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Traditional Chinese medicine composition for preventing and treating porcine eperythrozoonosis and preparation method and application thereof

A porcine Eperythrocytes and composition technology, which is applied in antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as environmental pollution, pork poisonous arsenic residues, and harm to consumers' health, so as to avoid drugs Residual, good therapeutic effect

Active Publication Date: 2017-09-15
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some even use arsenic preparations for treatment. Although it has a certain effect, it pollutes the environment, and the toxic arsenic residue in pork endangers the health of consumers.

Method used

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  • Traditional Chinese medicine composition for preventing and treating porcine eperythrozoonosis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Treatment of mice artificially infected with Eperythrozoon:

[0011] 1 Test materials and methods:

[0012] 1.1 Test material:

[0013] 1.1.1 Experimental animals: Kunming mice, whose blood was collected through the tail vein to make fresh blood pressure films for microscopic examination, confirmed no Eperythrozoon infection, weighing 18-22 g, half female and half male, purchased from Lanzhou University School of Medicine.

[0014] 1.1.2 Test equipment and reagents:

[0015] Optical microscope (XSP-C104B), micropipette, sterile syringe, syringe, etc., PBS, saline. Test drug: 6 parts by weight of croton, 4 parts by weight of licorice, crushed, mixed evenly, and obtained. Control drug: Triazamidine, produced by Lanzhou Zhengfeng Pharmaceutical Co., Ltd., batch number: 160412.

[0016] 1.2 Test method:

[0017] For artificial infection, the pig blood sample infected with Eperythrozoon was washed three times with PBS, and diluted with an equal volume of sterilized sali...

Embodiment 2

[0027] clinical experiments:

[0028] 1 Materials and methods:

[0029] 1.1 Test material:

[0030] Selected 163 diseased pigs naturally infected with Eperythrozoon (suburban farm of Dingxi City, Gansu Province) as experimental animals. The diseased pigs mainly showed loss of appetite, lethargy, body temperature rising as high as 40-41°C, constipation first, then diarrhea, and loss of appetite. , Difficulty breathing, conjunctiva first flushed, then pale, yellow stained, ears, limbs, abdomen and other skin with reddish-purple spots. Microscopic examination was carried out on the blood of the above diseased pigs, and Eperythrozoon positive infected pigs were selected as experimental animals.

[0031] 1.2 Test method: The test was divided into 2 groups, namely the triazine group with 80 animals and the drug group of the present invention with 83 animals.

[0032] Triazamidine group: intramuscular injection, 6mg / kg (body weight) / d, dissolved in normal saline, for 3 consecutive...

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating porcine eperythrozoonosis, the traditional Chinese medicine composition being prepared from, by weight, 3 parts of croton seed and 2 parts of licorice root, and also provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition and the preparation method and application thereof have the advantages that Chinese herbs are used as raw materials and are scientifically matched to obtain the traditional Chinese medicine composition, the traditional Chinese medicine composition is effective in clearing heat and drying damp, killing parasites and eliminating stagnation, can effectively kill Eperythrozoon, and has good treatment effect with cure rate up to 60% and above, the use of chemical agents and arsenic preparations in the treatment of porcine eperythrozoonosis is avoided, and the chemicals residue problem in animal-derived foods is avoided.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparation, in particular to a traditional Chinese medicine composition for preventing and treating porcine eperythrozoonosis, a preparation method and application thereof. Background technique [0002] Eperythrozoonosis is a zoonotic infectious disease caused by Eperythrozoon infection. Eperythrozoon is a kind of microorganism that parasitizes on the surface of red blood cells, plasma and bone marrow. Pigs are usually more prone to Eperythrozoonosis, which is an acute, febrile infectious disease caused by Eperythrozoon attached to the surface of pig red blood cells or dissociated in the plasma, which occurs in many countries and regions and popular. Clinically, the disease is characterized by fever, anemia, hemolytic jaundice, dyspnea, redness of the skin, etc., resulting in immunosuppression of the animal body, reproductive impairment, and low birth survival rate. In recent years, it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K9/14A61P31/04
CPCA61K9/14A61K36/47A61K36/484A61K2300/00
Inventor 苗小楼尚小飞李芸潘虎王瑜王东升李冰
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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