Environment-friendly multifunctional composite negative-pressure drain wound-protection sponge and preparation method thereof

An environmentally friendly, negative pressure drainage technology, applied in the field of medical negative pressure sponges, can solve the problems of wound granulation tissue growing into the cavity, secondary wound damage, easy drying and hardening, etc., to improve safety and biocompatibility Sexuality, preventing tissue adhesion, and reducing artificial effects

Active Publication Date: 2017-07-04
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, at present, PVA sponge or PU sponge cannot meet the clinical needs alone.
PVA sponge tends to become dry and hard during negative pressure drainage treatment. If the water is not replenished in time, it will cause discomfort to the patient and cause secondary damage to the wound due to the friction between the dry hard sponge and the wound during the patient's exercise; Hydrophobic characteristics, the water retention rate is not strong, can only rely on negative pressure to continuously attract seepage
And PVA sponge or PU sponge is used alone, because of its large porosity and intercommunication between the cavities, it will cause the wound granulation tissue to grow into the cavities. When the negative pressure is released, it will also cause secondary damage to the wound, resulting in bleeding

Method used

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  • Environment-friendly multifunctional composite negative-pressure drain wound-protection sponge and preparation method thereof
  • Environment-friendly multifunctional composite negative-pressure drain wound-protection sponge and preparation method thereof
  • Environment-friendly multifunctional composite negative-pressure drain wound-protection sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The raw materials of an environment-friendly multifunctional composite negative pressure drainage and wound protection sponge are prepared respectively according to the following ratios:

[0029]

[0030] Among them, the polymerization degree of polyvinyl alcohol is 80,000; the catalyst is stannous octoate; the surfactant is sodium lauryl sulfate; the water-based polyurethane prepolymer is polyester type.

[0031] Prepare an environment-friendly multifunctional composite negative pressure drainage wound protection sponge according to the following steps:

[0032] Step A: Dissolve PVA in purified water at 90-100°C and stir for 60-90 minutes to a colorless and transparent solution, then cool down to 50-60°C to obtain system a with a content of

[0033] Step B: Take 70% of system a, add water-based polyurethane prepolymer, surfactant and catalyst and stir rapidly for 1-10 minutes to obtain system b;

[0034] Step C: take medical vaseline and light paraffin oil for medi...

Embodiment 2

[0039] The raw materials of an environment-friendly multifunctional composite negative pressure drainage and wound protection sponge are prepared respectively according to the following ratios:

[0040]

[0041]

[0042] Wherein, the degree of polymerization of polyvinyl alcohol is 100,000; the catalyst is triethanolamine; the surfactant is sodium lauryl sulfate; the water-based polyurethane prepolymer is polyether type.

[0043] Prepare an environment-friendly multifunctional composite negative pressure drainage wound protection sponge according to the following steps:

[0044] Step A: Dissolve PVA in purified water at 90-100°C and stir for 60-90 minutes to a colorless and transparent solution, then cool down to 50-60°C to obtain system a with a content of

[0045] Step B: Take 65% of system a, add water-based polyurethane prepolymer, surfactant and catalyst and stir rapidly for 1-10 minutes to obtain system b;

[0046] Step C: take medical vaseline and light paraffin ...

Embodiment 3

[0051]The raw materials of an environment-friendly multifunctional composite negative pressure drainage and wound protection sponge are prepared respectively according to the following ratios:

[0052]

[0053]

[0054] Among them, the polymerization degree of polyvinyl alcohol is 120,000; the catalyst is pentamethyldiethylenetriamine; the surfactant is stearic acid; the water-based polyurethane prepolymer is polyolefin type.

[0055] Prepare an environment-friendly multifunctional composite negative pressure drainage wound protection sponge according to the following steps:

[0056] Step A: Dissolve PVA in purified water at 90-100°C and stir for 60-90 minutes to a colorless and transparent solution, then cool down to 50-60°C to obtain system a with a content of

[0057] Step B: Take 60% of system a, add water-based polyurethane prepolymer, surfactant and catalyst and stir rapidly for 1-10 minutes to obtain system b;

[0058] Step C: take medical vaseline and light para...

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Abstract

The invention discloses an environment-friendly multifunctional composite negative-pressure drain wound-protection sponge and a preparation method thereof. The sponge comprises the following components by mass percentage: 5-30% of polyvinyl alcohol, 10-30% of an aqueous polyurethane performed polymer, 0.1-1% of a catalyst, 0.02-0.5% of a surfactant, 5-10% of medical Vaseline, 5-10% of medical lightweight paraffin oil, 5-10% of sodium hyaluronate, and the balance of purifying water. The wound-protection sponge combines foaming technology general characteristics of PVA and PU, which organically combines the excellent performances of PVA and PU, by adding the sodium hyaluronate, sponge water absorption, water retention performance, water absorption rate of the sponge are increased, a supercritical CO2 foaming mode is used, and the chemical residue of the sponge is reduced, the sponge water absorption is increased by 22 times and more, the water retention performance is increased by 7-10 days, the water absorption rate of the sponge is increased by at least one time, which can reach 10-12 g / min.g, and the sponge has good antistick effect.

Description

technical field [0001] The invention relates to a medical negative pressure sponge, in particular to an environment-friendly multifunctional composite negative pressure drainage and wound protection sponge and a preparation method thereof. Background technique [0002] Negative pressure drainage therapy (NPWT, negative pressure wound therapy), also known as closed negative pressure drainage technology (VAC, vacuum-assisted closure), is to use a negative pressure suction device connected to a special wound dressing, intermittently or continuously on the wound surface A wound treatment method that generates subatmospheric pressure to promote wound healing. Negative pressure sealing drainage technology is currently widely used in the fields of burns, wound repair, and plastic surgery. It stimulates granulation growth and promotes wound healing through negative pressure. The curative effect is worthy of recognition. [0003] But at present, PVA sponge or PU sponge cannot meet t...

Claims

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Application Information

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IPC IPC(8): C08L29/04C08L75/06C08L75/08C08L75/04C08L5/08C08L91/06C08J9/12
CPCC08J9/122C08J2203/06C08J2203/08C08J2329/04C08J2375/08C08J2475/04C08J2475/06C08J2475/08C08L29/04C08L75/08C08L2203/14C08L2205/025C08L2205/035C08L75/06C08L5/08C08L91/06C08L75/04
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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