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A preparation method of proanthocyanidin molecularly imprinted adsorption material on the surface of loofah

A procyanidin and molecular imprinting technology, applied in separation methods, chemical instruments and methods, solid adsorbent liquid separation, etc., can solve the problems of reducing the utilization rate of imprinting sites, uneven distribution of imprinting sites, and mechanical properties of template leakage. , to achieve the effects of excellent mechanical stability, short elution time and good physical and chemical stability

Inactive Publication Date: 2019-02-22
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The device required by this method is simple and universal, but there are usually the following problems: (1) The controllability is poor during the grinding process, and some irregular particles are inevitably generated, and some imprinted spots are destroyed at the same time
The qualified particles obtained after sieving are generally less than 50%, resulting in obvious waste; (2) there are too deep embedding of template molecules, difficulty in elution, template leakage and low mechanical properties; (3) uneven distribution of imprinted sites , some of them are located above the particle pores, and their mass transfer rate is faster, while others are embedded in the polymer body, which is affected by steric hindrance, has poor accessibility, and the rate of recombining template molecules is slow, thereby reducing the number of imprinted sites. Utilization of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Preparation of surface modified loofah: In the reactor, add ethanol: 84 mL, γ-glycidyl etheroxypropyl trimethoxysilane: 24g, oxidized loofah: 10g, and keep the temperature at 55±2℃ , stirring, and reflux reaction for 4 h. After the reaction, wash with ethanol, take it out, and dry it in a vacuum oven to obtain surface-modified loofah;

[0021] (2) Preparation of proanthocyanidin molecularly imprinted adsorption material on the surface of loofah: In the reactor, add ethanol: 73 mL, ethylene glycol dimethacrylate: 12 g, N-vinylpyrrolidone: 8 g, proanthocyanidin: 6 g, on the surface Modified loofah: 14g, azobisisobutyronitrile: 2.0g, stirring and dissolving, passing an inert gas to remove oxygen for 10min, in an oxygen-free atmosphere, stirring and reacting at 60±2°C for 9h, and the obtained product was mixed with methanol:acetic acid volume ratio of Soak in the 8:1 mixed solution for 20 hours, remove the template molecules, and dry to obtain the proanthocyanidin molec...

Embodiment 2

[0023] (1) Preparation of surface modified loofah: In the reactor, add ethanol: 87 mL, γ-glycidyl etheroxypropyl trimethoxysilane: 22g, oxidized loofah: 8g, keep the temperature at 55±2℃ , stirring, and reflux reaction for 4 h. After the reaction, wash with ethanol, take it out, and dry it in a vacuum oven to obtain surface-modified loofah;

[0024] (2) Preparation of proanthocyanidin molecularly imprinted adsorption material on the surface of loofah: In the reactor, add ethanol: 66 mL, ethylene glycol dimethacrylate: 15 g, N-vinylpyrrolidone: 10 g, proanthocyanidin: 7 g, on the surface Modified loofah: 1g, azobisisobutyronitrile: 2.0g, stirring and dissolving, passing an inert gas to remove oxygen for 10min, in an oxygen-free atmosphere, stirring and reacting at 60±2°C for 8h, and the obtained product was mixed with methanol: acetic acid volume ratio of Soak in the 8:1 mixed solution for 20 hours, remove the template molecules, and dry to obtain the proanthocyanidin molecular...

Embodiment 3

[0026] (1) Preparation of surface-modified loofah: In the reactor, add ethanol: 81 mL, γ-glycidyl etheroxypropyl trimethoxysilane: 25g, oxidized loofah: 11g, and keep the temperature at 55±2℃ , stirring, and reflux reaction for 4 h. After the reaction, wash with ethanol, take it out, and dry it in a vacuum oven to obtain surface-modified loofah;

[0027](2) Preparation of proanthocyanidin molecularly imprinted adsorption material on the surface of loofah: In the reactor, add ethanol: 78 mL, ethylene glycol dimethacrylate: 10 g, N-vinylpyrrolidone: 6 g, proanthocyanidin: 8 g, on the surface Modified loofah: 11g, azobisisobutyronitrile: 3.0g, stirring and dissolving, passing an inert gas to remove oxygen for 10min, in an oxygen-free atmosphere, stirring and reacting at 60±2°C for 10h, and the obtained product was mixed with methanol: acetic acid volume ratio of Soak in the 8:1 mixed solution for 20 hours, remove the template molecules, and dry to obtain the proanthocyanidin mole...

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Abstract

The invention discloses a preparation method of a retinervus luffae fructus surface procyanidin molecular imprinting adsorption material. The preparation method comprises: carrying out surface modification on retinervus luffae fructus by using gamma-glycidoxypropyltrimethoxysilane to obtain surface modified retinervus luffae fructus; respectively adding 52-62% of ethanol, 10-15% of ethylene dimethacrylate, 6-10% of N-vinylpyrrolidone, 4.0-8.0% of procyanidin, 10-15% of the surface modified retinervus luffae fructus, and 1.0-3.0% of azobisisobutyronitrile to a reactor; and carrying out stirring dissolving, carrying out a stirring reaction for h in the absence of oxygen, and removing the template molecule from the obtained product by using a methanol and acetic acid mixed solution so as to obtain the retinervus luffae fructus surface procyanidin molecular imprinting adsorption material. According to the present invention, the retinervus luffae fructus surface procyanidin molecular imprinting adsorption material can specifically recognize procyanidin, and further has advantages of high selectivity, good chemical stability, fast adsorption, easy elution, biodegradability, simple process, regenerative ability, environmental protection, and the like.

Description

technical field [0001] The invention relates to a preparation method and application technology of a molecularly imprinted adsorption material, in particular to a preparation method of a proanthocyanidin molecularly imprinted adsorption material on the surface of loofah, and belongs to the technical field of separation material application. Background technique [0002] Proanthocyanidins, referred to as OPC, its molecular formula is C 30 h 12 o 6 , with a relative molecular mass of 468.24, is a bioflavonoid with a special molecular structure, and is currently internationally recognized as the most effective natural antioxidant for eliminating free radicals in the human body. It is generally a reddish-brown powder with a slight gas and astringent taste, soluble in water and most organic solvents. The latest research shows that blueberry leaf extract proanthocyanidins can prevent the replication of hepatitis C virus. It is a bioflavonoid with a special molecular structure,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/30B01D15/38
CPCB01D15/3852B01J20/24B01J20/268B01J2220/485
Inventor 李慧芝李晓峰杨秋苹
Owner UNIV OF JINAN
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