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Azithromycin medicinal composition applicable to children

A technology for azithromycin, which is taken by children, is applied in the field of medicine and can solve the problems of delayed onset of action and complicated process

Inactive Publication Date: 2017-11-07
天津双硕医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Although many technical solutions to solve the bitterness of azithromycin granules are disclosed in the prior art, the process is complicated. Generally, it is prepared into enteric-coated granules or pellets, and then sweeteners are added, so as to solve the problem of azithromycin The problem of degradation in gastric acid, and at the same time solve the problem of bitterness through coating, but the process is complicated, and the onset time of enteric-coated preparations is delayed compared with ordinary gastric-coated preparations

Method used

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  • Azithromycin medicinal composition applicable to children
  • Azithromycin medicinal composition applicable to children
  • Azithromycin medicinal composition applicable to children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1 Preparation of 500mg specification azithromycin granules (unit: g)

[0078] prescription:

[0079]

[0080] The pharmaceutical composition containing azithromycin is further prepared into granules by the following steps:

[0081] 1) Take azithromycin bulk drug, sucralose, and citric acid to pulverize, pass through a 200-mesh sieve, and set aside;

[0082] 2) Take the prescription amount of sucralose, microcrystalline cellulose, stearyl alcohol and the slow-release material hypromellose K15M, mix evenly, granulate with 95% ethanol, spheroidize, and dry to obtain the slow-release sweetener granules;

[0083] 3) Take the prescribed amount of azithromycin raw material, citric acid, mix evenly, granulate with purified water, dry, sieve and granulate with 40 mesh to obtain drug-loaded granules;

[0084] 4) Take the prescribed amount of azithromycin drug-loaded granules, slow-release sweetener, and glidant colloidal silicon dioxide, and mix evenly to obtain the ...

Embodiment 2

[0085] Example 2 Preparation of 1000mg Azithromycin Granules (Unit: g)

[0086] prescription:

[0087]

[0088] The pharmaceutical composition containing azithromycin is further prepared into granules by the following steps:

[0089] 1) Take azithromycin bulk drug, sucralose, and citric acid to pulverize, pass through a 200-mesh sieve, and set aside;

[0090] 2) Take the prescription amount of sucralose, microcrystalline cellulose, stearyl alcohol and the slow-release material hypromellose K15M, mix evenly, granulate with 95% ethanol, spheroidize, and dry to obtain the slow-release sweetener granules;

[0091] 3) Take the prescribed amount of azithromycin raw material, citric acid, mix evenly, granulate with purified water, dry, sieve and granulate with 40 mesh to obtain drug-loaded granules;

[0092] 4) Take the prescribed amount of azithromycin drug-loaded granules, slow-release sweetener, and glidant colloidal silicon dioxide, and mix evenly to obtain the azithromycin ...

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PUM

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Abstract

In the research process of azithromycin preparations, the inventor finds that macrolide antibiotics such as azithromycin are bitter for people because of residues of medicinal molecules in mouths, and on the basis of elimination of the bitterness of residual azithromycin, the inventor tries a method that a sweetening agent such as cane sugar and sucralose can be taken after people still feel bitter after taking bitter azithromycin granules, and then the bitter taste can be remarkably inhibited. On the basis, the inventor tries to prepare sucralose into slow-release granules, when the azithromycin granules are taken, the sucralose can be slowly released, then the purpose of eliminating the bitter taste of the residual azithromycin in mouths can be achieved, and tests show that a good effect can be achieved.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition of azithromycin suitable for children and its preparation method and application. Background technique [0002] Bronchitis refers to the formation of trachea, trachea, Chronic non-specific inflammation of the bronchial mucosa and its surrounding tissues, clinically characterized by long-term cough, expectoration or accompanied by wheezing and recurrent attacks. According to different symptoms, bronchitis is divided into two types: chronic bronchitis and acute bronchitis. Among them, acute bronchitis is characterized by runny nose, fever, cough, and sputum as the main symptoms, accompanied by hoarseness, sore throat, and slight retrosternal friction pain. The initial sputum is less viscous and becomes purulent later, with smoke and cold air. Other stimuli can aggravate cough; chronic bronchitis mainly manifests as long-term cough, espec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7052A61K47/26A61K47/12A61K47/38A61P11/00A61P31/04A61P31/12
CPCA61K9/1623A61K9/0002A61K9/1617A61K9/1652A61K31/7052
Inventor 不公告发明人
Owner 天津双硕医药科技有限公司