Composite material for making degradable ureteral stent and application thereof

A ureteral stent tube and composite material technology are applied in the field of degradable ureteral stent tube composite materials, which can solve the problems of large friction between the ureteral stent and the ureteral wall, slow degradation of composite materials, and excessive degradation time, and achieve excellent physiological inertia and Biocompatibility, wet friction reduction, effect of increasing degradation rate

Active Publication Date: 2013-04-17
ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Foreign literature reports (Laaksovirta, S Laurila M.et al.Jurol, 167: 1527, 2002) use degradable lactide-co-glycolide (PLGA) as the original composite material to manufacture ureteral stents. The disadvantage of the stent tube is that the molecular weight is too low, the degradation time is too fast, the supporting effect can only last for about a week, and the composite material is a typical plastic body, which is relatively hard and has poor elasticity
[0005] Chinese patent application CN101212937A discloses a fiber-reinforced composite absorbable ureteral stent. The absorbable composite material in this patent application can be made of L-lactide / ε-caprolactone. When implanted, the ureteral stent and ureter High wall friction makes implantation difficult, and the composite material degrades too slowly during indwelling in the body, and debris formed during the degradation process may block the ureter

Method used

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  • Composite material for making degradable ureteral stent and application thereof
  • Composite material for making degradable ureteral stent and application thereof
  • Composite material for making degradable ureteral stent and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Put 180 grams of ε-caprolactone monomer and 320 grams of L-lactide that have been dehydrated and purified into a 2500ml reaction bottle, then add 0.01% stannous octoate catalyst, and react under vacuum at 150°C for 8 hours , to obtain an elastic copolymer, the copolymer was dissolved in acetone, precipitated with ethanol, and the precipitate was dried in a vacuum dryer for 48 hours to obtain the L-lactide / ε-caprolactone copolymer elastomer composite material. The molecular weight of the product is measured by gel permeation chromatography (GPC) and the weight average molecular weight is 380,000. Through nuclear magnetic 1H spectrum measurement, the mol ratio of L-lactide and ε-caprolactone structural unit in this polymer is 75: 25 , The glass transition temperature (Tg) of the L-lactide / ε-caprolactone copolymer measured by differential scanning calorimetry was 0.67°C.

[0028] 10 grams of cross-linked polyvinylpyrrolidone (particle size 5 ~ 50 μm, commercial brand: Poly...

Embodiment 2

[0030]150 grams of ε-caprolactone monomer and 350 grams of L-lactide treated by dehydration and purification are placed in a 2500ml reaction bottle, and then 0.01% stannous octoate catalyst is added, and reacted under vacuum conditions at 150°C for 6 hours to obtain Elastic copolymer, the copolymer is dissolved in acetone, precipitated with ethanol, and the precipitate is dried in a vacuum dryer for 48 hours to obtain the L-lactide / ε-caprolactone copolymer elastomer composite material. The molecular weight of the product is measured by gel permeation chromatography (GPC) and the weight average molecular weight is 455,000. Measured by nuclear magnetic 1H spectrum, the mol ratio of L-lactide and ε-caprolactone structural unit in the polymer is 80:20 , The glass transition temperature (Tg) of the L-lactide / ε-caprolactone copolymer measured by differential scanning calorimetry was 7°C. Using a melt blending method, using a twin-screw extruder, under the condition of 155 ° C, prepa...

Embodiment 3

[0033] 200 grams of ε-caprolactone monomer and 350 grams of L-lactide that were dehydrated and purified were placed in a 2500ml reaction bottle, and then 0.01% stannous octoate catalyst was added, and reacted at 150°C for 8 hours under vacuum conditions to obtain Elastic copolymer, the copolymer is dissolved in acetone, precipitated with ethanol, and the precipitate is dried in a vacuum dryer for 48 hours to obtain the L-lactide / E-caprolactone copolymer elastomer composite material. The molecular weight of product is measured by gel permeation chromatography (GPC) and is 330,000 average molecular weights, and through nuclear magnetic 1H spectrum measurement, the mol ratio of L-lactide and ε-caprolactone structural unit in this polymer is 73: 27 , The glass transition temperature (Tg) of the L-lactide / E-caprolactone copolymer measured by differential scanning calorimetry was -1°C. With the solution blending method, with reference to the steps of Example 1, prepare L-lactide / ε-c...

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Abstract

The invention provides a kind of composite material for making a degradable ureteral stent, comprising: 60-98% by weight of L-lactide/ Epsilon-caprolactone copolymer, and 2-40% by weight of polyvinylpolypyrrolidone. The L-lactide/ Epsilon-caprolactone copolymer in the composite material is elastomeric material with good biocompatibility, and the polyvinylpolypyrrolidone can reduce a surface friction coefficient of the prepared degradable ureteral stent, and simultaneously raises the degradation speed of the degradable ureteral stent. The invention also discloses a degradable ureteral stent prepared by the composite material. The degradable ureteral stent has good biocompatibility, is easy to degrade, and can be used in an operation in urinary surgery.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a composite material used for a degradable ureteral stent and an application thereof. Background technique [0002] Ureteral stent (double pigtail catheter, or D-J tube) is widely used in urological surgery, and is suitable for upper urinary tract surgery, lithotripsy, ureteral stricture expansion and other treatment processes. After it is implanted in the ureter, it can It plays an important role in draining urine and preventing ureteral stricture and adhesion blockage. At present, most of the ureteral stents in clinical use are made of silicone rubber or polyurethane polymer composite materials that cannot be degraded in the human body, and there are some insurmountable defects in clinical application, such as: they must be removed through invasive operations, that is, through cystoscopy. Although this type of cystoscopic operation is not considered a major oper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/18A61F2/82
Inventor 陈和春张大宏熊成东庞秀炳陈栋梁
Owner ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL
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