Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Microspheres for composite heparin anticoagulation coating, preparation method and application

A technology of heparin and microspheres, which is applied in anticoagulation treatment, types of packaging items, special packaging items, etc., can solve problems such as differences in the performance of heparin coating materials, enhance anticoagulant function, reduce thrombosis, and improve the use of effect of life

Inactive Publication Date: 2017-12-29
WUHAN YONGSEN BIOTECH
View PDF11 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing commonly used anticoagulant coatings are heparin coatings, the coating methods are different, and the properties of the heparin coating materials prepared by different methods are also different.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microspheres for composite heparin anticoagulation coating, preparation method and application
  • Microspheres for composite heparin anticoagulation coating, preparation method and application
  • Microspheres for composite heparin anticoagulation coating, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Composite heparin anticoagulant coating microspheres

[0027] The invention discloses a composite heparin anticoagulant coating microsphere, which is a PLA-PEG-PLA heparin microsphere, which uses PLA-PEG-PLA as a carrier and cross-linked hydrazinocurcumin-heparin as the content.

[0028] The preparation method of the composite heparin anticoagulant coating microspheres, the steps are as follows:

[0029] 1) hydrazine curcumin is dissolved in the ethanol solution, is configured into the curcumin alcohol solution that concentration is 5mg / mL, adds MES buffer solution to the curcumin alcohol solution to reduce the curcumin concentration to 2.5mg / mL, then add to the curcumin alcohol solution Add 10g heparin to 300mL curcumin alcohol solution, then add 4g EDC and 4g NHS, stir for 1~2h, make the amino group in hydrazine curcumin fully react with heparin, put the reaction completed solution into the dialysis bag for dialysis for 24~72h After the dialysis is complete...

Embodiment 2

[0031] Embodiment 2 silk fibroin composite heparin microsphere anticoagulant coating

[0032] The preparation method of artificial blood vessel with silk fibroin composite heparin microsphere anticoagulant coating, the steps are as follows:

[0033] 1) Preparation method of silk fibroin: put 20-30g raw silk into 10-12L containing Na 2 CO 3 (2.12g / L) solution in boiling water for 20-30mins, then repeatedly rinse the boiled degummed silk with deionized water to remove residual sericin. Lay the washed silk protein fibers flat in a ventilated place to dry. Weigh 15-25g of dry silk fiber and dissolve it in 100-150mL LiBr solution (9.3M) at 60°C. After the dissolution is completed, use a dialysis bag to attack the silk protein solution for 36-72 hours. After the dialysis is completed, the solution is removed by centrifugation. Impurities are removed to obtain a silk fibroin macromolecular solution.

[0034] 2) The composite heparin anticoagulant coating microspheres prepared in ...

Embodiment 3

[0037] Example 3 Silk fibroin composite heparin microsphere anticoagulant coating

[0038] This example is basically the same as Example 2, except that the concentration of microspheres for heparin-combined anticoagulant coating in the silk fibroin-combined heparin microsphere anticoagulant coating solution is 0.7%wt, and the silk fibroin concentration is 5.6%wt.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses microspheres for a composite heparin anticoagulation coating, a preparation method and an application. A composite heparin anticoagulation coating liquid prepared from the microspheres for the coating has the functions of resisting tissue hyperplasia, resisting inflammatory reactions and the like and is crucial for implantable devices such as artificial blood vessels, intravascular stents, vascular patches and the like to reduce formation of thrombus in human bodies, reduce postoperative complications and prolong the service life of the product.

Description

technical field [0001] The invention relates to a microsphere for composite heparin anticoagulation coating, a preparation method and application thereof, and belongs to the technical field of biomedical materials. Background technique [0002] With the improvement of people's living standards, cardiovascular diseases such as atherosclerosis, vascular embolism and aneurysm pose a great threat to human health. When the human body's own blood vessels cannot supply blood normally due to the above-mentioned diseases and other reasons, it is necessary to use artificial blood vessels for surgical replacement. The caliber of blood vessels in the human body ranges from 2mm to 30mm. Among them, small caliber (diameter < 6mm) is prone to intimal hyperplasia and thrombosis, which leads to low long-term patency rate of small caliber vessels. At present, most of the artificial blood vessel materials used in hospital operations are ePTFE, PU and other materials, but these materials th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/12A61L33/10A61L33/04A61L33/06A61L33/00
CPCA61L33/128A61L33/0005A61L33/0011A61L33/0041A61L33/04A61L33/068A61L33/08A61L2300/216A61L2300/236A61L2300/252A61L2300/42A61L2300/602C08L89/00C08L5/10C08L71/02
Inventor 严拓欧阳晨曦刘雅文刘思诗刘园
Owner WUHAN YONGSEN BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com