Plastic slow-release microsphere scaffold material capable of supporting various drugs and preparation method thereof

Abstract

The invention relates to a plastic slow-release microsphere scaffold material from sodium alginate and chitosan and capable of supporting various drugs and a preparation method thereof, and belongs to the field of tissue-engineered bone scaffold materials. The plastic slow-release microsphere scaffold material is composed of slow-release microspheres and a loose porous sponge structure; both the slow-release microspheres and the loose porous sponge structure can support drugs; the slow-release microspheres are of 'sodium alginate-chitosan multilayer composite slow-release microsphere' multilayer spherical structure, sodium alginate serves as a core sphere, chitosan forms odd number of shells, and sodium alginate also forms even numbers of shells; the loose porous sponge structure is formed by crosslinking sodium alginate and chitosan through positive and negative ions and has good internal three-dimensional pore structure; the slow-release microspheres and the loose porous sponge structure are organically combined under the interaction of positive and negative ions without changing the their original structures. The personalized novel plastic slow-release microsphere scaffold material having different physical features and capable of supporting and slowly releasing different drugs can be prepared herein as required.

Description

technical field [0001] The invention belongs to the field of tissue engineering bone scaffold materials, and in particular relates to a novel plastic slow-release microsphere scaffold material with the function of carrying multiple drugs, which uses sodium alginate and chitosan as raw materials and a preparation method thereof. Background technique [0002] With the improvement of people's material living standards, the diagnosis and treatment of bone defects caused by serious accident trauma, patient tumor resection, infection and other factors have become more complicated. At present, autologous bone transplantation is the most effective method clinically, but the source of autologous bone is limited, and its extraction will cause secondary harm to the patient's physiology and psychology. Therefore, the allogeneic bone has become the most important bone graft material in clinical practice due to its good osteoconductivity. Direct osteogenic activity, resulting in the decl...

AI Technical Summary

Problems solved by technology

However, in the process of bone transplantation, the newly transplanted tissue-engineered bone has poor compatibility with the host, and cannot establish a good blood supply relationship with the host in a short period of time, and there are wounds in the bone transplantation operation, and there is a possibility of infection or potential infection in the bone defect. It is difficult for biological factors and drugs to gather and play a role in the transplanted tissue-engineered bone, and the osteogenic activity potential of the tissue-engineered bone lacking biological factor regulation cannot be fully exerted, and a large number of potential bacteria can cause infection of the transplanted tissue-engineered bone, leading to graft failure

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