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Method for doping of metal ions in hydroxyapatite nano crystal

A technology of hydroxyapatite and metal ions, which is applied in the direction of nanotechnology, nanotechnology, non-metallic elements, etc., can solve the problems of hydroxyapatite nanocrystal morphology and size change, difficulty in achieving high efficiency and controllability, etc., and achieve the goal of doping The effect of impurity increase

Active Publication Date: 2018-01-16
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, there are still many challenges in the effective and controllable doping of hydroxyapatite nanocrystals, for example, when the doped metal ion has hydrolytic properties, or when the radius of the doped metal ion is quite different, It is often difficult to achieve efficient and controllable doping, resulting in changes in the morphology and size of hydroxyapatite nanocrystals, or the formation of impurity phases

Method used

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  • Method for doping of metal ions in hydroxyapatite nano crystal
  • Method for doping of metal ions in hydroxyapatite nano crystal
  • Method for doping of metal ions in hydroxyapatite nano crystal

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Mix 4ml of oleic acid, 16ml of ethanol and 1ml of oleylamine in a 50ml reaction kettle, then add 7ml of 0.25M calcium nitrate to generate calcium oleate precursor, stir for about 5min, add 7ml of 0.15M sodium phosphate, continue stirring for 5min, then Put it into an oven at 150° C. to react for 10 hours, and the resultant is centrifuged and washed three times with cyclohexane and ethanol to obtain rod-shaped hydroxyapatite nanocrystals. The doped metal precursor takes iron oleate as an example, the preparation method is as follows, 1.08g FeCl 3 Dissolve in 3ml of water, then dissolve 3.65g of sodium oleate in the mixture of 8ml of ethanol and 3ml of water, then add 14ml of hexane to the solution for extraction, react dark red ferric oleate at 70°C for 4h, and use Wash twice with water, and then dry at 70°C for 24 hours to obtain reddish-brown waxy iron oleate. The 500mg of hydroxyapatite nanocrystals synthesized above were mixed with 5g of ferric oleate and 5ml of oct...

Embodiment 2

[0026] Mix 500mg of hydroxyapatite nanocrystals with 10g of ferric oleate and 5ml of octadecene in Example 1 in a 50ml three-necked flask, and heat the mixture to 200°C under stirring at a heating rate of 3°C / min And keep it warm for 1 hour, the mixture is separated and purified with the method of Example 1 to obtain hydroxyapatite nanocrystals with an iron ion doping amount of about 13.5%.

Embodiment 3

[0028] Mix 500mg of hydroxyapatite nanocrystals with 5g of iron oleate and 5ml of octadecene in Example 1 in a 50ml three-necked flask, and heat the mixture to 150°C under stirring at a heating rate of 3°C / min And keep it warm for 1 hour, the mixture is separated and purified by the same method as in Example 1, and hydroxyapatite nanocrystals with iron ion doping amount of about 5.1% are obtained.

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Abstract

The invention discloses a method for controllable doping of metal ions in a hydroxyapatite nano crystal. The method comprises the following steps: adding the to-be-doped hydroxyapatite nano crystal and a doped metal ion precursor into an anhydrous organic solvent according to a certain proportion, reacting for a period of time at a certain temperature, generating ion exchange with calcium ions inthe hydroxyapatite nano crystal through doping the metal ions and dispersing towards the inside of the hydroxyapatite nano crystal to obtain the metal ion-doped hydroxyapatite nano crystal. The dopingconcentration can be regulated and controlled through temperature, reactant concentration and reaction time. The method disclosed by the invention can realize single doping and co-doping of a varietyof metal ions in the hydroxyapatite nano crystal and is wider in application prospect.

Description

technical field [0001] The invention relates to a post-doping method under the condition of anhydrous solvent, and belongs to the field of ion doping methods of hydroxyapatite nanocrystals. Through the doping method, one or more metal ion-doped hydroxyapatite nanocrystals can be obtained, and the doping concentration can be adjusted. technical background [0002] Doping nanomaterials is an effective and commonly used strategy to design and optimize their properties and functions. Hydroxyapatite (HAp) is a common alkaline phosphate, which is a natural mineralization of calcium apatite, and its molecular formula is Ca 5 (PO 4 ) 3 (OH), often written as Ca 10 (PO 4 ) 6 (OH) 2 form to highlight its crystal structure. In terms of spatial structure, the most common is the hexagonal system (P63 / m space group, unit cell constant ), the Ca in this structure 2+ Distributed in by PO 4 3- In a lattice composed of tetrahedrons. Hydroxyapatite is slightly soluble in water, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y30/00B82Y40/00
Inventor 徐翔星惠俊峰陈高宇范代娣
Owner NANJING NORMAL UNIVERSITY