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Preparation method of pluronic F127 curcumin liposome

A technology of curcumin lipid and curcumin, applied in the field of Pluronic F127 curcumin liposome and its preparation, can solve problems such as larger particle size, drug leakage, instability and the like

Inactive Publication Date: 2017-12-22
JIANGXI SCI & TECH NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, traditional liposomes are unstable during storage, and have problems such as particle aggregation, particle size enlargement, and drug leakage.

Method used

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  • Preparation method of pluronic F127 curcumin liposome
  • Preparation method of pluronic F127 curcumin liposome
  • Preparation method of pluronic F127 curcumin liposome

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0023] 1. Weigh 0.1006g of phospholipids, 0.0198g of cholesterol, 0.0250g of Pluronic F127 and 0.0049g of curcumin and dissolve them completely in 20mL of absolute ethanol, and remove the absolute ethanol by rotary evaporation in a water bath at 45°C to form a uniform film. Add 50mL deionized water for hydration for 30min, and the formed suspension is crude liposome. The suspension was subjected to DHPM treatment for 2 times, and the pressure was 120Mpa to obtain Pluronic F127 curcumin liposomes.

[0024] 2. Particle size and dispersibility investigation: use a laser nanometer particle size analyzer to measure particle size and dispersibility. The results show that the average particle size of cur-Lps is 94.9nm, the dispersion coefficient is 0.371, the average particle size of cur-F127-Lps is 70.5nm, and the dispersion coefficient is 0.274, the results are as follows figure 2 shown.

[0025] 3. Determination of curcumin encapsulation efficiency: centrifuge cur-F127-Lps at 8...

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Abstract

The invention belongs to the field of biomedicine and particularly relates to a preparation method of pluronic F127 curcumin liposome. The pluronic F127 curcumin liposome is prepared from phospholipid, cholesterol, pluronic F127 and curcumin by means of film dispersion in conjunction with dynamic high-pressure microjet through the treatments such as dissolving, film forming, hydration and dynamic high-pressure microjet. The pluronic F127 curcumin liposome prepared by using the preparation method has particle size of 70.3+ / -1.0 nm, dispersion coefficient of 0.279+ / -0.004, and encapsulation rate of 89.8+ / -0.7%. The pluronic F127 curcumin liposome has the advantages of small particle size, narrow dispersion range and good stability, has good storage stability, and can provide improved in-vitro digestion stability and bioavailability for traditional curcumin liposomes.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a Pluronic F127 curcumin liposome and a preparation method thereof. Background technique [0002] Curcumin is a natural active ingredient extracted from turmeric. Studies in recent years have shown that curcumin has a wide range of pharmacological effects, such as anti-tumor, improving cardiovascular function, anti-inflammation, anti-virus, liver protection, and enhancing immunity. It has good pharmacological activity and application prospects, but curcumin has water-soluble Defects such as poor sex, poor stability, oral bioavailability, and easy metabolism in vivo limit its clinical application. Carrying by nanotechnology is one of the effective means to improve the stability and bioavailability of curcumin. Among them, liposome is a delivery system that has been studied more. [0003] Liposomes are bilayer closed vesicles composed of amphiphilic substances such as phos...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/10A61K31/12A61P35/00A61P9/00A61P29/00A61P31/12A61P1/16A61P37/04
CPCA61K9/1271A61K31/12A61K47/10
Inventor 李资玲熊向源吴光杰龚妍春
Owner JIANGXI SCI & TECH NORMAL UNIV
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