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A method for preparing nano drug particles with uniform and controllable size

A technology of nano-medicines and granules, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations of non-active ingredients. The effect of convenience and high drug loading capacity

Active Publication Date: 2020-07-03
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this reprecipitation technique is very simple, it faces a series of problems such as low production rate, relatively large particle size and batch-to-batch inconsistency
In fact, the low yield of this method is also a major obstacle to animal and clinical trials

Method used

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  • A method for preparing nano drug particles with uniform and controllable size
  • A method for preparing nano drug particles with uniform and controllable size
  • A method for preparing nano drug particles with uniform and controllable size

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The template method is used to prepare pure nano teniposide particles, the steps are:

[0029] (1) Prepare an alumina template with a pore size of about 60 nanometers by changing the type of electrolyte, the size of the oxidation voltage, and the time of hole expansion. Among them, the electrolyte is 0.3mol / L oxalic acid solution, the oxidation voltage is 40V, and the hole expansion time is 6min;

[0030] (2) Mix and stir teniposide, Tween surfactant, cosolvent and inorganic salt according to the mass ratio of 1:15:6:10 to prepare a drug solution, wherein the Tween surfactant is Tween-80 , the co-solvent is a mixture of N,N-dimethylacetamide and polyethylene glycol 400 in a mass ratio of 1:3; the inorganic salt is sodium bisulfate;

[0031] (3) Stir to a uniform solution, soak the alumina template in the solution for 10 minutes and then take it out;

[0032] (4) According to figure 1 As shown, the alumina template is put into the vacuum filtration device, the vacuum ...

Embodiment 2

[0039] The template method is used to prepare pure nano teniposide particles, the steps are:

[0040] (1) Prepare an alumina template with a pore size of about 20 nanometers by changing the type of electrolyte, the size of the oxidation voltage, and the time of hole expansion, wherein the electrolyte is a 0.3mol / L sulfuric acid solution, and the oxidation voltage is 25V , the reaming time is 5min;

[0041] (2) Mix and stir teniposide, Tween surfactant, cosolvent and inorganic salt according to the mass ratio of 1:15:6:10 to prepare a drug solution, wherein the Tween surfactant is Tween-80 , the co-solvent is a mixture of N,N-dimethylacetamide and polyethylene glycol 400 in a mass ratio of 1:3; the inorganic salt is sodium bisulfate;

[0042] (3) Stir to a uniform solution, soak the alumina template in the solution for 10 minutes and then take it out;

[0043] (4) According to figure 1 As shown, the alumina template is put into the vacuum filtration device, the vacuum filtra...

Embodiment 3

[0050] The template method is used to prepare pure nano teniposide particles, the steps are:

[0051] (1) Prepare an alumina template with a pore size of about 100 nanometers by changing the type of electrolyte, the size of the oxidation voltage, and the time of hole expansion, wherein the electrolyte is a 0.2mol / L sulfuric acid solution, and the oxidation voltage is 50V , the reaming time is 6min;

[0052] (2) Mix and stir teniposide, Tween surfactant, cosolvent and inorganic salt according to the mass ratio of 1:10:2:5 to prepare a drug solution, wherein the Tween surfactant is Tween-80 , the co-solvent is a mixture of N,N-dimethylacetamide and polyethylene glycol 400 in a mass ratio of 1:1; the inorganic salt is sodium bisulfate;

[0053] (3) Stir to a uniform solution, soak the alumina template in the solution for 5 minutes and then take it out;

[0054] (4) According to figure 1 As shown, the alumina template is put into the vacuum filtration device, the vacuum filtrat...

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Abstract

The invention relates to a preparation method of nanodrug particles with uniform and controllable size. The preparation method comprises the following steps of: preparing an aluminum oxide template; preparing a drug solution; soaking the aluminum oxide template in the drug solution for 5-20min and taking out the aluminum oxide template for suction filtration; after suction filtration, taking out the aluminum oxide template and drying by distillation; immersing the aluminum oxide template into a diluted sodium hydroxide solution; performing centrifugalization for 5-10 times to thoroughly clean residual sodium hydroxide; and dispersing pure nanodrug particles in deionized water by means of an ultrasonic cleaner. Preparation of the drug particles is constrained by an external condition, i.e., the aluminum oxide template, and the required nanodrug particles will be left in pores of the aluminum oxide template, so that the size of the nanodrug particles is controlled at about 20nm, and the uniform controllability of the drug particle size is realized. The preparation method has the characteristics of being simple in process, convenient to operate, high in productivity, low in cost and the like. The prepared pure nanodrug particles have very strong stability and high drug-loading ability in water, and the anti-cancer ability is also higher than nanoparticles prepared by a conventional method.

Description

technical field [0001] The invention relates to a preparation method of nano drug particles, in particular to a preparation method of uniform and controllable size nano drug particles. Background technique [0002] Due to the unique size effect of nanomaterials, nanostructured materials have many different physical, chemical and biological properties compared with traditional macroscopic materials. With the advancement and development of science and technology, the combination of nanomaterials and biomedicine is getting closer, such as oral insulin nanocapsules, which can reduce the damage of enzymes in the body to insulin and make its hypoglycemic effect last for 7 days. These nanostructure results The application of nanomaterials shows attractive application prospects in medical treatment. Especially for the treatment of cancer, it is well known that cancer is one of the most devastating diseases with more than 10 million new cases worldwide every year. Although chemothe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K31/7048A61K47/02A61K47/26A61K47/10A61K47/18A61P35/00
CPCA61K9/5115A61K9/5123A61K9/5146A61K31/7048
Inventor 王军董晓曦宁爱凤张鹏
Owner NINGBO UNIV