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Medicine for treating chronic gastritis and hyperacidity and preparation method thereof

A technology for hyperacidity and chronic gastritis, applied in the field of pharmaceuticals, can solve the problems of slow patient symptoms, disintegration and slow onset, and low bioavailability, so as to improve bioavailability and reduce adverse effects. Response, high bioavailability effect

Inactive Publication Date: 2017-10-10
广西大海阳光药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problems of poor water solubility, slow disintegration and onset of effect, low dissolution rate, low bioavailability, and inability to quickly exert the drug effect in the existing sucralfate tablets so as to quickly alleviate the symptoms of chronic patients, etc., and provides a Fast disintegration, good dissolution, high dispersion, easy absorption, high bioavailability, fast onset, easy to take for the treatment of chronic gastritis, hyperacidity of the drug and its preparation method, solve the sucralfate currently on the market The above-mentioned problems that tablets and capsules exist

Method used

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  • Medicine for treating chronic gastritis and hyperacidity and preparation method thereof
  • Medicine for treating chronic gastritis and hyperacidity and preparation method thereof
  • Medicine for treating chronic gastritis and hyperacidity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] A kind of preparation method that the medicine for treating chronic gastritis, hyperacidity is prepared into dispersible tablet, comprises the steps:

[0065] T1: Weigh the following components by weight: 2000g sucralfate, 400g crospovidone, 200g hydroxypropyl methylcellulose, 1200g dextran, 200g sodium carboxymethyl starch, sodium lauryl sulfate 200g, micropowder silica gel 100g, magnesium stearate 100g, pass through a 100-mesh sieve, set aside;

[0066] T2: Preparation of sucralfate solid dispersion: take crospovidone and put it in the batching pot, add appropriate amount of absolute ethanol and heat at 35°C to dissolve, keep the temperature at 35°C and add sucralfate, keep stirring for 5 hours , placed at room temperature, dried at 50°C for 10 h under a vacuum of -0.06Mpa, taken out, pulverized, and passed through an 80-mesh sieve to obtain a sucralfate solid dispersion, whose moisture content was determined to be 5.8%;

[0067] T3: Dissolve hydroxypropyl methylcell...

Embodiment 2

[0073] A kind of preparation method that the medicine for treating chronic gastritis, hyperacidity is prepared into dispersible tablet, comprises the steps:

[0074] T1: Weigh the following components by weight: 2000g sucralfate, 800g crospovidone, 400g hydroxypropyl methylcellulose, 1600g dextran, 400g sodium carboxymethyl starch, sodium lauryl sulfate 400g, micropowder silica gel 140g, magnesium stearate 140g, pass through a 100-mesh sieve, set aside;

[0075] T2: Preparation of sucralfate solid dispersion: take crospovidone and put it in the batching pot, add appropriate amount of absolute ethanol and heat at 45°C to dissolve, keep the temperature at 45°C and add sucralfate, keep stirring for 4 hours , placed at room temperature, dried at 65°C for 8 hours under a vacuum of -0.08Mpa, taken out, pulverized, and passed through an 80-mesh sieve to obtain a sucralfate solid dispersion, and its moisture content was determined to be 4.5%;

[0076] T3: take hydroxypropyl methylcel...

Embodiment 3

[0082] A kind of preparation method that the medicine for treating chronic gastritis, hyperacidity is prepared into dispersible tablet, comprises the steps:

[0083] T1: Weigh the following components by weight: 2000g sucralfate, 600g crospovidone, 300g hydroxypropyl methylcellulose, 1400g dextran, 300g sodium carboxymethyl starch, sodium lauryl sulfate 300g, 120g of micropowder silica gel, 120g of magnesium stearate, pass through a 100-mesh sieve, and set aside;

[0084] T2: Preparation of sucralfate solid dispersion: take crospovidone and put it in the batching pot, add appropriate amount of absolute ethanol and heat at 40°C to dissolve, keep the temperature at 40°C and add sucralfate, keep stirring for 4.5 hours , placed at room temperature, dried at 60°C for 9 hours under a vacuum of -0.09Mpa, taken out, pulverized, and passed through an 80-mesh sieve to obtain a sucralfate solid dispersion, whose moisture content was determined to be 3.2%;

[0085] T3: take hydroxypropyl...

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Abstract

The invention discloses a medicine for treating chronic gastritis and hyperacidity and a preparation method thereof. The medicine for treating chronic gastritis and hyperacidity is prepared from the following components in parts by weight: 100 parts of sucralfate, 20-40 parts of crospovidone, 10-20 parts of hydroxypropyl methylcellulose, 60-80 parts of glucan, 10-20 parts of sodium carboxymethyl starch, 10-20 parts of sodium dodecyl sulfate, 5-7 parts of micropowder silica gel and 5-7 parts of magnesium stearate. According to the preparation method disclosed by the invention, the sucralfate and the crospovidone are dissolved together in a solvent, a solid dispersion is prepared by a drying technique under reduced pressure, and then the solid dispersion is further prepared into dispersible tablets. The sucralfate in the product disclosed by the invention has increased dissolubility, higher dissolution rate, shortened disintegration time limited and improved bioavailability, thereby improving the curative effect, and the preparation method has simple process, low production cost, low energy consumption and easy implementation of industrialized production.

Description

technical field [0001] The invention belongs to the field of medicines and relates to a medicine and a preparation method thereof, in particular to a medicine for treating chronic gastritis and hyperacidity and a preparation method thereof. Background technique [0002] Sucralfate, an anti-peptic ulcer drug, has the functions of protecting the ulcer surface and promoting ulcer healing. Modern pharmacological studies have shown that sucralfate has: (1) In an acidic environment, sucrose sulfate compound ions are dissociated, and the compound ions are polymerized into insoluble negatively charged colloids, which can interact with positively charged protein exudates on the ulcer surface Combined, it forms a protective film covering the ulcer surface to promote ulcer healing; (2) has the effect of adsorbing pepsin and bile acid; (3) can promote the synthesis of endogenous prostaglandins and adsorb epidermal growth factor (EGF), Make it concentrated in the ulcer to facilitate the...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/36A61K47/20A61K47/38A61K47/02A61K47/04A61K31/7024A61P1/04
CPCA61K9/2059A61K9/2009A61K9/2013A61K9/205A61K9/2054A61K9/2095A61K31/7024
Inventor 黄大权唐新
Owner 广西大海阳光药业有限公司
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