Paecilomyces hepiali fermentation culture for treating type 1 or type 2 diabetes mellitus

A technology of Paecilomyces bat moth and type 2 diabetes, applied in the field of treating type 1 and type 2 diabetes

Inactive Publication Date: 2017-11-14
元龙生技国际股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Since ancient times, Cordyceps sinensis has been considered as a health treasure and may be helpful for diabetes. At present, the existing technology believes that taking Cordyceps oral liquid can prevent or treat diabetes, but most of them are directly processed from fruiting bodies or mycelium. For those with sensitive constitutions Taking Cordyceps sinensis may cause side effects such as dry mouth, nausea, and diarrhea. Some fruiting bodies of Cordyceps sinensis have even been found to contain heavy metals and pesticides. Fermentation products can be obtained, which may solve the above problems

Method used

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  • Paecilomyces hepiali fermentation culture for treating type 1 or type 2 diabetes mellitus
  • Paecilomyces hepiali fermentation culture for treating type 1 or type 2 diabetes mellitus
  • Paecilomyces hepiali fermentation culture for treating type 1 or type 2 diabetes mellitus

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Effects of Fermentation Products of Paecilomyces hematalis on Soybean Solid Media on Blood Sugar

[0042] Take 100 grams of soybeans (soy), soak them in 2 to 3 times the volume of water for 4 hours at 4°C, add 100 ml of 0.1% (w / v) KH containing 2% (w / v) peptone 2 PO 4 solution, sterilized at 121° C. and 1.5 atmospheric pressure for 30 minutes, and when the temperature dropped to room temperature, put 3 ml of Paecilomyces spp. Inoculate, place at 17°C for 20 days, then freeze-dry the fermentation product of soybean solid medium and grind it into powder, which is soybean fermentation powder, and prepare soybean fermentation powder with sterilized reverse osmosis water to obtain soybean fermentation bacteria The powder solution was used for subsequent animal experiments. Rats were fed with soybean fermented bacteria powder solution (60mg / kg), and then 30 minutes later, glucose solution (0.5g / kg) was injected intraperitoneally, and tail vein blood was collected at 0, 30, ...

Embodiment 2

[0044] Effects of Fermentation Products of Paecilomyces hematalis in Black Bean Solid Medium on Blood Glucose

[0045] Take 100 grams of black beans, soak them in 2 to 3 times the volume of water at 4°C for 4 hours, add 100 milliliters of 0.1% (w / v) KH containing 2% (w / v) peptone 2 PO 4 The solution was sterilized at 121° C. and 1.5 atmospheric pressure for 30 minutes. When the temperature dropped to room temperature, 3 milliliters of Paecilomyces spp. Inoculate and place at 17°C for 20 days, then freeze-dry the fermented product of black soybean solid medium and grind it into powder, which is the black soybean fermentation powder, and prepare the black soybean fermentation powder with sterilized reverse osmosis water for subsequent animals experiment. Rats were fed with black soybean fermented bacteria powder solution (60mg / kg), and then 30 minutes later, glucose solution (0.5g / kg) was injected intraperitoneally, and tail vein blood was collected at 0, 30, 60, 90, and 120 m...

Embodiment 3

[0047] Effects of Fermentation Products of Paecilomyces hematalis on Blood Glucose in Rice Solid Media

[0048] Take 100 grams of rice (rice), soak it with 2 to 3 times the volume of water for 4 hours at 4°C, add 100 ml of 0.1% (w / v) KH containing 2% (w / v) peptone 2 PO 4 The solution was sterilized at 121° C. and 1.5 atmospheric pressure for 30 minutes. When the temperature dropped to room temperature, 3 milliliters of Paecilomyces spp. (purchased from China General Microorganism Culture Collection and Management Center, No. CGMCC3.7908) was added for inoculation. Place it at 17°C for 20 days, then freeze-dry the fermentation product of rice solid medium and grind it into powder, which is rice fermentation powder, and prepare rice fermentation powder with sterilized reverse osmosis water to make rice fermentation powder solution for subsequent animal experiments. Rats were fed with rice fermented bacteria powder solution (60mg / kg), and then 30 minutes later, glucose solution...

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Abstract

The invention discloses a medical composition for treating type 1 or type 2 diabetes mellitus and a preparation method thereof. The medical composition is prepared from a solid or liquid fermentation culture of paecilomyces hepiali.

Description

technical field [0001] The invention relates to a kind of fermentation product of Paecilomyces hematalis to treat type 1 and type 2 diabetes. Background technique [0002] Diabetes is a metabolic disease. Diabetes is a chronic disease caused by the inability of the beta cells of the islets (Islands of Langerhans) to secrete enough insulin hormone, or the insensitivity of cells to insulin due to obesity. [0003] Insulin is produced by the beta cells of the pancreas and converts glucose into glycogen. When insulin production decreases or its efficacy decreases, the glycogen produced decreases, resulting in decreased glucose utilization by peripheral tissues, and slows down the removal of glucose from blood circulation. Glucose concentration increases, resulting in hyperglycemia. Excessive blood sugar cannot be completely reabsorbed by the renal tubules, so the concentration of glucose in the urine increases, which is called glycosuria; insulin acts on the liver, muscle cells,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P3/10C12N1/14C12R1/79
CPCA61K9/4841A61K36/068C12N1/14
Inventor 苏贻棱
Owner 元龙生技国际股份有限公司
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