Tendon-relaxing and pain-easing capsule as well as preparation method and application thereof

A capsule and tendon-relieving technology, which is applied in capsule delivery, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of low content of active ingredients and poor therapeutic effect, so as to prevent oxidation and escape, and prevent human body from The existence of harmful substances, the effect of low price

Inactive Publication Date: 2017-12-22
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the traditional Chinese medicine Shujindingtong Capsules (recorded in State Food and Drug Administration YBZ00132009, composed of 45.5g of angelica, 45.5g of vinegar-made frankincense, 75.8g of wood beetle, 45.5g of Rhizoma Drynariae, 45.5g of calcined natural copper in vinegar, and 45.5g of calcined borax 45.5g, safflower 45.5g, vinegar-made myrrh 45.5g, rhubarb 45.5g) are used more, but the therapeutic effect is not very good, and the active ingredient content is not high

Method used

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  • Tendon-relaxing and pain-easing capsule as well as preparation method and application thereof
  • Tendon-relaxing and pain-easing capsule as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: take 150g of Angelica sinensis, 300g of frankincense made from vinegar, 100g of terrestrial soft-shelled turtle, 80g of Rhizoma Drynariae, 10g of natural copper calcined in vinegar, 80g of calcined borax, 10g of safflower, 80g of myrrh made from vinegar, and 10g of rhubarb, the preparation method is: take Angelica, safflower, added to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 30°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, and the extraction time is 150min. The supercritical extract is obtained, which is wrapped with cyclodextrin and used for later use; In the percolation method under the item of extract, 60% ethanol is used as solvent to percolate, and 15 times the amount of percolation solution is collected; ethanol is recovered, concentrated to a relative density of 1.20 at 60°C, spray-...

Embodiment 2

[0018] Example 2: Take 400g of Angelica sinensis, 100g of frankincense made from vinegar, 300g of terrestrial soft-shelled turtle, 10g of Rhizoma Drynariae, 80g of natural copper calcined in vinegar, 10g of calcined borax, 80g of safflower, 10g of myrrh made from vinegar, and 80g of rhubarb, the preparation method is: take Angelica, safflower, added to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 50°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, and the extraction time is 180min. The supercritical extract is obtained, which is wrapped with cyclodextrin and used for later use; In the percolation method under the item of extract, 60% ethanol is used as solvent to percolate, and 15 times the amount of percolation solution is collected; ethanol is recovered, concentrated to a relative density of 1.20 at 60°C, spray-dri...

Embodiment 3

[0019] Example 3: Take 255.5g of Angelica sinensis, 215.5g of frankincense made from vinegar, 215.8g of terrestrial soft-shelled turtle, 45.5g of Rhizoma Drynariae, 45.5g of natural copper calcined in vinegar, 45.5g of calcined borax, 45.5g of safflower, 45.5g of myrrh made from vinegar, Rhubarb 45.5g, the preparation method is: take angelica, safflower, add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, and the extraction time is 160min. The supercritical extract is obtained, which is wrapped with cyclodextrin and used for later use; In the percolation method under the item of extract, 60% ethanol is used as solvent to percolate, and 15 times the amount of percolation solution is collected; ethanol is recovered, concentrated to a relative density of 1.23 at 60°C, ...

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Abstract

The invention provides a tendon-relaxing and pain-easing capsule. The tendon-relaxing and pain-easing capsule is prepared from the following raw materials in weight: 150-400g of Chinese angelica, 100-300g of frankincense processed with vinegar, 100-300g of ground beetles, 10-80g of rhzizoma drynariae, 10-80g of vinegar calcined native copper, 10-80g of calcined borax, 10-80g of safflower, 10-80g of myrrh processed with vinegar and 10-80g of Chinese rhubarb. The invention also discloses a preparation method of the tendon-relaxing and pain-easing capsule. The invention also finds that the tendon-relaxing and pain-easing capsule can increase content of ferulic acid and has the effect obviously better than that of a control group during treatment on rheumatic arthritis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a Shujin Dingtong capsule and a preparation method and application thereof. Background technique [0002] Rheumatoid arthritis is a common autoimmune disease, which can cause joint swelling, deformity, and different degrees of disability, which affects the quality of life of patients. With the in-depth study of the pathogenesis, more and more drugs for the treatment of rheumatoid arthritis have appeared. According to the time and principle of development, they are divided into five generations. The first generation is non-steroidal anti-inflammatory drugs; the second generation is non-steroidal anti-inflammatory drugs; The third generation is glucocorticoids; the third generation is disease-modifying drugs (slow-acting antirheumatic drugs); the fourth generation is early-stage biologics based on alpha tumor necrosis factor (TNF-α) inhibitors; the fifth gener...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/48A61K47/69A61P19/02A61P29/00A61K33/22A61K33/26A61K35/64
CPCA61K9/1652A61K33/22A61K33/26A61K35/63A61K36/126A61K36/232A61K36/286A61K36/324A61K36/328A61K36/708A61K2236/333A61K2236/37A61K2236/51A61K2300/00
Inventor 李洋
Owner NANJING ZHENGKUAN MEDICAL TECH
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