Medicine for treating chronic gastritis and hyperacidity and preparation method thereof
A technology for hyperacidity and chronic gastritis, applied in the field of pharmaceuticals, can solve the problems of slow patient symptoms, disintegration and slow onset, and low bioavailability, so as to improve bioavailability and reduce adverse effects. Response, high bioavailability effect
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[0063] Example 1
[0064] A preparation method for preparing a dispersible tablet from a medicine for treating chronic gastritis and hyperacidity includes the following steps:
[0065] T1: Weigh the following components by weight: 2000g sucralfate, 400g crospovidone, 200g hydroxypropyl methylcellulose, 1200g dextran, 200g sodium carboxymethyl starch, sodium lauryl sulfate 200g, 100g micronized silica gel, 100g magnesium stearate, pass through a 100-mesh sieve, set aside;
[0066] T2: Preparation of Sucralfate Solid Dispersion: Take crospovidone and put it in the batching pot, add an appropriate amount of absolute ethanol and heat at 35℃ to dissolve it, keep the temperature at 35℃, add sucralfate, keep warm and stir for 5 hours , Placed at room temperature, dried at 50°C for 10h under -0.06Mpa vacuum, taken out, crushed, and passed through an 80-mesh sieve to obtain a sucralfate solid dispersion, and its moisture content is determined to be 5.8%;
[0067] T3: Dissolve hydroxypropyl me...
Example Embodiment
[0072] Example 2
[0073] A preparation method for preparing a dispersible tablet from a medicine for treating chronic gastritis and hyperacidity includes the following steps:
[0074] T1: Weigh the following components by weight: 2000g sucralfate, 800g crospovidone, 400g hydroxypropyl methylcellulose, 1600g dextran, 400g sodium carboxymethyl starch, sodium lauryl sulfate 400g, 140g micronized silica gel, 140g magnesium stearate, pass through a 100-mesh sieve, set aside;
[0075] T2: Preparation of Sucralfate Solid Dispersion: Take cross-linked povidone and put it in the batching pot, add an appropriate amount of absolute ethanol and heat at 45℃ to dissolve it, keep the temperature at 45℃, add sucralfate, keep warm and stir for 4 hours , Placed at room temperature, dried at 65°C for 8h under -0.08Mpa vacuum, taken out, crushed, and passed through an 80-mesh sieve to obtain a sucralfate solid dispersion, and its moisture content is determined to be 4.5%;
[0076] T3: Dissolve hydroxyp...
Example Embodiment
[0081] Example 3
[0082] A preparation method for preparing a dispersible tablet from a medicine for treating chronic gastritis and hyperacidity includes the following steps:
[0083] T1: Weigh the following components by weight: sucralfate 2000g, crospovidone 600g, hydroxypropyl methylcellulose 300g, dextran 1400g, sodium carboxymethyl starch 300g, sodium lauryl sulfate 300g, 120g micronized silica gel, 120g magnesium stearate, pass through a 100-mesh sieve, set aside;
[0084] T2: Preparation of Sucralfate Solid Dispersion: Take cross-linked povidone and put it in the batching pot, add an appropriate amount of absolute ethanol and heat at 40℃ to dissolve, keep the temperature at 40℃, add sucralfate, keep warm and stir for 4.5 hours , Placed at room temperature, dried at 60°C for 9h at -0.09Mpa vacuum, taken out, crushed, and passed through an 80-mesh sieve to obtain a sucralfate solid dispersion, and its moisture content is determined to be 3.2%;
[0085] T3: Dissolve hydroxypropy...
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