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Application of silkworm excrement sodium manganese chlorophyllin in preparation of drugs for treating chronic inflammation type anemia

A chlorophyll manganese sodium salt, chronic inflammation technology, applied in the direction of drug combination, antipyretic, anti-inflammatory agent, etc., can solve the problem of untreated chronic inflammatory anemia, etc., to improve blood routine level, improve binding force, increase body weight Effect

Inactive Publication Date: 2017-07-07
武汉联合药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chlorophyll manganese sodium salt of silkworm excrement is a manganese sodium salt formed by reacting chlorophyll extracted from silkworm feces with manganese salt, and replacing magnesium ions in the basic structure of chlorophyll with divalent manganese ions. Currently, there is no treatment for chronic inflammatory anemia literature reports

Method used

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  • Application of silkworm excrement sodium manganese chlorophyllin in preparation of drugs for treating chronic inflammation type anemia
  • Application of silkworm excrement sodium manganese chlorophyllin in preparation of drugs for treating chronic inflammation type anemia
  • Application of silkworm excrement sodium manganese chlorophyllin in preparation of drugs for treating chronic inflammation type anemia

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Experimental program
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Embodiment 1

[0020] The preparation of embodiment 1 silkworm excrement chlorophyll manganese sodium salt

[0021] 1) Rough extraction: grind the silkworm excrement, then add 4 times the weight of acetone to the powder, infiltrate for 2 hours, then perform seepage extraction, control the seepage rate to 3ml / min, collect the seepage, and recover the acetone to get a dark green color paste crude extract;

[0022] 2) Refining: Dissolving the above-mentioned crude extract with No. 120 gasoline and then going to the NKA-2 type macroporous adsorption resin column, and eluting with 50% ethanol (referring to containing 50 g of ethanol in 100 g of ethanol aqueous solution) and ethyl acetate successively, Discard the ethanol eluate, collect the ethyl acetate eluate, adjust the pH value of the ethyl acetate eluate to 3 with hydrochloric acid, let the layers stand, filter, discard the upper filtrate, and collect the filter residue;

[0023] 3) Saponification: Dissolve the filter residue with No. 120 g...

Embodiment 2

[0026] Example 2 Therapeutic effect of silkworm excrement chlorophyll manganese sodium salt on chronic inflammatory anemia model rats

[0027] 1. Experimental method

[0028] The blood routine, serum iron metabolism indicators and inflammatory factor levels of the rat model of rheumatoid arthritis (CFA) established by injecting Freund's complete adjuvant into the toes are all in line with the characteristics of chronic inflammatory anemia, so we use the method of injecting Freund's complete adjuvant to the rats. Anemia of chronic inflammatory disease (ACD) model was established with complete adjuvant.

[0029] 40 male Sprague-Dawley rats were divided into 5 groups with 8 rats in each group, weighing 150-200g. Free feeding and drinking water were kept in standard polypropylene cages, the temperature of the animal room was 21-24°C, the relative humidity was 58-62%, and the light time was 12 hours per day.

[0030] Experimental rats were administered and modeled: 8 rats in the ...

Embodiment 3

[0045] Example 3 Clinical therapeutic effect of silkworm excrement chlorophyll manganese sodium salt on chronic inflammatory anemia

[0046] In order to prove the therapeutic effect of this medicine, all kinds of chronic inflammatory anemia cases of selected cases take the medicine of the present invention and observe, take 30 days as a course of treatment, treat 2 courses of treatment, carry out system inspection respectively.

[0047] 1. The clinical effect of drugs on patients with hemodialysis inflammatory anemia

[0048] ⑴ General Information

[0049] Selected 82 patients with hemodialysis inflammatory anemia, including 35 males and 47 females, with an average age of (51.2±11.3) years old. The above medical records were confirmed by routine blood tests, C-reactive protein, hepcidin, serum ferritin, and total iron binding capacity.

[0050] ⑵ treatment method

[0051] Take 4 tablets of silkworm excrement chlorophyll manganese sodium salt tablets each time, 3 times a day; ...

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Abstract

The invention discloses application of silkworm excrement sodium manganese chlorophyllin in preparation of drugs for treating chronic inflammation type anemia. The silkworm excrement sodium manganese chlorophyllin can effectively inhibit expression of hepcidin and inflammatory factors to bring blood routine parameters, iron metabolism and the inflammatory factors of patients back to a normal level, so that inducements for the chronic inflammation type anemia are inhibited fundamentally, and clinical symptoms are improved obviously; side effect is small, and safety is high.

Description

technical field [0001] The invention relates to a new pharmaceutical application of silkworm excrement chlorophyll manganese sodium salt, especially the application in preparing medicine for treating chronic inflammatory anemia. Background technique [0002] Anemia caused by chronic diseases is the second major anemia after iron deficiency anemia. It is a mild to moderate anemia secondary to chronic infection, inflammation and malignant tumors, also known as chronic inflammatory anemia. The onset of chronic inflammatory anemia is characterized by an infection that lasts for more than 1-2 months, often accompanied by monocyte-macrophage iron deposition in blood indicators, a significant decrease in serum iron and total iron binding capacity, and an increase in serum ferritin content. [0003] Studies have found that the pathogenic mechanism of chronic inflammatory anemia is that inflammation causes an increase in the expression of hepcidin in the liver, and then hepcidin bind...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K31/407A61P7/06A61P29/00C07D487/22
CPCA61K33/32A61K35/63C07D487/22
Inventor 刘朝胜
Owner 武汉联合药业有限责任公司
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