Biflavone-zinc complexes as well as preparation method and application thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of zinc complexes and biflavones, which is applied in the field of bisflavone-zinc complexes and its preparation, can solve the problems that the research on the synthetic biological activity of bisflavone complexes has not been reported.
Inactive Publication Date: 2017-06-30
NANJING FORESTRY UNIV
View PDF2 Cites 5 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0006] However, so far, the research on the synthesis and biological activity of biflavone complexes has not been reported
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0039] Accurately weigh 53.8mg (0.1mmol) of Ame in a round bottom flask, dissolve it with 5mL of ethanol, accurately weigh 14.9mg (0.05mmol) of zinc nitrate hexahydrate, dissolve it with 5mL of ethanol, and add the zinc nitrate solution dropwise to the Ame solution , add ethanol-ammonia water (V / V, 3:1) solution dropwise to the reaction solution, adjust the pH to 6, keep the reaction at 30°C for 4-5h, a precipitate occurs, filter, wash with ethanol and water in turn, recrystallize with DMSO, The Ame-Zn complex was obtained by freeze-drying.
Embodiment 2
[0041] Accurately weigh 53.8 mg of Ame in a round bottom flask, dissolve it with 5 mL of 90% ethanol, accurately weigh 14.9 mg of zinc nitrate hexahydrate, dissolve it with 5 mL of 90% ethanol, add the zinc nitrate solution dropwise to the Ame solution, add to the reaction solution Add ethanol-sodium ethoxide solution dropwise to adjust the pH to 5, keep at 30°C for 4-5h to react, precipitate, filter, wash with ethanol and water successively, recrystallize in DMSO, and freeze-dry to obtain the Ame-Zn complex.
Embodiment 3
[0043] Accurately weigh 53.8mg of Ame in a round bottom flask, dissolve it with 5mL of methanol, accurately weigh 14.9mg of zinc nitrate hexahydrate, dissolve it with 5mL of methanol, add the zinc nitrate solution to the Ame solution dropwise, and add methanol dropwise to the reaction solution - Sodium methoxide solution, adjust the pH to 7, keep at 40°C for 3-4 hours to react, a precipitate occurs, filter, wash with methanol and water in sequence, recrystallize in DMSO, and freeze-dry to obtain the Ame-Zn complex.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses biflavone-zinc complexes as well as a preparation method and an application thereof. Amentoflavone is taken as a ligand, zinc ions are taken as central ions, amentoflavone-zinc complexes are obtained through a reaction, and structures of the complexes are characterized with infrared spectra, ultraviolet-visible absorption spectra and high-resolution mass spectra. Meanwhile, the anti-tumor activity and the anti-oxidation activity of the amentoflavone-zinc complexes are studied. An MTT method proves that the amentoflavone-zinc complexes have better anti-tumor activity which is higher than that of amentoflavone; a pyrogallol auto-oxidation method and an ABTS method prove that the anti-oxidation activity of the amentoflavone-zinc complexes is higher than that of amentoflavone. By means of forming of the amentoflavone-zinc complexes, the anti-tumor activity and the anti-oxidation activity of amentoflavone are improved, and the complexes are expected to be used for developing drugs.
Description
technical field [0001] The invention belongs to the technical fields of organic synthesis and medicine, and in particular relates to a biflavone-zinc complex and its preparation method and application. Background technique [0002] Biflavonoids are unique chemical components of gymnosperms, such as Ginkgo biloba and Selaginella, which have biological activities such as anti-oxidation, anti-inflammation, anti-virus, and anti-tumor. Among them, Amentoflavone (Amentoflavone, Ame) is a relatively common type of amentoflavone compounds, and its structural formula is as follows: [0003] [0004] Sun et al. found that amentoflavone increased the expression of anti-cancer genes by activating hPPARγ, thereby achieving the effect of inhibiting breast cancer cells and cervical cancer cells [Lee E., Shin S., Lee J. et al. Cytotoxic activities of amentoflavone against human Breast and cervical cancers are mediated by increasing of pten expression levels due to peroxisome proliferato...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more