Solubilization system with resveratrol
A technology of resveratrol and system, applied in the field of solubilization system, can solve problems such as inability to use transparent preparations, difficult preparations, poor efficacy, etc.
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Examples
Embodiment 1～5、 comparative example 1～9
[0056] According to the formula shown in Table 1, accurately weigh the solubilizer, add it to the co-solvent, heat to 40-50°C, stir and disperse evenly. Add resveratrol into the above solubilizer and co-solvent mixture, heat to 60°C, and stir evenly. At room temperature, slowly add deionized water into the above solution, and stir slowly until the system is completely uniform.
Embodiment 6
[0058] The samples in Examples 1 to 5 and Comparative Examples 1 to 9 were left standing for a week at room temperature and protected from light, and observed whether there was precipitation in the samples before and after standing. unstable).
[0059] Table 1
[0060]
[0061] As can be seen from the data of Examples 1 to 5 and Comparative Examples 1 to 3, since the solubilizers contained in Examples 1 to 5 all include polyoxyethylene chain segments, they can dissolve resveratrol well and improve the performance of resveratrol. The stability of revertitol in the formula prevents it from separating out. However, in Comparative Examples 1 to 3, the structure of the solubilizer does not contain polyoxyethylene segment, and resveratrol is unstable in the sample and will be directly precipitated.
[0062] From the data of Example 5 and Comparative Examples 4 to 9, it can be seen that in Comparative Example 4 without using a co-solvent, the simple solubilizer can play a solubi...
Embodiment 7
[0065] Embodiment 7, Comparative Examples 10-12 :
[0066] Accurately weigh the solubilizer according to the formula shown in Table 2, add it into the co-solvent, heat to 40-50°C, stir and disperse evenly. Add resveratrol into the above solubilizer and co-solvent mixture, heat to 60°C, and stir evenly. At room temperature, slowly add deionized water into the above solution, and stir slowly until the system is completely uniform.
[0067] Table 2
[0068]
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