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Magnetic nanoparticle, and preparation method and application thereof

A magnetic nanoparticle and nanoparticle technology, applied in the field of materials, can solve the problems of low product yield, easy agglomeration, weak contrast signal, etc.

Active Publication Date: 2017-07-04
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the above-mentioned MRI contrast materials prepared by existing methods have disadvantages such as poor crystallinity and / or weak contrast signals, and their preparation methods are mostly the oil phase method with high toxicity. In the human body, the contrast materials prepared by the above-mentioned oil-phase method all need to use amphiphilic molecules for further "oil-to-water" phase inversion treatment, but the existing phase inversion treatment often has the disadvantages of low product yield and easy agglomeration

Method used

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  • Magnetic nanoparticle, and preparation method and application thereof
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  • Magnetic nanoparticle, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0169] (1) Weigh 0.5406g ferric chloride hexahydrate and 0.2982g ferrous chloride tetrahydrate, and dissolve them in 40mL deionized aqueous solution under magnetic stirring at room temperature to obtain solution A for use;

[0170] (2) Add 20mL of 0.2M NaOH solution into solution A, and stir magnetically for 1 hour at 70°C;

[0171] (3) Magnetically separate and wash the above reaction liquid 4 times with deionized water to obtain about 0.22 g of the first ferrite 1;

[0172] (4) dissolving the first ferrite 1 obtained in step (3) in 90 mL of deionized aqueous solution;

[0173] (5) Measure 10 mL of glacial acetic acid (concentration ≥ 99.5%) and add it to the reaction solution obtained in step (4), shake it at 60 ° C for 5 h, then let it stand for 24 h and then magnetically stir it at 90 ° C for 2 h to obtain about 0.20 g of magnetic nano particle1;

[0174] (6) Add 20 ml of an aqueous solution containing 40 mg of polyethylene glycol to the product obtained in step (5), ult...

Embodiment 2

[0191] (1) Weigh 0.5406g ferric chloride hexahydrate and 0.2982g ferrous chloride tetrahydrate, and dissolve them in 40mL deionized aqueous solution under magnetic stirring at room temperature to obtain solution A for use;

[0192] (2) Add 20mL of 0.3M KOH solution into solution A, and stir magnetically for 1 hour at 37°C;

[0193] (3) Magnetically separate and wash the above reaction liquid 5 times with deionized water to obtain about 0.23 g of the first ferrite 2;

[0194] (4) dissolving the first ferrite 2 obtained in step (3) in 90 mL of deionized aqueous solution;

[0195] (5) Add 10 mL of hypochlorous acid (analytical pure) to the reaction solution obtained in step (4), shake at room temperature for 3 h, and let stand for 26 h to obtain about 0.07 g of magnetic nanoparticles 2;

[0196] (6) Add 20 ml of an aqueous solution containing 40 mg of polyethylene glycol to the product obtained in step (5), ultrasonically disperse for 20 min, and react with mechanical stirring f...

Embodiment 3

[0200] (1) Weigh 0.5406g ferric chloride hexahydrate and 0.2982g ferrous chloride tetrahydrate, and dissolve them in 40mL deionized aqueous solution under magnetic stirring at room temperature to obtain solution A for use;

[0201] (2) Add 40mL of 0.3M KOH solution into solution A, and stir magnetically for 1 hour at 60°C;

[0202] (3) Magnetically separate and wash the above reaction liquid 4 times with deionized water to obtain about 0.25 g of the first ferrite 3;

[0203] (4) dissolving the first ferrite 3 obtained in step (3) in 100 mL of deionized aqueous solution;

[0204] (5) Weigh 3.0 g of sodium borohydride and add it to the mixed solution obtained in step (4), put the obtained reaction solution in a water bath at 60° C. for aging treatment, the aging time is 48 hours, and obtain 0.07 g of magnetic nanoparticles 3;

[0205] (6) Add 20 ml of an aqueous solution containing 40 mg of polyethylene glycol to the product obtained in step (5), ultrasonically disperse for 20 ...

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Abstract

The invention relates to a magnetic nanoparticle, and a preparation method and application thereof. Specifically, the magnetic nanoparticle has the characteristics that 1) the magnetic nanoparticle is ferrite; 2) the magnetic nanoparticle has a particle size of 0.1 to 30 nm; 3) the relaxation rate r1 of the magnetic nanoparticle is no less than 1.2 m / M / s; 4) a ratio of a relaxation rate r2 to the relaxation rate r1 of the magnetic nanoparticle is no more than 3.5 and no less than 1.05; and 5) the T1 weighted signal intensity of 0.5mM of the magnetic nanoparticle is no less than 70. The invention also discloses the preparation method and application of the magnetic nanoparticle. When the magnetic nanoparticle is applied to magnetic resonance imaging, a high-quality MRI contrast agent with substantial and excellent imaging performance, high magnetosensitivity and rich T1 signals can be obtained, and the MRI contrast agent is improved in discovery and detection of tumors, cardio-cerebrovascular diseases and other serious diseases, so medical detection and treatment cost can be substantially lowered.

Description

technical field [0001] The invention relates to the field of materials, in particular to a magnetic nanoparticle and its preparation method and application. Background technique [0002] With the development of science and technology, medical imaging technology has developed rapidly, which plays a vital role in the early diagnosis and early treatment of major diseases such as cancer, cardiovascular and cerebrovascular diseases, and can greatly improve the cure rate of cancer patients, thereby Save more lives. [0003] At present, medical imaging technologies mainly include Positron Emission Tomography (PET), Computed Tomography (Computed Tomography, CT) and Magnetic Resonance Imaging (Magnetic resonance imaging, MRI). Among them, magnetic resonance imaging is to use the difference in signal intensity caused by the difference in proton density of different tissues in the body to realize imaging. The X-rays used have the advantages of high-energy radiation, which may cause D...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K47/02
CPCA61K47/02A61K49/1818A61K49/1845A61K49/186A61K49/1863
Inventor 吴爱国陈天翔马雪华邹瑞芬祖柏儿项灵超
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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