Coaxial electrospun injectable fibers and preparation method thereof

A coaxial electrospinning and fiber technology, which is applied in fiber processing, fiber chemical characteristics, cellulose/protein conjugated artificial filaments, etc., can solve problems such as invasive operations, achieve faster release speed, and reduce the number of administrations , good mechanical properties

Active Publication Date: 2017-09-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides a coaxial electrospinning injectable fiber and its preparation method, which can position injection for drug delivery and control the drug release stage, which effectively solves the invasiveness of the existing drug delivery technology. operational problems

Method used

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  • Coaxial electrospun injectable fibers and preparation method thereof
  • Coaxial electrospun injectable fibers and preparation method thereof
  • Coaxial electrospun injectable fibers and preparation method thereof

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Embodiment 1

[0037] A preparation method for coaxial electrospinning injectable fibers, comprising the following steps:

[0038] (1) dissolving chitosan in a mixed solution with a volume ratio of trifluoroacetic acid and dimethyl carbonate of 8:2, adjusting the pH value of the mixed solution with 1% acetic acid to 5, stirring evenly, then adding Kang Pretin, stirred evenly, to obtain the shell solution; wherein, the weight-to-volume ratio of chitosan and the mixed solution is 0.1:2, and the weight-to-volume ratio of compretin and the mixed solution is 0.1:5;

[0039] (2) Dissolve polylactic acid-glycolic acid copolymer in a mixed solution of dichloromethane and N,N-dimethylamide with a volume ratio of 7:3, stir evenly, add hydroxycamptothecin, continue stirring, and then add Sodium chloride particles with a particle size of 250nm are uniformly mixed to obtain a core layer solution; wherein, the weight-to-volume ratio of the mixed solution of polylactic acid-glycolic acid copolymer to dichl...

Embodiment 2

[0049] A preparation method for coaxial electrospinning injectable fibers, comprising the following steps:

[0050] (1) Dissolving chitosan in a mixed solution with a volume ratio of 7:3 between trifluoroacetic acid and dimethyl carbonate, adjusting the pH value of the mixed solution to 4.5 with 3% acetic acid, stirring evenly, then adding Kang Pretin, stirred evenly, to obtain the shell solution; wherein, the weight-to-volume ratio of chitosan and the mixed solution is 0.3:2, and the weight-to-volume ratio of compretin and the mixed solution is 0.4:5;

[0051] (2) Dissolve polylactic acid-glycolic acid copolymer in a mixed solution with a volume ratio of methylene chloride and N,N-dimethylamide of 8:2, stir evenly, add hydroxycamptothecin, continue stirring, and then add Sodium chloride particles with a particle size of 248nm are uniformly mixed to obtain a core layer solution; wherein, the weight-to-volume ratio of the mixed solution of polylactic acid-glycolic acid copolyme...

Embodiment 3

[0061] A preparation method for coaxial electrospinning injectable fibers, comprising the following steps:

[0062] (1) Chitosan is dissolved in trifluoroacetic acid and dimethyl carbonate volume ratio in the mixed solution that is 7.5:2.5, is that the pH value of 2% acetic acid adjustment mixed solution is 3 with concentration, stirs, then adds Kang Pretin, stirred uniformly to obtain a shell solution; wherein, the weight-to-volume ratio of chitosan and the mixed solution is 0.2:2, and the weight-to-volume ratio of compretin to the mixed solution is 0.35:5;

[0063] (2) Dissolve polylactic acid-glycolic acid copolymer in a mixed solution of dichloromethane and N,N-dimethylamide with a volume ratio of 9:1, stir evenly, add hydroxycamptothecin, continue stirring, and then add Sodium chloride particles with a particle size of 250nm are uniformly mixed to obtain a core layer solution; wherein, the weight-to-volume ratio of the mixed solution of polylactic acid-glycolic acid copol...

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Abstract

The invention discloses coaxial electrospun injectable fibers and a preparation method thereof. Each fiber comprises a core-layer fiber and a shell-layer fiber covering the core-layer fiber; the preparation method of the injectable fibers comprises the following steps: (1) preparing a shell layer solution; (2) preparing a core layer solution; (3) preparing by adopting a coaxial electrospinning technology to obtain coaxial electrospun fiber membranes; putting the fiber membranes into ultrapure water at 0 to 4 DEG C, and standing for 2min to 5min; then putting the fiber membranes into an ice bath and carrying out ultrasonic oscillation for 20 to 36 times and for 4min to 6min; then centrifuging at the speed of 1200r / min to 2000r / min for 5min to 8min; collecting sediment and drying in vacuum to obtain the coaxial electrospun injectable fibers. According to the coaxial electrospun injectable fibers prepared by the preparation method, the injectable characteristic is added on the basis of a time sustained-release property, intramuscular administration can be positioned, and a medicine sustained-release phase and the like are controlled, so that the effect of minimally invasive treatment is realized, the treatment difficulty and risks are reduced, the invasive operation is reduced, and treatment pains are prevented.

Description

technical field [0001] The invention belongs to the field of slow-release biological materials, and in particular relates to a coaxial electrospinning injectable fiber and a preparation method thereof. Background technique [0002] At present, many chemical drugs often use systemic drug administration in clinical practice. Due to the limitation of half-life, the blood drug concentration is not easy to maintain, and the drug dose reaching the pharmacological action area is limited, it is difficult to maintain an effective therapeutic concentration, and the dosage or frequency of administration is increased. After that, it is easy to produce relatively large side effects or toxic reactions to tissues and organs, or to cause obvious damage to the organs of the metabolic pathway during drug metabolism; even if local administration is adopted, due to the small molecular weight of the drug, it is not easy to stay in the tumor tissue and spread easily to surrounding tissues. On th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/42A61K47/36A61K47/10A61K47/34A61K31/09A61K31/4745A61P35/00D01F8/02D01F8/18D01F8/16D01F8/14D01F8/10D01D5/00D01D5/34
CPCA61K9/0002A61K9/0024A61K9/0092A61K31/09A61K31/4745A61K47/10A61K47/34A61K47/36A61K47/42D01D5/0015D01D5/34D01F8/02D01F8/10D01F8/14D01F8/16D01F8/18A61K2300/00
Inventor 罗恩刘瑶刘显毕瑞野林云锋周腾飞
Owner SICHUAN UNIV
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