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Preparation method of D-arabinose

A technology of arabinose and sugar solution, which is applied in the field of preparation of D-arabinose, can solve the problems of large subsequent processing load, large consumption of hydrogen peroxide, long reaction time, etc., and achieve the effects of reducing losses, saving raw material costs, and high selectivity

Inactive Publication Date: 2017-07-14
广西轻工业科学技术研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems of large consumption of hydrogen peroxide, low utilization rate, long reaction time, and large follow-up processing load in the prior art process, the present invention provides a preparation method of D-arabinose. The preparation method of the present invention has simple process and mild reaction conditions. The reaction speed is fast, the reaction efficiency is high, and the obtained D-arabinose has a purity of more than 98%, high quality, and good economic and social benefits.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of D-arabinose, comprising charging → ultrasonic collaborative preparation → decolorization → desalination → concentrated crystallization, the specific process steps are:

[0027] (1) Loading: Add 20Kg of 10% calcium gluconate solution into the ultrasonic reactor, then add ferrous sulfate, the amount of ferrous sulfate is 0.6% of the mass of gluconic acid, and heat up to 50°C;

[0028] (2) Ultrasonic collaborative preparation: Start the ultrasonic reactor, the ultrasonic sound energy density is 0.5w / mL, the ultrasonic frequency is 20KHz, stir, and add hydrogen peroxide with a mass fraction of 30%. The amount of hydrogen peroxide is twice the equivalent of gluconic acid. React at 50-60°C. The ultrasonic reactor is equipped with an online automatic temperature adjustment device. The adjustment method is: when the temperature of the sugar solution is ≤50°C, hydrogen peroxide is automatically added at a flow rate of 40mL / min. Reduce the flow speed once,...

Embodiment 2

[0033] A preparation method of D-arabinose, comprising charging → ultrasonic collaborative preparation → decolorization → desalination → concentrated crystallization, the specific process steps are:

[0034] (1) Loading: Add 25Kg of calcium gluconate solution with a mass concentration of 20% into the ultrasonic reactor, then add ferrous sulfate, the amount of ferrous sulfate is 1.0% of the mass of gluconic acid, and heat up to 50°C;

[0035](2) Ultrasonic collaborative preparation: Start the ultrasonic reactor, the ultrasonic sound energy density is 1.0w / mL, the ultrasonic frequency is 22KHz, stir, and add hydrogen peroxide with a mass fraction of 30%. The amount of hydrogen peroxide is 3 times the equivalent of gluconic acid. The reaction is carried out at 50-60°C. The ultrasonic reactor is equipped with an online automatic temperature adjustment device. The adjustment method is: when the temperature of the sugar liquid is ≤50°C, hydrogen peroxide is automatically added to the...

Embodiment 3

[0040] A preparation method of D-arabinose, comprising charging → ultrasonic collaborative preparation → decolorization → desalination → concentrated crystallization, the specific process steps are:

[0041] (1) Loading: Add 20Kg of calcium gluconate solution with a mass concentration of 25% into the ultrasonic reactor, then add ferrous sulfate, the amount of ferrous sulfate is 0.8% of the mass of gluconic acid, and heat up to 50°C;

[0042] (2) Ultrasonic collaborative preparation: start the ultrasonic reactor, the ultrasonic sound energy density is 1.5w / mL, the ultrasonic frequency is 25KHz, stir, and add hydrogen peroxide with a mass fraction of 30%. The amount of hydrogen peroxide is 2.5 times the equivalent of gluconic acid. The reaction is carried out at 50-60°C. The ultrasonic reactor is equipped with an online automatic temperature adjustment device. The adjustment method is: when the temperature of the sugar liquid is ≤50°C, hydrogen peroxide is automatically added, th...

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Abstract

The invention discloses a preparation method of D-arabinose. The preparation method comprises the following steps: loading; ultrasonic synergic preparation; decoloring; desalting; and concentration and crystallization. The preparation method specifically comprises the process steps: adding a calcium gluconate solution into an ultrasonic reactor, then adding ferrous sulfate, starting the ultrasonic reactor, and feeding hydrogen peroxide to react to obtain a D-arabinose coarse liquid; and performing activated carbon decoloring and ion exchange fiber desalting on the D-arabinose coarse liquid, and finally performing concentration and crystallization to obtain the D-arabinose. The preparation method disclosed by the invention is simple in process, mild in reaction condition, high in reaction speed and high in reaction efficiency, and the purity of the obtained D-arabinose reaches 98% above, the quality of the D-arabinose is excellent, and the D-arabinose has good economical and social benefits.

Description

technical field [0001] The invention belongs to the technical field of functional sugar production, and in particular relates to a preparation method of D-arabinose. Background technique [0002] D-arabinose is a pentose analogue of D-ribose and is an important reducing sugar. It is often used as an important intermediate or raw material for the synthesis of D-ribose, cytarabine, adenosine, and new nucleic acid drugs. D-arabinose is rare in nature and only exists in certain bacterial polysaccharides. At present, the industrialized production technology of D-arabinose is only mastered by very few enterprises, and it is in a monopoly position, which leads to the high price of D-arabinose and limited application. [0003] At present, the main method of D-arabinose synthesis is chemical synthesis, that is, calcium gluconate is oxidatively decarboxylated with hydrogen peroxide under the action of an iron catalyst to obtain D-arabinose. The reagent composed of ferrous ion or fe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/02C07H1/00C07H1/06
CPCC07H3/02C07H1/00C07H1/06
Inventor 王元春雷光鸿曹敏黄忠华梁智姜毅
Owner 广西轻工业科学技术研究院有限公司
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