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Bacterial cellulose patch for gynecology department and preparation method

A technology of bacterial cellulose and cellulose, applied in medical science, prosthesis, surgery, etc., can solve problems that cannot be used to treat gynecological diseases

Active Publication Date: 2017-09-01
北京融知生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Bacterial cellulose, as a natural biological material, is being increasingly used to treat diseases, but the bacterial cellulose supplement disclosed in Chinese patent ZL 201410089918.8 "a bacterial cellulose biopatch and its manufacturing method" Due to the limitations of the material structure, the tablet is still only used to treat diseases such as inguinal hernia, but not to treat gynecological diseases.

Method used

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  • Bacterial cellulose patch for gynecology department and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prepare as follows:

[0022] Step 1: 100g freeze-dried bacterial cellulose slurry was stirred and dispersed in 400ml phosphate buffer solution (0.05M, pH value was about 6.89), and then 0.06g TEMPO, 3gNaClO 2 Pour into the above system respectively, and stir to mix; the stirring speed is 10000rmp. The cellulose used is produced from the metabolites of Acetobacter xylinum in the genus Acetobacter, and its chemical composition is glucopyranose monomer (β-D-glucose) linked by β-1,4-glycosidic bonds. A kind of unbranched, macromolecular branched chain polymer is formed, which is composed of unique filamentous fibers, the fiber diameter is between 3 and 4nm, and the width of each filamentary fiber can reach 30 to 100nm, and the purity can reach 99%. , does not contain hemicellulose, lignin, pectin and other cell wall components.

[0023] The 2nd step: get 2mlNaClO solution, be dissolved in 100ml phosphate buffered solution (0.05M, pH value is about 6.89), then pour into th...

Embodiment 2

[0028] The preparation method with embodiment 1 is basically the same, but adopts following different condition parameters:

[0029] 1. Dilute the NaClO in step 1 2 Change to KClO 2 , and the amount of bacterial cellulose slurry is 110g, the amount of 2,2,4,4-tetramethylpiperidine nitrogen oxide stable free radical is 0.08g and KClO 2 The dosage is 4g.

[0030] 2. Replace NaClO in step 2 with KClO.

[0031] 3. Replace NaOH in step 3 with KOH, and the mass ratio of the three compounds in the system composed of KOH, urea and water is 4:7:45.

[0032] The prepared cellulose patch is porous, the aperture is 1.8mm, and the thickness is 0.06mm. After testing, the density of the dry film when the patch does not absorb water is 1.15g / cm 3 1.08~2.35g / cm 3 . When the water content of the patch is 50%, the breaking strength can reach 65MPa.

Embodiment 3

[0034] The preparation method with embodiment 1 is basically the same, but adopts following different condition parameters:

[0035] 1. Replace the crosslinking agent epichlorohydrin used in the 3rd step with maleic acid polyacid.

[0036] 2. The temperature in the cycle freezing step in the fourth step is -50°C for 30 hours; stand at 25°C for 30 minutes and cycle 5 times; then freeze at -30°C for 48 hours.

[0037] The prepared cellulose patch is porous, with a pore diameter of 1 mm and a thickness of 0.09 mm. After testing, the density of the dry film when the patch does not absorb water is 2.35 g / cm -3 . When the water content of the patch is 50%, the breaking strength can reach 70Mpa.

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Abstract

The invention provides a bacterial cellulose patch for the gynecology department. Cellulose is prepared from silky fiber, and the polymerization degree is 2,000 to 20,000; the cellulose is of a porous and reticulated and has the thickness of 0.04to 0.09 mm. The bacterial cellulose patch is obtained by a freeze-thaw cycle method. Due to the reticulated structure, a biological path material of the bacterial cellulose patch can be used for treating ventral hernia; furthermore, the most important significance is to treat gynaecopathia; the defect of serial complications easily caused by lumps of surrounding tissues due to low biocompatibility, hardness, coarseness and long-term foreign matter stimulation of a polypropylene material adopted in the existing gynecology department can be completely overcome; the infection risk when the patch material is applied to gynaecopathia treatment is greatly reduced, and the application range of the cellulose patch is greatly expanded.

Description

technical field [0001] The invention relates to a cellulose patch and a preparation method, in particular to a bacterial cellulose patch which can be used in gynecology and a preparation method. Background technique [0002] The patch materials currently used in the treatment of female pelvic floor dysfunction (PFD) are basically polypropylene-based materials (pure polypropylene or polypropylene composite materials). This kind of material has poor biocompatibility, hard and rough texture, and long-term foreign body stimulation can easily cause hard lumps in the surrounding tissues, affecting physiological functions, such as vaginal tissue hardening, bladder perforation, abrasion and erosion of local tissues, causing a series of complications, becoming a potential Source of infection. In July 2011, the US Food and Drug Administration (FDA) targeted its use in pelvic floor organ prolapse and urinary incontinence surgery. Bacterial cellulose, as a natural biological material,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/56A61L27/50
CPCA61L27/20A61L27/50A61L27/56A61L31/042A61L31/14A61L31/146C08L1/02
Inventor 石毅峰崔志明
Owner 北京融知生物科技有限公司
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