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Radix cynanchi paniculati paeonol with anti-bacterial and anti-inflammation activity as well as preparation method and application

A technology of Xu Changqing and paeonol, which is applied in the field of Xu Changqing paeonol and its preparation, can solve the problems of Xu Changqing's residue extraction method or patent application not being retrieved, and achieve the reduction of capillary permeability, anti-inflammatory effect, and good antibacterial The effect of action

Inactive Publication Date: 2017-12-22
FOSHAN SANSHUI DISTRICT JIAHUA CHEM RES INST GENERAL PARTNERSHIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the research on Xu Changqing mainly focuses on the efficacy of the ingredients, and there is no corresponding record on the extraction method or patent application of Xu Changqing residue

Method used

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  • Radix cynanchi paniculati paeonol with anti-bacterial and anti-inflammation activity as well as preparation method and application
  • Radix cynanchi paniculati paeonol with anti-bacterial and anti-inflammation activity as well as preparation method and application
  • Radix cynanchi paniculati paeonol with anti-bacterial and anti-inflammation activity as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of Xuchangqing paeonol with antibacterial and anti-inflammatory activity, comprising the following steps:

[0025] 1) Put the remaining Xu Changqing residue after water extraction, dry in an oven at 45°C, and pulverize to obtain Xu Changqing residue powder passed through a 60-mesh sieve;

[0026] 2) After high-temperature sterilization of Xu Changqing residue powder passed through a 60-mesh sieve, add Aspergillus niger suspension, and ferment at 30°C for 5 days;

[0027] 3) Add the fermented Xu Changqing residue powder into 70% ethanol solution according to the ratio of material to liquid 1:25, let it stand for 10 hours, ultrasonically treat it for 30 minutes, and centrifuge at 10000r / min to obtain a supernatant, repeat twice, and combine the supernatants liquid; after removing the solid matter, the solvent was recovered under reduced pressure to obtain Paeonol Xu Changqing.

Embodiment 2

[0029] A preparation method of Xuchangqing paeonol with antibacterial and anti-inflammatory activity, comprising the following steps:

[0030] 1) Put the remaining Xu Changqing residue after water extraction, dry in an oven at 45°C, and pulverize to obtain Xu Changqing residue powder through a 50-mesh sieve;

[0031] 2) After high-temperature sterilization of Xu Changqing residue powder passed through a 50-mesh sieve, add Aspergillus niger suspension, and ferment at 30°C for 5 days;

[0032] 3) Add the fermented Xu Changqing residue powder into 60% ethanol solution according to the ratio of material to liquid 1:30, let it stand for 10 hours, ultrasonically treat it for 30 minutes, and centrifuge at 10000r / min to obtain the supernatant, repeat twice, and combine the supernatants liquid; after removing the solid matter, the solvent was recovered under reduced pressure to obtain Paeonol Xu Changqing.

Embodiment 3

[0034] A preparation method of Xuchangqing paeonol with antibacterial and anti-inflammatory activity, comprising the following steps: 1) placing the remaining Xuchangqing residue after water extraction, drying in an oven at 45°C, pulverizing, and obtaining Xuchangqing residue powder through a 70-mesh sieve ;

[0035] 2) After high-temperature sterilization of Xu Changqing residue powder passed through a 70-mesh sieve, add Aspergillus niger suspension, and ferment at 30°C for 5 days;

[0036] 3) Add the fermented Xu Changqing residue powder into 80% ethanol solution according to the ratio of material to liquid 15:30, let it stand for 10 hours, ultrasonically treat it for 30 minutes, and centrifuge at 10000r / min to obtain a supernatant, repeat twice, and combine the supernatants liquid; after removing the solid matter, the solvent was recovered under reduced pressure to obtain Paeonol Xu Changqing.

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Abstract

The invention discloses radix cynanchi paniculati paeonol with anti-bacterial and anti-inflammation activity as well as a preparation method and an application of radix cynanchi paniculati paeonol. The preparation method comprises steps as follows: 1), radix cynanchi paniculati residues are put in a drying oven at 45 DEG C, dried and smashed, and radix cynanchi paniculati residue powder is obtained; 2), the radix cynanchi paniculati residue powder is added to an aspergillus niger suspension after high-temperature sterilization and is fermented for 5 d at 30 DEG C; 3), the fermented radix cynanchi paniculati residue powder is added to an organic solvent to be left to stand for 10 h, the solvent is recovered under reduced pressure after solid substances are removed, and radix cynanchi paniculati paeonol is obtained. Radix cynanchi paniculati paeonol has an inhibition effect on both bacteria and fungi and can control the oxidative balance environment of skin cells, so that bacteriostatic and ant-inflammation effects are achieved.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to Xuchangqing paeonol with antibacterial and anti-inflammatory activities, its preparation method and application. Background technique [0002] Xu Changqing, a perennial herbaceous plant belonging to the genus Evelophora of the Radixaceae family. It is a commonly used medicine in traditional Chinese medicine. The whole herb of this product is used as medicine, warm in nature, pungent in taste, has the effects of promoting qi and relieving pain, dispelling rheumatism, and relieving numbness and pain. [0003] Early studies found that paeonol had a significant inhibitory effect on Escherichia coli and Bacillus subtilis at a concentration of 1:15000 in vitro, and had a significant inhibitory effect on Staphylococcus aureus at a concentration of 1:2000 in vitro, and it was effective against influenza virus and common pathogenic skin infections. Fungi are also inhibited. Gao Jian et al. prov...

Claims

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Application Information

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IPC IPC(8): C12P7/26C07C45/78C07C49/84A61K8/35A61Q17/00A61Q19/00A61Q19/10A61P17/00A61P31/04A61P31/10A61P31/02A61P29/00C12R1/685
Inventor 不公告发明人
Owner FOSHAN SANSHUI DISTRICT JIAHUA CHEM RES INST GENERAL PARTNERSHIP
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