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Sn-113/In-113m generator and preparation method

An in-113m, sn-113 technology, applied in the field of Sn-113/In-113m generator preparation, can solve the problems of large radiation dose, long operation time and low adsorption capacity of operators, and reduce the exposure Irradiation risk, effect of fast leaching rate and low leakage rate

Inactive Publication Date: 2017-10-24
天津汇康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method solves the problem of low adsorption capacity of the separating agent to tin in the disclosed separation method, but in the preparation process, complicated processes such as suction filtration, high-temperature drying, and mechanical grinding are required, and the operation is difficult, and the operation time is long and difficult to operate. Personnel are exposed to large doses of radiation

Method used

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  • Sn-113/In-113m generator and preparation method
  • Sn-113/In-113m generator and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A kind of preparation method of Sn-113 / In-113m generator, comprises the steps:

[0025] 1) In the container, put into pH=1, volume is 0.5mL tin chloride that radioactive concentration is 2GBq / mL[ 113 Sn] aqueous solution, add 5mL, 3M hydrochloric acid aqueous solution, add 2mL liquid bromine aqueous solution with a mass concentration of 99%, and then use 5M hydrochloric acid aqueous solution to adjust the radioactivity concentration to 185MBq / mL;

[0026] 2) A support frame 9 is set in the lead protection tank 7, and the support frame is connected with the heating sheet 4; the heating sheet 4 is connected with the power plug 5;

[0027] 3) Get a glass separation column with a diameter of 9 mm and a length of 100 mm, set a sieve plate 1 at the bottom of the glass separation column, put 1 mm thick glass wool on the sieve plate 1, and then put 5 g of nano-sized zirconia particles 8 into the nano-oxidized The particle diameter of the zirconium particle is 10nm, vibrating w...

Embodiment 2

[0031] A kind of preparation method of Sn-113 / In-113m generator, comprises the steps:

[0032] 1) In the container, add pH = 0.5, a volume of 1 mL tin chloride with a radioactive concentration of 1.85 GBq / mL [ 113Sn] aqueous solution, add 1mL, 6M sulfuric acid aqueous solution, add 1.5mL mass concentration 99% liquid bromine aqueous solution, then use 1M sulfuric acid aqueous solution to adjust the radioactive concentration to 185MBq / mL;

[0033] 2) A support frame 9 is set in the lead protection tank 7, and the support frame is connected with the heating sheet 4; the heating sheet 4 is connected with the power plug 5;

[0034] 3) Get a glass separation column with a diameter of 6mm and a length of 140mm, set a sieve plate 1 at the bottom of the glass separation column, put 1mm thick glass wool on the sieve plate 1, and then put 6g of nano zirconia particles, nano zirconia The particle size of the microparticles is 20nm, vibrating while feeding, one end of the liquid inlet pi...

Embodiment 3

[0038] A kind of preparation method of Sn-113 / In-113m generator, comprises the steps:

[0039] 1) In the container, put pH=2, volume is 1mL the tin chloride that radioactive concentration is 3.7GBq / mL[ 113 Sn] aqueous solution, add 6mL, 1M nitric acid aqueous solution, add 2.5mL liquid bromine aqueous solution with a mass concentration of 99%, and then use 1M nitric acid aqueous solution to adjust the radioactive concentration to 370MBq / mL;

[0040] 2) A support frame 9 is set in the lead protection tank 7, and the support frame is connected with the heating sheet 4; the heating sheet 4 is connected with the power plug 5;

[0041] 3) Take a glass separation column with a diameter of 9mm and a length of 100mm, set a sieve plate 1 at the bottom of the glass separation column, put 1mm thick glass wool on the sieve plate 1, then put 5g of nano zirconia particles, nano zirconia The particle diameter of the microparticles is 10nm, vibrating while feeding, one end of the liquid inle...

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Abstract

The invention discloses a Sn-113 / In-113m generator and a preparation method. The preparation method comprises the following steps: 1), adding bromine water to stannic chloride [113Sn] aqueous solution, and adjusting the radioactive concentration through acid aqueous solution; 2), setting a support in a lead protection tank, enabling the support to be connected with a heating piece, and enabling the heating piece to be connected with a power plug; 3), placing nano-zirconia particles into a glass separation column, adding the liquid obtained at step 1) from a liquid incoming pipe, carrying out the drip washing through sodium chloride aqueous solution, placing the glass separation column with the absorption Sn [113Sn] nano-zirconia particles in a device obtained at step 2) after drip washing, and enabling the heating piece to make contact with the external surface of the central part of the glass separation column. The method is high in efficiency of drip washing, is low in breakthrough rate, and is small in drip washing volume. The method is high in speed of drip washing, can enable a worker to shorten the operation time as much as possible, and reduces the irradiation risks.

Description

technical field [0001] The invention relates to a preparation method of a medical or industrial radionuclide generator, and more specifically relates to a preparation method of a Sn-113 / In-113m generator. Background technique [0002] The radionuclide generator is also called the cow. It uses the difference in the distribution of the parent nuclide and the daughter nuclide in the adsorbent, and prepares a device with a shorter half-life daughter radionuclide through a longer half-life parent radionuclide. The radionuclide required for medical or industrial applications is continuously washed from the radionuclide generator. At present, the widely used radionuclide is molybdenum[ 99 Mo] / Technetium[ 99m Tc] generator, tin[ 113 Sn] / Indium[ 113m In] generator and strontium [ 90 Sr] / Yttrium[ 90 Y] generator etc. Radionuclide indium[ 113m In] has good chemical and nuclear properties, a half-life of 99.8min, and a gamma energy of 391keV. It is an important nuclide widely use...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G21G4/04G21G4/06
CPCG21G4/04G21G4/06
Inventor 阎尓坤白红升
Owner 天津汇康药业有限公司
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