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HPLC determination method for povidone content in povidone iodine aqueous solution

A povidone-iodine and determination method technology, which is applied in the field of analytical chemistry, can solve problems such as instability of solutions, different degrees of complexation, and easy photolysis, so as to improve quality control and drug safety, and the determination method is simple and sensitive. high effect

Inactive Publication Date: 2017-12-22
FUDAN UNIV
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Problems solved by technology

However, in the current practice, there are such as, the content of povidone in the povidone-iodine liquid preparation is different, and the degree of complexation with iodine is different, resulting in many solutions being unstable and prone to photolysis.
Therefore, the determination of povidone-iodine content in povidone-iodine solution is particularly important for the quality control and drug safety of povidone-iodine preparations, and povidone is an important pharmaceutical excipient in the world, so far There is no report on the determination method

Method used

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  • HPLC determination method for povidone content in povidone iodine aqueous solution
  • HPLC determination method for povidone content in povidone iodine aqueous solution
  • HPLC determination method for povidone content in povidone iodine aqueous solution

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Embodiment 1

[0023] 1. Instruments and reagents

[0024] 1.1 Instrument

[0025] Shimadzu LC-10AD high performance liquid chromatograph, including LC-10AD quaternary pump, SPD-A ultraviolet detector, STO-10A column thermostat, manual injector with 20 μ L quantitative loop (Shimadzu Corporation of Japan); HS2000 Chromatography data workstation (Hangzhou Yingpu Technology Development Co., Ltd.);

[0026] 1.2 Reagent

[0027] Povidone reference substance (RE-GOLD CHEMICAL CO.LTD, purity 99.8% (calculated as dry product), batch number: 03700184807); povidone-iodine aqueous solution (made in the laboratory); acetonitrile (HPLC pure, J&KCHEMICA, batch number: LP50K04 ); deionized water (made by Millipore Direct-Q pure water generator);

[0028] 2. Method

[0029] 2.1 Preparation of solution

[0030] Preparation of Povidone Reference Substance Solution: Take about 0.01g of Povidone Reference Substance, accurately weighed, put in a 10mL volumetric flask, add water to dissolve, set the volume ...

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Abstract

The invention belongs to the field of analytical chemistry, and relates to a method for determining the povidone content in a povidone iodine solution, particularly to an HPLC determination method for the povidone content in a povidone iodine aqueous solution. According to the HPLC determination method, a C18 chromatographic column is used, acetonitrile-water 5:95 is used as a mobile phase, and the povidone content in a povidone iodine aqueous solution is determined at a flow rate of 0.8 mL / min at an ultraviolet detection wave length of 205 nm through an ultraviolet detector. According to the present invention, the analysis determination results of the detected sample show that the HPLC determination method has advantages of convenience, rapidness, good accuracy and high sensitivity, is particularly suitable for the determination of the povidone content in the povidone iodine aqueous solution, and can improve the quality control and the medication safety of the povidone iodine liquid preparation.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and relates to a method for determining the content of povidone in a povidone-iodine solution, in particular to an HPLC method for determining the content of povidone in an aqueous solution of povidone-iodine. Background technique [0002] The prior art discloses that povidone-iodine (PVP-I) is a compound of 1-vinyl-2-pyrrolidone polymer and iodine, and has been made into various dosage forms such as ointment, gel, suppository and liquid preparation , Widely used in disinfection and infection of skin and mucous membranes. Application practice shows that povidone-iodine solution, as a disinfectant, can slowly release iodine to exert antibacterial effect, and has the advantages of less tissue irritation, relatively stable performance, and less toxicity. In 2014, the Ministry of Agriculture of the People's Republic of China officially approved povidone-iodine oral liquid to be launched as a new ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/027G01N2030/8809
Inventor 段更利郁颖佳江洁冰赵美艳朱嘉俊龙佳坤凌今
Owner FUDAN UNIV
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