocomposites.

Embodiment 2

[0033] The BSA-CuS nanocomposite material gained in embodiment one is carried out TEM characterization, the result is as follows figure 1 As shown, the average particle size of CuS nanoparticles is around 50 nm.

Embodiment 3

[0035] The BSA-CuS nanocomposite obtained in Example 1 was subjected to ultraviolet spectrum detection before and after near-infrared light irradiation, and the results figure 2 As shown, the prepared BSA-CuS nanocomposites have characteristic absorption peaks in the near-infrared region, indicating that the BSA-CuS nanocomposites synthesized by the present invention have stable photothermal conversion efficiency.

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Abstract

The invention discloses a preparation method for a copper sulphide nano-material with near infrared absorption performance and near infrared light sterilizing capacity of the copper sulphide nano-material to Escherichia coli and staphylococcus aureus, and belongs to the fields of metal nano-material preparation and biomedical application. The copper sulphide nano-material is synthesized by adopting a water bath method; the reaction conditions are mild; the method is simple; the copper sulphide nano-material which are uniform in particular sizes and high in dispersibility and have strong absorbing performance at about 1,000 nm is prepared successfully by regulating temperature, pH and protein using amount; under the irradiation of near infrared light of 980 nm, near infrared light can be effectively converted into heat energy by the material, so that the Escherichia coli and the staphylococcus aureus can be killed within several minutes; an alternative treatment mode can be provided for clinical treatment of skin diseases because of unique photo-thermal sterilizing capacity and low cost of the material.

Description

technical field [0001] The invention relates to the fields of metal nanomaterial preparation and biomedical application, in particular to a preparation method and application of a BSA-CuS nanocomposite material. Background technique [0002] Whether in medicine, food, public health or other fields, bacterial infection has become a challenge all over the world. According to incomplete statistics, the global food industry loses nearly 600 billion U.S. dollars every year due to bacterial contamination. On the other hand, many patients died of postoperative bacterial infection. According to the report of the World Health Organization (WHO), 2 million people in China die from bacterial infections every year. At present, antibiotics are still the main drugs used clinically to treat bacterial infections. It has a history of nearly 100 years since its discovery, and it can very effectively inhibit the growth and reproduction of bacteria. However, the extensive use, abuse and irr...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/42A61P31/04
CPCA61K9/5169A61K41/0052Y02A50/30
Inventor 杨大鹏周金飞刘明焕
Owner QUANZHOU NORMAL UNIV
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