Method for preparing racemized DL-lactic acid with arbitrary concentration by using mixing process

A racemic and mixing technology, applied in organic chemistry, organic chemistry, etc., can solve the problem of inability to guarantee the inherent quality of DL-lactic acid products, and achieve controllable key quality indicators, high equipment utilization, thermal stability. Good results

Active Publication Date: 2017-12-22
湖北壮美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because if D-lactic acid and L-lactic acid are simply mixed according to the weight ratio without other treatment, there is no guarantee that the mixed DL-lactic acid product will be the same or similar to the "racemic mixed DL-lactic acid" produced by the above two methods intrinsic quality of

Method used

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  • Method for preparing racemized DL-lactic acid with arbitrary concentration by using mixing process
  • Method for preparing racemized DL-lactic acid with arbitrary concentration by using mixing process
  • Method for preparing racemized DL-lactic acid with arbitrary concentration by using mixing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Preparation of dilute DL-lactic acid

[0029] A. After the cleaning of the system equipment is completed, 1000Kg of L-lactic acid (L-lactic acid accounting for 98.64%, D-lactic acid accounting for 1.36%, optical rotation -14, total lactic acid content 90.27%) that has been evaluated (accepted) is input into the reaction once. In the tank, add 1600kg of distilled water to dilute under agitation so that the lactic acid content is controlled between 32-38%. Start the heating device of the reaction kettle, increase the temperature to 55.5°C under continuous stirring, put in 3kg 767 injection activated carbon, and continue stirring for 30 minutes. Put the material liquid into the transfer tank at one time and keep it warm for 3 hours. During this period, take samples and filter to determine the specific optical rotation at any time. When the optical rotation is -3.5, the material liquid in the transfer tank is filtered by a candle filter and then input and leveled at one tim...

Embodiment 2

[0051] 1. Preparation of dilute DL-lactic acid. The method is the same as in Example 1.

[0052] 2. Preparation of concentrated DL-lactic acid

[0053] (1) After driving 5500 kg of diluted DL-lactic acid into the reaction tank at one time, turn on the stirring device of the reaction tank.

[0054] (2) Check the vacuum system matching the reaction tank, open the spiral wound tube condenser cooling water valve, start the water circulation vacuum pump, and turn on the reaction tank heating device until the system pressure drops to 2700~2000Pa.

[0055] (3) When the system pressure reaches 2400~2200Pa and the temperature of the materials in the reaction tank rises to 85~90℃ (corresponding to the target content according to experience), stop heating, remove and stop vacuum.

[0056] (4) Add 3 kg of activated carbon for injection of 767 and stir for 5-10 minutes.

[0057] (5) Put the material liquid into the transfer tank at one time, and keep the material liquid at 50~80℃ for 15 minutes.

[0...

Embodiment 3

[0064] 1. Preparation of dilute DL-lactic acid. The method is the same as in Example 1.

[0065] 2. Refining of dilute DL-lactic acid

[0066] (1) After driving 5000 kg of diluted DL-lactic acid into the reaction tank at one time, turn on the stirring device of the reaction tank.

[0067] (2) Check the vacuum system matching the reaction tank, open the spiral wound tube condenser cooling water valve, start the water circulation vacuum pump, and turn on the reaction tank heating device until the system pressure drops to 2700~2000Pa.

[0068] (3) When the system pressure is 2400~2200Pa and the temperature of the materials in the reaction tank rises to 85~90℃ (corresponding to the target content), stop heating, remove and stop vacuum.

[0069] (4) Add 3kg of activated carbon for injection of 767 and stir for 5-10 minutes.

[0070] (5) Put the material liquid into the transfer tank at one time, and keep the material liquid at 50~80℃ for 15 minutes.

[0071] (6) The material enters the leveli...

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Abstract

The invention discloses a method for preparing racemized DL-lactic acid with an arbitrary concentration by using a mixing process. The method comprises the following steps: firstly carrying out a series of pretreatment such as dilution, hydrolysis and detection of D-lactic acid and L-lactic acid which are used as raw materials in a content of 80-100%, then mixing the raw materials, sampling, measuring, correspondingly adjusting, then concentrating the raw materials to a target content, and obtaining thermally stable refined DL-lactic acid products with fewer non-lactic acid impurities, higher whole quality and arbitrary concentration. The method overcomes the defect of quality of the DL-lactic acid products which are obtained by only mixing D-lactic acid and L-lactic acid according to a weight ratio without other corresponding treatment, has the advantages of simple process and high equipment utilization rate; the quality of the products is higher than that of the products of the same industry in China and is equivalent to that of imported products.

Description

Technical field [0001] The invention relates to the technical field of chemical engineering and technology, in particular to a method for preparing racemic DL-lactic acid of any concentration by using a mixing method. Background technique [0002] The chemical name of lactic acid is 2-hydroxypropionic acid (also known as α-hydroxypropionic acid), molecular formula C 3 H 6 O 3 , The relative molecular mass is 90.08. Lactic acid is the smallest chiral molecule in nature. Because the alpha carbon atom in the molecule is an asymmetric carbon atom, it has two configurations of L and D. There are left-handed L-lactic acid, right-handed D-lactic acid and exogenous Rotary DL-lactic acid (in theory, it should be in the free state of the molecule, a mixture of D and L in equal proportions). [0003] However, ordinary lactic acid products are not a single pure substance. In addition to water, in the lactic acid product system, lactoyl lactic acid, polylactyl lactic acid, lactide and lactic a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07B55/00C07C59/08
CPCC07B55/00C07C59/08
Inventor 郑修萍汪芳芳付振宇陈传武丁广建
Owner 湖北壮美生物科技有限公司
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