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Synthesis method of molecularly imprinted composite membrane capable of enriching and separating norfloxacin

A technology of norfloxacin and molecular imprinting, applied in chemical instruments and methods, semi-permeable membrane separation, membrane technology, etc., can solve the problems of poor binding kinetics, deep embedding of active sites, and poor binding ability and other problems, to achieve fast adsorption kinetic properties, reduce non-specific adsorption, and not easy to damage

Inactive Publication Date: 2017-12-15
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, molecularly imprinted composite membranes (MICMs) have gradually attracted more and more attention because they can solve the shortcomings of MIPs materials, such as poor binding ability, poor binding kinetics, deep embedding of active sites, and secondary pollution caused by non-recycling. More and more scientists are paying attention

Method used

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  • Synthesis method of molecularly imprinted composite membrane capable of enriching and separating norfloxacin
  • Synthesis method of molecularly imprinted composite membrane capable of enriching and separating norfloxacin
  • Synthesis method of molecularly imprinted composite membrane capable of enriching and separating norfloxacin

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Embodiment 1

[0045] figure 1 : Schematic diagram of the synthesis process of norfloxacin molecularly imprinted composite membrane.

[0046] (1) Preparation of titanium dioxide nanoparticles

[0047] In a one-necked flask, add 0.25 g TiN powder, 60 mL water, 8 mL H 2 o 2 and 8 mL NH 3 •H 2 The mixed solution of O was stirred for 1 hour; then 40 mL of the obtained mixed solution was mixed with 100 mL of ethanol and stirred for reflux reaction for 12 hours; after the reaction, the synthesized product was centrifuged, washed several times with ethanol, and vacuum-dried for later use.

[0048] (2) Preparation of molecularly imprinted nanocomposite particles

[0049] In a single-necked flask, 0.2 g of titanium dioxide nanoparticles was dispersed into 50 mL of tris-HCl (Tris-HCl) aqueous solution at pH=8.5, and norfloxacin (0.2 g) was added, stirred for 1 hour, and then After adding dopamine (0.1 g) and stirring continuously at room temperature, the mixture was centrifuged, washed repeatedl...

Embodiment 2

[0066] (1) Preparation of titanium dioxide nanoparticles

[0067] In a one-necked flask, add 0.5g TiN powder, 120 mL water, 16 mL H 2 o 2 and 16 mL NH 3 •H 2 The mixed solution of O was stirred for 1 hour; then 80 mL of the obtained mixed solution was mixed with 200 mL of ethanol and stirred under reflux for 12 hours; after the reaction, the synthesized product was centrifuged, washed several times with ethanol, and vacuum-dried for later use.

[0068] (2) Preparation of molecularly imprinted nanocomposite particles

[0069] In a single-necked flask, firstly disperse 0.4 g of titanium dioxide nanoparticles into 100 mL of tris-HCl (Tris-HCl) aqueous solution with pH=8.5, add norfloxacin (0.4 g), stir for 1 hour, and then add Dopamine (0.2 g) was continuously stirred and reacted at room temperature, then centrifuged, washed repeatedly with ethanol and water to remove unreacted reactants, and the obtained molecularly imprinted polymer was dried for later use.

[0070] (3) Pr...

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Abstract

The invention discloses a synthesis method of a molecularly imprinted composite membrane capable of enriching and separating norfloxacin, and belongs to the technical field of a new material. The molecularly imprinted composite membrane is synthesized mainly through three-step reaction. The synthesis method comprises the following steps: firstly, synthesizing titanium dioxide nanoparticles; secondly, on the substrate of the titanium dioxide, synthesizing a norfloxacin molecularly imprinted polymer by taking the norfloxacin as a template molecule, taking dopamine as a functional monomer and a crosslinking agent and combining with a dopamine bionic principle; finally, performing suction filtration on the molecularly imprinted polymer on the membrane by taking a regenerated cellulose membrane as a matrix material and through a vacuum suction filtration method for detecting the residual norfloxacin in water. The preparation method provided by the invention has the characteristics of simplicity and convenience in operation, easiness in implementation, high yield, middle reaction condition and the like, and is expected to be applied to industrial production. In addition, static adsorption and selective permeation experimental results indicate that the prepared molecularly imprinted composite membrane has high separation property and high selectivity.

Description

technical field [0001] The invention relates to the preparation and application of a high-performance norfloxacin imprinted composite film, which belongs to the technical field of new materials. Background technique [0002] China is the largest producer and user of antibiotics in the world, but the abuse of antibiotics pollutes the human environment, and the bacterial resistance caused by the abuse of antibiotics has become a public health problem that seriously threatens human health. Norfloxacin, a quinolone antibiotic, is widely used in human and livestock therapy and in aquaculture. Most of norfloxacin cannot be metabolized by humans and animals at all, resulting in its final discharge into the environment. Since norfloxacin cannot be completely absorbed by the human body or animals, a large part of it is excreted into the environment with feces and urine in the form of original or metabolites. impact, and may ultimately have adverse effects on human health and surviva...

Claims

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Application Information

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IPC IPC(8): B01D71/82B01D69/12B01D67/00B01J20/26B01J20/28B01J20/30C08G73/06C08K3/22C08J9/26
CPCB01D67/0002B01D69/12B01D71/82B01J20/268B01J20/28033C08G73/0672C08J9/26C08J2201/0424C08J2379/04C08K3/22C08K2003/2241
Inventor 赵娟吴易霖王晨卢健闫永胜李春香
Owner JIANGSU UNIV
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