3D printed composite scaffold as well as preparation method and application thereof

A 3D printing and binary composite technology, applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problems of affecting osteogenic performance, hindering host osseointegration, lack of promotion of bone tissue regeneration, etc., to improve the degradation rate, Improve hydrophilic performance and good in vitro biological activity

Inactive Publication Date: 2017-12-01
上海禾麦医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PBSu also has disadvantages, such as PBSu is a hydrophobic material, which will affect the cell adhesion behavior on the surface of PBSu; PBSu is also a biologically inert material, which will hinder its combination with the host bone, affect its osteogenic performance, and lack the ability to regenerate bone tissue. significant promotion of
[0004] Although the above-mentioned single repair material has certain advantages, the disadvantages of the scaffold made of a single material are also obvious. Therefore, there is an urgent need in this field for a composite scaffold with uniform material pores, high mechanical strength, simple manufacture, and suitable degradation rate.

Method used

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  • 3D printed composite scaffold as well as preparation method and application thereof
  • 3D printed composite scaffold as well as preparation method and application thereof
  • 3D printed composite scaffold as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Example 1 Preparation of Mesoporous Magnesium Silicate / Polybutylene Succinate Binary Composite Scaffold (S2)

[0084] (1) Preparation of mesoporous magnesium silicate (m-MS)

[0085] The m-MS of this embodiment is prepared by the following method:

[0086]Put a mixed solution of 30mL deionized water and 120mL 2.0M dilute hydrochloric acid in a 50°C water bath. Then, accurately weigh 4.0 g of P123, add it into the above mixed solution, and stir for 30 minutes until clear. Subsequently, 4.8 g of magnesium nitrate hexahydrate and 8.5 g of ethyl orthosilicate were successively weighed and added to the above clear solution, and stirred for 5 hours. After standing still, filter with suction, wash with deionized water, and filter with suction again. After repeating 3 times, place in a 60°C electric blast drying oven to obtain a white powder. The powder was put into a stainless steel mold, and a disc sample (Φ12×2mm) was prepared under a pressure of 2MPa using a tablet press...

Embodiment 2

[0089] Example 2 Preparation of Mesoporous Magnesium Silicate / Polybutylene Succinate / Gliadin Ternary Composite Scaffold (S3)

[0090] (1) Preparation of mesoporous magnesium silicate (m-MS)

[0091] The m-MS of this embodiment is prepared by the following method:

[0092] Put a mixed solution of 30mL deionized water and 120mL 2.0M dilute hydrochloric acid in a 50°C water bath. Then, accurately weigh 4.0 g of P123, add it into the above mixed solution, and stir for 30 minutes until clear. Subsequently, 4.8 g of magnesium nitrate hexahydrate and 8.5 g of ethyl orthosilicate were successively weighed and added to the above clear solution, and stirred for 5 hours. After standing still, filter with suction, wash with deionized water, and filter with suction again. After repeating 3 times, place in a 60°C electric blast drying oven to obtain a white powder. The powder was put into a stainless steel mold, and a disc sample (Φ12×2mm) was prepared under a pressure of 2MPa using a ta...

Embodiment 3

[0095] Example 3 Preparation of Mesoporous Magnesium Silicate / Polybutylene Succinate Binary Composite Scaffold (S4)

[0096] (1) Preparation of mesoporous magnesium silicate (m-MS)

[0097] The m-MS of this embodiment is prepared by the following method:

[0098] Put a mixed solution of 30mL deionized water and 120mL 2.0M dilute hydrochloric acid in a 50°C water bath. Then, accurately weigh 4.0 g of P123, add it into the above mixed solution, and stir for 30 minutes until clear. Subsequently, 4.8 g of magnesium nitrate hexahydrate and 8.5 g of ethyl orthosilicate were successively weighed and added to the above clear solution, and stirred for 5 hours. After standing still, filter with suction, wash with deionized water, and filter with suction again. After repeating 3 times, place in a 60°C electric blast drying oven to obtain a white powder. The powder was put into a stainless steel mold, and a disc sample (Φ12×2mm) was prepared under a pressure of 2MPa using a tablet pres...

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Abstract

The invention discloses a 3D printed composite scaffold as well as a preparation method and an application thereof. The 3D printed composite scaffold comprises a mesoporous magnesium silicate / PBSu (poly(butylene succinate)) binary composite scaffold and a mesoporous magnesium silicate / PBSu / gliadin ternary composite scaffold, wherein the binary composite scaffold is prepared from mesoporous magnesium silicate and PBSu in the content ratio being (1:1)-(1:5), and the pore size of the scaffold is 300-500 mu m; the ternary composite scaffold is prepared from mesoporous magnesium silicate, PBSu and gliadin in the content ratio being (1:1:1)-(5:5:1), and the pore size of the scaffold is 300-500 mu m. The composite scaffold has better in-vitro bioactivity, the hydrophilic performance of the material is improved, and the decomposition rate of the scaffold is effectively increased; the 3D printed composite scaffold shows better cell proliferation promoting and osteogenic differentiation capability, and has better application prospects in the field of preparation of bone defect repair materials.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to a 3D printing composite bracket and a preparation method and application thereof. Background technique [0002] Bones are an important part of the human body, have certain mechanical properties, and play a role in supporting the human body. However, due to external trauma, bone diseases (bone tumors, osteomyelitis, etc.) and infection, bone defects are common and difficult to completely repair in clinical practice. Therefore, research on bone repair and replacement materials is of great significance. An ideal bone repair material should have biomimetic physical structure, chemical composition and biodegradable properties. [0003] In recent years, the research of mesoporous magnesium silicate for bone defect repair has received extensive attention. Mesoporous material is a new type of nanostructure functional material, which has good biological activity, can pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/56A61L27/02A61L27/18A61L27/22
CPCA61L27/025A61L27/18A61L27/227A61L27/56A61L27/58A61L2430/02C08L67/025C08L89/00
Inventor 苏佳灿苏奕铭魏杰
Owner 上海禾麦医学科技有限公司
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