Medicine for treating chronic gastritis and hyperacidity and preparation method thereof

A technology for hyperacidity and chronic gastritis, applied in the field of pharmaceuticals, can solve the problems of slow patient symptoms, disintegration and slow onset, and low bioavailability, so as to improve bioavailability and reduce adverse effects. Response, high bioavailability effect

Inactive Publication Date: 2017-10-10
广西大海阳光药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problems of poor water solubility, slow disintegration and onset of effect, low dissolution rate, low bioavailability, and inability to quickly exert the drug effect in the existing sucralfate tablets so as to quickly alleviate the symptoms of chronic patients, etc., and provides

Method used

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  • Medicine for treating chronic gastritis and hyperacidity and preparation method thereof
  • Medicine for treating chronic gastritis and hyperacidity and preparation method thereof
  • Medicine for treating chronic gastritis and hyperacidity and preparation method thereof

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0063] Example 1

[0064] A preparation method for preparing a dispersible tablet from a medicine for treating chronic gastritis and hyperacidity includes the following steps:

[0065] T1: Weigh the following components by weight: 2000g sucralfate, 400g crospovidone, 200g hydroxypropyl methylcellulose, 1200g dextran, 200g sodium carboxymethyl starch, sodium lauryl sulfate 200g, 100g micronized silica gel, 100g magnesium stearate, pass through a 100-mesh sieve, set aside;

[0066] T2: Preparation of Sucralfate Solid Dispersion: Take crospovidone and put it in the batching pot, add an appropriate amount of absolute ethanol and heat at 35℃ to dissolve it, keep the temperature at 35℃, add sucralfate, keep warm and stir for 5 hours , Placed at room temperature, dried at 50°C for 10h under -0.06Mpa vacuum, taken out, crushed, and passed through an 80-mesh sieve to obtain a sucralfate solid dispersion, and its moisture content is determined to be 5.8%;

[0067] T3: Dissolve hydroxypropyl me...

Example Embodiment

[0072] Example 2

[0073] A preparation method for preparing a dispersible tablet from a medicine for treating chronic gastritis and hyperacidity includes the following steps:

[0074] T1: Weigh the following components by weight: 2000g sucralfate, 800g crospovidone, 400g hydroxypropyl methylcellulose, 1600g dextran, 400g sodium carboxymethyl starch, sodium lauryl sulfate 400g, 140g micronized silica gel, 140g magnesium stearate, pass through a 100-mesh sieve, set aside;

[0075] T2: Preparation of Sucralfate Solid Dispersion: Take cross-linked povidone and put it in the batching pot, add an appropriate amount of absolute ethanol and heat at 45℃ to dissolve it, keep the temperature at 45℃, add sucralfate, keep warm and stir for 4 hours , Placed at room temperature, dried at 65°C for 8h under -0.08Mpa vacuum, taken out, crushed, and passed through an 80-mesh sieve to obtain a sucralfate solid dispersion, and its moisture content is determined to be 4.5%;

[0076] T3: Dissolve hydroxyp...

Example Embodiment

[0081] Example 3

[0082] A preparation method for preparing a dispersible tablet from a medicine for treating chronic gastritis and hyperacidity includes the following steps:

[0083] T1: Weigh the following components by weight: sucralfate 2000g, crospovidone 600g, hydroxypropyl methylcellulose 300g, dextran 1400g, sodium carboxymethyl starch 300g, sodium lauryl sulfate 300g, 120g micronized silica gel, 120g magnesium stearate, pass through a 100-mesh sieve, set aside;

[0084] T2: Preparation of Sucralfate Solid Dispersion: Take cross-linked povidone and put it in the batching pot, add an appropriate amount of absolute ethanol and heat at 40℃ to dissolve, keep the temperature at 40℃, add sucralfate, keep warm and stir for 4.5 hours , Placed at room temperature, dried at 60°C for 9h at -0.09Mpa vacuum, taken out, crushed, and passed through an 80-mesh sieve to obtain a sucralfate solid dispersion, and its moisture content is determined to be 3.2%;

[0085] T3: Dissolve hydroxypropy...

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Abstract

The invention discloses a medicine for treating chronic gastritis and hyperacidity and a preparation method thereof. The medicine for treating chronic gastritis and hyperacidity is prepared from the following components in parts by weight: 100 parts of sucralfate, 20-40 parts of crospovidone, 10-20 parts of hydroxypropyl methylcellulose, 60-80 parts of glucan, 10-20 parts of sodium carboxymethyl starch, 10-20 parts of sodium dodecyl sulfate, 5-7 parts of micropowder silica gel and 5-7 parts of magnesium stearate. According to the preparation method disclosed by the invention, the sucralfate and the crospovidone are dissolved together in a solvent, a solid dispersion is prepared by a drying technique under reduced pressure, and then the solid dispersion is further prepared into dispersible tablets. The sucralfate in the product disclosed by the invention has increased dissolubility, higher dissolution rate, shortened disintegration time limited and improved bioavailability, thereby improving the curative effect, and the preparation method has simple process, low production cost, low energy consumption and easy implementation of industrialized production.

Description

technical field [0001] The invention belongs to the field of medicines and relates to a medicine and a preparation method thereof, in particular to a medicine for treating chronic gastritis and hyperacidity and a preparation method thereof. Background technique [0002] Sucralfate, an anti-peptic ulcer drug, has the functions of protecting the ulcer surface and promoting ulcer healing. Modern pharmacological studies have shown that sucralfate has: (1) In an acidic environment, sucrose sulfate compound ions are dissociated, and the compound ions are polymerized into insoluble negatively charged colloids, which can interact with positively charged protein exudates on the ulcer surface Combined, it forms a protective film covering the ulcer surface to promote ulcer healing; (2) has the effect of adsorbing pepsin and bile acid; (3) can promote the synthesis of endogenous prostaglandins and adsorb epidermal growth factor (EGF), Make it concentrated in the ulcer to facilitate the...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/36A61K47/20A61K47/38A61K47/02A61K47/04A61K31/7024A61P1/04
CPCA61K9/2059A61K9/2009A61K9/2013A61K9/205A61K9/2054A61K9/2095A61K31/7024
Inventor 黄大权唐新
Owner 广西大海阳光药业有限公司
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