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Nano-rod-like structure hydroxyapatite and preparation method thereof

A hydroxyapatite and nanorod-like technology, applied in nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of easy crystallization and growth, unable to form nanostructured materials, etc., and achieve good biodegradation performance and morphology. And the effect of controllable size and convenient operation

Active Publication Date: 2017-07-21
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the current literature has reported methods for synthesizing rod-shaped hydroxyapatite materials, most of them use direct addition of inorganic calcium salts and phosphates, so that in the initial stage of the reaction, the calcium ions and phosphate ions in the solution may be in a supersaturated state. Therefore, it is easy to crystallize and grow, but cannot form stable nanostructure materials
[0008] At present, there is no report on the direct use of organic phosphorus and organic calcium sources to synthesize nanorod-shaped hydroxyapatite materials by hydrothermal method

Method used

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  • Nano-rod-like structure hydroxyapatite and preparation method thereof
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Embodiment 1

[0024] At room temperature, 0.3 g creatine phosphate (C 4 h 8 N 3 o 5 PNa 2 4H 2 O) be dissolved in the deionized water of 40 milliliters of room temperature and form A liquid, 0.4g calcium lactate (CH 3 CHOHCOO 2 Ca·5H 2 O) Dissolve in 20 ml of deionized water at 60°C to form solution B. Take liquid A and liquid B and mix them, and after magnetically stirring for 20 minutes, transfer the clear mixed solution into a reaction kettle (capacity: 60 ml), and react at 180° C. for 6 hours. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain the following: figure 1 The hydroxyapatite material shown. The material is assembled from nanorods.

Embodiment 2

[0026] At room temperature, 0.3 g creatine phosphate (C 4 h 8 N 3 o 5 PNa 2 4H 2 O) be dissolved in the deionized water of 40 milliliters of room temperature and form A liquid, 0.4g calcium lactate (CH 3 CHOHCOO 2 Ca·5H 2 O) Dissolve in 20 ml of deionized water at 60°C to form solution B. Take liquid A and liquid B and mix them, and after magnetically stirring for 20 minutes, transfer the clear mixed solution into a reaction kettle (capacity: 60 ml), and react at 120° C. for 4 hours. After the reaction system was naturally cooled to room temperature, the product was taken out and centrifuged. The separated product was washed three times with deionized water, once with absolute ethanol, and dried in air at 60°C to obtain the following: figure 2 The hydroxyapatite material shown. The material is assembled from nanorods.

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Abstract

The present invention relates to the field of biomaterial preparation, and provides nano-rod-like structure hydroxyapatite and a preparation method thereof. According to the preparation method, calcium lactate is adopted as a calcium source, creatine phosphate is adopted as a phosphorus source, and a hydrothermal reaction is performed to prepare the nano-rod-like structure hydroxyapatite. According to the present invention, the nano-rod-like structure hydroxyapatite has controlled appearance and controlled size, can be used as the biomedical material in the fields of drug delivery, bone defect repair and the like, and has good application prospect; the nano-rod-like structure hydroxyapatite is prepared by using the hydrothermal method, such that the reaction controllability is good; and the preparation process is simple, the operation is convenient, the complicated and expensive equipment is not needed, and the method is expected to achieve the industrial production.

Description

technical field [0001] The invention belongs to the field of biological material preparation, and in particular relates to a hydroxyapatite material with a nanorod structure prepared by using organic calcium as a calcium source and phosphorus-containing biomolecules as a phosphorus source through a hydrothermal method. Background technique [0002] With the rapid development of transportation tools, bone defects caused by accidents have become one of the major problems threatening human life and health. When the bone defect exceeds a certain range, it cannot repair itself. Although autologous bone transplantation is currently a commonly used clinical treatment method, its application is limited due to the disadvantages of fewer sources and secondary trauma. Therefore, the method of using biomaterials to repair bone defects came into being. [0003] Hydroxyapatite is the most important inorganic component in human bones and teeth. The calcium and phosphorus contained in it ...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00B82Y30/00
CPCC01B25/32C01P2004/04C01P2004/16
Inventor 蔡筑韵钱齐荣
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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