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Antimicrobial alginate fiber as well as preparation method and application of antibacterial alginate fiber dressing

An antibacterial alginate and alginate fiber technology, applied in fiber treatment, natural fiber, biochemical fiber treatment and other directions, can solve the problems of adverse drug resistance, adverse side effects, high honey addition, and high safety risks, and achieve antibacterial The effect of long-term aging, low dissolution rate and safety risk reduction

Active Publication Date: 2017-11-24
HUIZHOU HUAYANG MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drug resistance and other potential adverse side effects
[0007] Chinese patent CN105536041A and U.S. patent US7,714,183 disclose an antibacterial alginate composite dressing containing honey, which has good anti-infection effect, but the amount of honey added is high and the cost is high
In addition, polyhexamethylene biguanide hydrochloride loaded on alginate by conventional impregnation method is very easy to dissolve in water, and the content of polyhexamethylene biguanide hydrochloride used in this technology is very high (0.5%-10 %), high security risk

Method used

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  • Antimicrobial alginate fiber as well as preparation method and application of antibacterial alginate fiber dressing
  • Antimicrobial alginate fiber as well as preparation method and application of antibacterial alginate fiber dressing
  • Antimicrobial alginate fiber as well as preparation method and application of antibacterial alginate fiber dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0048] A kind of preparation method of antibacterial alginate fiber dressing, take 1000g of short fiber alginate of 3 ~ 5cm, put it into 5000g containing 0.54% hydrochloric acid, 9.5% ethanol aqueous solution at 20 ℃, stir and activate for 3.0 hours, centrifuge to separate the liquid, Then 2000 grams of absolute ethanol soaked the fibers for 10 to 15 minutes, centrifuged to separate the ethanol to obtain primary activated alginate fibers; Phenylphosphine: 0.235%, iodine: 0.228%), and start the stopwatch timing, after stirring for 1-2 minutes, put an activated alginate fiber into the solution, stir for 3-5 minutes, activate at 35°C for 30 minutes, Then take out the fiber, squeeze the separation solution to obtain the secondary activated fiber; then mix and stir 4000 g of the PHMB ethanol solution with a mass concentration of 0.028% and the secondary activated fiber at 25°C for 40 minutes, press the separation solution and put the fiber into the previous Stir and react in chloro...

Embodiment 2

[0051] A kind of preparation method of antibacterial alginate fiber dressing, take 1000g of short fiber alginate of 3 ~ 5cm, put it into 5000g containing 0.54% hydrochloric acid, 9.5% ethanol aqueous solution at 20 ℃, stir and activate for 3.0 hours, centrifuge to separate the liquid, Then 2000 grams of absolute ethanol soaked the fibers for 10 to 15 minutes, centrifuged to separate the ethanol to obtain primary activated alginate fibers; Phenylphosphine: 0.235%, iodine: 0.228%), and start the stopwatch timing, after stirring for 1-2 minutes, put an activated alginate fiber into the solution, stir for 3-5 minutes, activate at 35°C for 30 minutes, Then take out the fiber, squeeze the separation solution to obtain the secondary activated fiber; then mix and stir 4000 g of the PHMB ethanol solution with a mass concentration of 0.038% and the secondary activated fiber at 25° C. for 40 minutes, press the separation solution and put the fiber into the previous Stir and react in chlo...

Embodiment 3

[0054] A preparation method of antibacterial alginate fiber dressing, take 1000g of long filament fiber alginate, put it into 5000g containing 0.54% hydrochloric acid, 9.5% ethanol aqueous solution at 20 ℃, stir and activate for 3.0 hours, centrifuge to separate the liquid, and then 2000g Wet the fibers with absolute ethanol for 10-15 minutes, and centrifuged the ethanol to obtain primary activated alginate fibers; 110g of N,N-diisopropylethylamine was added to 5500g of chloroform solution (triphenylphosphine) under stirring at 70r / min : 0.235%, iodine: 0.228%), and start the stopwatch timing, after stirring for 1 to 2 minutes, put an activated alginate fiber into the solution, stir for 3 to 5 minutes, activate at 35°C for 30 minutes, and then take out the fiber , squeeze the separation solution to obtain secondary activated fibers; then mix and stir 4000 g of PHMB ethanol solution with a mass concentration of 0.052% and the secondary activated fibers at 25°C for 40 minutes, an...

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Abstract

The invention provides an antimicrobial alginate fiber as well as a preparation method and application of an antimicrobial alginate fiber dressing. According to the invention, the technical difficult problem that the antimicrobial activity of guanidine salt is quickly passivated after polyhexamethyleneguanidine salt as a cationic polymer is mixed with alginate as an anionic polymer is solved, and good and long-term antimicrobial activity of a polyhexamethyleneguanidine alginate fiber with relatively-low content and a medical product are realized. The polyhexamethyleneguanidine salt is low in dissolution rate and provides good safety, so that potential risks of carcinogenesis, mutagenesis and reproductive toxicity are remarkably reduced.

Description

technical field [0001] The invention relates to the field of wound care or wound healing medicine, more specifically, the invention relates to an antibacterial alginate fiber, a preparation method and application of the dressing. Background technique [0002] After the alginate dressing absorbs the wound exudate, it can form a soft gel, which provides an ideal moist environment for wound healing, promotes wound healing, and relieves wound pain. It has the advantages of safety, non-toxicity, high hygroscopicity, hemostasis, gelation, and promotion of wound healing, and is widely used in the field of wound care. However, there are disadvantages such as weak antibacterial performance. [0003] Polyhexamethylene biguanide salt contains strong positive charge, adsorbs various bacteria and viruses that are usually negative charge, enters the cell membrane, inhibits the synthesis of liposomes in the membrane, causes cell apoptosis, and achieves excellent bactericidal effect. It...

Claims

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Application Information

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IPC IPC(8): D06M15/37D06M11/11D06M13/08D06M16/00A61L15/28A61L15/42A61L15/44A61L15/46D06M101/02
CPCA61L15/28A61L15/42A61L15/44A61L15/46A61L2300/204A61L2300/404D06M11/11D06M13/08D06M15/37D06M16/006D06M2101/02C08L5/04
Inventor 孟永刚莫晋文
Owner HUIZHOU HUAYANG MEDICAL EQUIP
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