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Medical polyurethane foam dressing and preparation method thereof

A technology of polyurethane foam and water-based polyurethane, applied in medical science, bandages, etc., can solve problems such as yellowing and degradation, high toxicity, and poor product appearance, and achieve the effects of simple preparation method, low catalyst toxicity, and good environmental performance

Inactive Publication Date: 2018-01-23
HENAN TUOREN MEDICAL DEVICE GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Polyurethane foam itself is a polymer material. After irradiation sterilization, it is prone to yellowing and degradation behaviors, which will deteriorate the appearance and performance of the product.
[0008] In the prior art, organotin catalysts have high activity and a large adjustable range of foaming time, and are commonly used catalysts in the polyurethane foam industry, but they are highly toxic and cause serious environmental pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A medical polyurethane foam dressing provided by the invention is composed of the following components in mass percentage: 55% to 70% of waterborne polyurethane prepolymer, 2% to 3.5% of catalyst, 6% to 10% of surfactant, cross-linking 0.5% to 5% of sodium alginate, 2% to 10% of sodium alginate, 2% to 10% of sodium carboxymethyl cellulose, 0.3% to 2.5% of anti-yellowing agent, and the balance of purified water; the water-based polyurethane prepolymer It is at least one of polyester type and polyether type, and the catalyst is triethylenediamine, bis(dimethylaminoethyl)ether, 4,4'-(1,2-ethylidene)bis At least one of morpholine, 2,2-dimorpholino diethyl ether, triethanolamine, sodium bicarbonate, the surfactant is L-64, L-62, P188, PEG2000, PEG4000 At least one, the cross-linking agent is a compound with two or more hydroxyl groups, such as at least one of glycerol, sorbitol, trimethylolpropane, and the anti-yellowing agent is β-( 3,5-di-tert-butyl-4-hydroxyphenyl) octad...

Embodiment 2

[0031] A medical polyurethane foam dressing provided by the invention is composed of the following components in mass percentage: 70% of water-based polyurethane prepolymer, 3% of catalyst, 9% of surfactant, 3% of crosslinking agent, and 8% of sodium alginate , sodium carboxymethylcellulose 2%, anti-yellowing agent 0.8%, the balance of purified water; the catalyst is 2,2-dimorpholino diethyl ether: 4,4'-(1,2-ethyl Subunit) bismorpholine=9:1, the surfactant is P188, the crosslinking agent is glycerol, and the water-based polyurethane is polyether type.

[0032] The preparation method of described medical polyurethane foam dressing, it may further comprise the steps:

[0033] (1) Accurately weigh the catalyst, surfactant, crosslinking agent, sodium carboxymethyl cellulose and purified water according to the formula, stir at room temperature at a speed of 350r / min for 1h, and prepare the mixed material A. Put material A into an oven, and control the material temperature to 25°C....

Embodiment 3

[0037] A medical polyurethane foam dressing provided by the invention is composed of the following components by mass percentage: 60% water-based polyurethane prepolymer, 2.5% catalyst, 6% surfactant, 3% crosslinking agent, and 5% sodium alginate , sodium carboxymethyl cellulose 5%, anti-yellowing agent 0.5%, purified water surplus; the catalyst is triethanolamine, the surfactant is PEG2000, the cross-linking agent is sorbitol, the The water-based polyurethane is polyether type.

[0038] The preparation method of this embodiment is the same as that of embodiment 2.

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PUM

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Abstract

The invention provides a medical polyurethane foam dressing. The medical polyurethane foam dressing is prepared from the following components in percentage by mass: 55 to 70 percent of waterborne polyurethane prepolymer, 2 to 3.5 percent of a catalyst, 6 to 10 percent of a surfactant, 0.5 to 5 percent of a crosslinking agent, 2 to 10 percent of sodium alginate, 2 to 10 percent of sodium carboxymethylcellulose, 0.3 to 2.5 percent of an anti-yellowing agent and the balance of purified water. The formula raw materials of the medical polyurethane foam dressing, disclosed by the invention, does notcontain organotin, the toxicity of the catalyst is lower, the content of the organotin does not need to be detected when quality control is performed and the environmental protection performance is better; in addition, the Yi value is determined by using a spectrophotometer, and the difference value of Yi measured before and after irradiation is smaller than 1.5, which shows that almost no yellowing behavior is caused. The preparation method has the advantages of simplicity and no stimulation to skin; besides, the foam cytotoxicity is detected to be a first level by referring to GBT 16886.5 and the requirements are met.

Description

technical field [0001] The invention belongs to the technical field of medical material preparation, and in particular relates to a medical polyurethane foam dressing and a preparation method thereof. Background technique [0002] The skin is the tissue covering the muscles on the surface of the body and is the largest organ of the human body. The skin covers the whole body, and it protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microorganisms. Common skin injuries include burns, wounds, sunburn, frostbite, bed sores, etc. When the skin is damaged by these injuries, the patient will suffer until the skin heals. [0003] Traditional dressings such as gauze and cotton are easy to breed bacteria, and wound exudate can easily form scabs with dry dermal tissue, which hinders epithelialization; at the same time, the wound is easy to adhere to the dressing, causing pain when the dressing is removed, resulting in secondary trauma. ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
Inventor 李阳刘晓飞刘含锐李延鑫王国锋丁雪佳
Owner HENAN TUOREN MEDICAL DEVICE GRP
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