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Traditional Chinese medicine pellet and preparation method thereof

A technology of traditional Chinese medicine and micropills, which is applied in the field of traditional Chinese medicine micropills and its preparation. It can solve the problems of easy moisture absorption, caking and mildew, affecting product quality, and poor capsule shell stability. It achieves excellent drug release performance, obvious moisture-proof effect, The effect of high roundness

Active Publication Date: 2017-10-24
SICHUAN JISHENGTANG PHARMLS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The extract powder of traditional Chinese medicine raw materials or add a small amount of auxiliary materials to directly fill the capsules. Due to the strong hygroscopicity of the raw material extract powder of traditional Chinese medicine, it is easy to absorb moisture, agglomerate and mildew, etc., which will cause poor stability of the capsule shell, and the capsule shell will become brittle and rupture after long-term storage. , will cause difficulties in product transportation and seriously affect product quality

Method used

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  • Traditional Chinese medicine pellet and preparation method thereof
  • Traditional Chinese medicine pellet and preparation method thereof
  • Traditional Chinese medicine pellet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of Chinese medicine composition can prepare Chinese medicine composition by weight percentage in table 1:

[0040] The preparation of table 1 Chinese medicine composition

[0041]

[0042] Preparation:

[0043] (1) Astragalus membranaceus is removed from impurities, separated by size, washed, moistened thoroughly, cut into 2-4mm thick slices, and dried at 60-80°C for later use;

[0044] (2) Ligustrum lucidum, remove impurities and stem leaves, wash, dry at 60-80°C, and mash when used;

[0045] (3) Lycium barbarum is removed from impurities, and the fruit stems are removed, and cleaned for later use;

[0046] (4) Leeches, washed, cut into sections, and dried at 60-70°C for later use;

[0047] (5) Rhubarb, remove impurities, wash, moisten thoroughly, cut into straight slices with a thickness of 2-4mm, dry at 60-80°C, sieve to remove debris, crush, pass through a 100-mesh sieve, and take fine powder for radiation sterilization , 2KGY / hour, standby af...

Embodiment 2

[0051] The effect of diluent on the performance of pellets

[0052] The traditional Chinese medicine composition used in the following table: by containing 20% ​​by weight of Astragalus extract powder, 30% by weight of Pseudostellaria extract powder, 20% by weight of Ligustrum lucidum extract powder, 15% by weight of The leech extract powder is composed of 10% by weight wolfberry fruit extract powder and 5% by weight rhubarb medicinal material fine powder.

[0053] Preparation of pellets: According to the prescription in Table 2, pellets are prepared by extrusion spheronization method. The uniformly mixed materials are extruded and granulated through an extruder at 10-45rpm. The frequency is 10-30Hz, the speed of the peristaltic pump is 1-9rpm, until the particles are rolled into balls, the material is collected, and dried at 35-80°C.

[0054] Pellet coating: Take an appropriate amount of prepared Chinese medicine pellets and add them to the bottom spray granulation chamber o...

Embodiment 3

[0059] Effect of different excipients and their dosage on the performance of pellets

[0060] The traditional Chinese medicine composition used in Table 3 and Table 4: by weight percentage 36.14% astragalus extract powder, 12.05% weight percentage Pseudostellariae extract powder, 18.07% weight percentage Ligustrum lucidum extract powder, weight percentage It is composed of 12.05% of leech extract powder, 14.46% of wolfberry extract powder and 7.23% of fine rhubarb powder.

[0061] Preparation of pellets: According to the prescriptions in Table 3 and Table 4, pellets were prepared by extrusion spheronization method. The uniformly mixed materials were extruded and granulated through an extruder at 10-45rpm. , the blast frequency is 10-30Hz, the peristaltic pump speed is 1-9rpm, until the particles are rolled into balls, the material is collected, and dried at 35-80°C.

[0062] Pellet coating: Take an appropriate amount of prepared Chinese medicine pellets and add them to the bo...

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Abstract

The invention provides a traditional Chinese medicine pellet and a preparation method thereof, and particularly relates to a traditional Chinese medicine pellet preparation and a preparation method of the traditional Chinese medicine pellet preparation. The traditional Chinese medicine pellet preparation is prepared by six traditional Chinese medicines including radix astragali, fructus ligustri lucidi, hirudo, radix et rhizoma rhei, radix pseudostellariae and fructus lycii and other medical auxiliary materials. The traditional Chinese medicine pellet preparation contains a traditional Chinese medicine composition, a diluent and a disintegrant according to a specific ratio. The prepared pellet is obvious in moistureproof effect, high in pellet roundness and bioavailability, uniform in particle size distribution, relatively high in yield and excellent in drug release performance, and provides better selection for clinical medication.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine pellet and a preparation method thereof. Background technique [0002] The theory of traditional Chinese medicine proves that deficiency of both qi and yin is the basic symptom type of diabetes, and deficiency of yin is the internal factor leading to the onset of diabetes, and blood stasis is the pathological basis of diabetic microangiopathy. Diabetic nephropathy is developed on the basis of diabetes, and the condition is often protracted and difficult to heal. "Diseases of the five internal organs must affect the kidneys if they are poor, and the liver and kidneys have the same source" resulting in insufficient liver and kidneys. Therefore, deficiency of both qi and yin, insufficiency of liver and kidney, and blood stasis are the pathogenesis of diabetic nephropathy. Kidney deficiency can not fix the intake, water and grain essence b...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/16A61P3/10A61P13/12A61P9/10A61K35/62
CPCA61K9/1635A61K9/1652A61K35/62A61K36/36A61K36/481A61K36/638A61K36/708A61K36/815A61K2300/00
Inventor 柯潇边俊杰
Owner SICHUAN JISHENGTANG PHARMLS
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