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Surface adsorption antibacterial glycopolymer and preparation method thereof

A surface adsorption and polymer technology, applied in the field of surface adsorption antibacterial sugar-containing polymers and their production, can solve problems such as environmental and biological damage, discomfort for clinical application, etc., achieve good surface modification universality, save production costs, promote The effect of promotion

Inactive Publication Date: 2018-02-02
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods use a large amount of organic solvents or toxic reducing agents, which will cause harm to the environment and organisms, and are not suitable for further clinical applications.

Method used

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  • Surface adsorption antibacterial glycopolymer and preparation method thereof
  • Surface adsorption antibacterial glycopolymer and preparation method thereof
  • Surface adsorption antibacterial glycopolymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 0.15 g of 2-(methacrylamido) glucopyranose, 27 mg of dopamine methacrylamide, 11 mL of methacrylic acid and 1.2 mg of 4-cyano-4-(phenylthioformylthio Base) valeric acid was dissolved in 1mL of dimethyl sulfoxide, under the anaerobic conditions at room temperature of 25 ℃, irradiated under sunlight or simulated sunlight for 40h in one pot, and then methanol was used as a precipitating agent, and the product was slowly Add dropwise to 200mL precipitant methanol to make it coagulate, obtain white precipitate, centrifuge, dry and weigh.

[0035] The structural formula of the obtained antibacterial sugar-containing polymer PDMAG with surface adsorption is as follows:

[0036]

[0037] Where m:n:q=1:1:5, the molecular weight is 24700, see figure 1 , figure 1 It is the GPC measurement curve chart of the antibacterial sugar-containing polymer with surface adsorption of Example 1 of the present invention. Such as figure 1 As shown, the molecular weight distribution ...

Embodiment 2

[0043] Weigh 0.15 g of 2-(methacrylamido)glucopyranose-mannose, 27 mg of dopamine methacrylamide, 4.7 mg of 4-cyano-4-(phenylthioformylthio) in 11 μL of methacrylic acid ) valeric acid was dissolved in 1mL of dimethyl sulfoxide, under the anaerobic condition at room temperature of 25 ℃, irradiated under sunlight or simulated sunlight for 40h in one pot, and then methanol was used as a precipitant, and the product was slowly dropped Add 200mL precipitating agent methanol to make it coagulate, obtain white precipitate, centrifuge, dry and weigh.

[0044] Mix 50mL, 0.1mol / L tris solution with 22.9mL, 0.1mol / L hydrochloric acid, dilute to 100mL with water, adjust the pH of the mixture to 8.2, and prepare Tris-HCl solution.

[0045] Take 0.1g of the surface-adsorbed antibacterial sugar-containing polymer PDMAG and dissolve it in 5mL of the prepared Tris-Hcl solution to form a mixed solution. Put the PDMS in a petri dish, add the mixed solution dropwise to the substrate, immerse it,...

experiment example 3

[0048] Weigh 0.15 g of 2-(methacrylamido)glucopyranose, 27 mg of dopamine methacrylamide, 11 μL of methacrylic acid and 0.8 mg of isobutyronitrile dithionaphthoate and dissolve in 1 mL of dimethyl In sulfoxide, under the anaerobic condition at room temperature at 25°C, irradiate one-pot reaction under sunlight or simulated sunlight for 40 hours, then use methanol as a precipitant, slowly drop the product into 200mL precipitant methanol to make it coagulate , a white precipitate was obtained, centrifuged, dried, and weighed.

[0049] Mix 50mL, 0.1mol / L tris solution with 22.9mL, 0.1mol / L hydrochloric acid, dilute to 100mL with water, adjust the pH of the mixture to 8.2, and prepare Tris-HCl solution.

[0050] Take 0.1g of surface-adsorbed antibacterial sugar-containing polymer dissolved in 5mL of the prepared Tris-Hcl solution to form a mixed solution, place the stainless steel sheet in a petri dish, add the mixed solution onto the substrate, immerse, and place it in a cool pla...

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Abstract

The invention discloses a surface adsorption antibacterial glycopolymer and a preparation method thereof. A chain transfer agent is added into raw materials including methacrylamide sugar-containing monomers, carboxylic acid monomers and dopamine monomers to prepare the glycopolymer under solar light or simulated solar light with similar wavebands according to a one-step method. The glycopolymer is high in water solubility, great in surface adsorption performance, available for surface in-situ reduction of silver ions and applicable to preparation of functional antibacterial glycopolymer materials and later-stage surface antibacterial treatment of inorganic, organic and metal materials and the like. The dopamine monomers have catechol functional groups, and the glycopolymer forms covalentbonds or strong non-covalent bonds along with material surfaces through the catechol functional groups to be adsorbed on the material surfaces; carboxylic acid is chelated with silver ions to fix thesilver ions on a substrate; the sugar-containing monomers and the dopamine monomers have reducibility and capable of realizing in-situ reduction of the silver ions to achieve an antibacterial effect.

Description

technical field [0001] The invention specifically relates to a surface-adsorbed antibacterial sugar-containing polymer and a preparation method thereof. Background technique [0002] In recent years, due to the extensive use of antibiotics and disinfectants, drug-resistant bacteria have mutated, resulting in outbreaks of pathogenic bacteria and infectious diseases, which has led researchers to actively look for new types of antibacterial materials with high safety, good durability and low toxicity. New antibacterial material. In the current antibacterial strategy, nano-silver and silver ions enter the bacteria through the cell wall of the bacteria to play a bactericidal or antibacterial effect. Therefore, silver-based compounds or silver-loaded nanomaterials have the advantages of broad-spectrum antibacterial, persistence, and safety. At present, the preparation methods of nano-silver are mainly microwave radiation, ultrasonic radiation and microbial reduction. Most of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/58C08F220/06C08F2/48C08F2/38
CPCC08F220/58C08F2/38C08F2/48C08F220/06
Inventor 陈高健彭伦
Owner SUZHOU UNIV
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