Porous polylactic acid material for scaffold for tissue engineering and preparation method thereof

A tissue engineering scaffold and porous material technology, applied in the fields of polymer material processing and biomedicine, can solve problems such as poor biocompatibility and complex process, and achieve good hydrolysis resistance, excellent mechanical properties, and good dimensional stability. Effect

Inactive Publication Date: 2018-02-09
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above disclosed methods for preparing engineering scaffold materials from polylactic acid all have the disadvantage of complex process, and the addition of other fillers makes it less biocompatible as an engineering scaffold.

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  • Porous polylactic acid material for scaffold for tissue engineering and preparation method thereof
  • Porous polylactic acid material for scaffold for tissue engineering and preparation method thereof
  • Porous polylactic acid material for scaffold for tissue engineering and preparation method thereof

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[0033] The invention provides a preparation method of a polylactic acid porous material for a tissue engineering scaffold, the preparation method comprising the following steps:

[0034] 1) Dissolve the dried and weighed L-polylactic acid (PLLA) and D-polylactic acid (PDLA) in the solvent respectively to form the corresponding polylactic acid solution, then mix the L-polylactic acid solution and the D-polylactic acid solution, and then add Adding a porogen into the mixed solution, and then performing solution casting; waiting for the solvent to volatilize to obtain a polylactic acid stereoblend;

[0035] 2) Put the obtained polylactic acid stereoblend into deionized water to leach the porogen, and replace the deionized water every 1 to 24 hours, and the dissolution time is 1 to 14 days;

[0036] 3) Dry the leached sample under the condition of 40-150° C. to obtain a highly heat-resistant polylactic acid porous scaffold material.

[0037]In step 1) of the present invention, th...

Embodiment 1

[0040] Example 1 Preparation of Polylactic Acid Porous Materials for Engineering Supports

[0041] (1) Using the solution casting method, dissolve 3g of dry and weighed polylactic acid (PLLA) and 3g of polylactic acid (PDLA) in 45ml of dichloromethane solvent respectively, stir for 2h, and then mix the polylactic acid solution and D-polylactic acid solution, stirred for 24 hours, added 24g of sodium chloride particles with a size of 100-180 μm, stirred until the viscosity of the solution was large enough, and the sodium chloride particles no longer sank to the bottom, and then the solution was cast; at room temperature Stand for 7 days, and the polylactic acid stereoblend is obtained after the solvent volatilizes;

[0042] (2) The obtained blend is put into deionized water and the sodium chloride is leached, and the deionized water is changed every 12 hours, and the dissolving time is 3 days;

[0043] (3) Dry the leached sample in a vacuum oven at 40° C. to obtain a highly he...

Embodiment 2

[0048] Example 2 Preparation of Polylactic Acid Porous Materials for Engineering Supports

[0049] (1) Using the solution casting method, dissolve 3.6g of dry and weighed L-polylactic acid (PLLA) and 2.4g of D-polylactic acid (PDLA) in 45ml of dichloromethane solvent respectively, stir for 2 hours, and then mix the L-polylactic acid (PDLA) Lactic acid solution and D-polylactic acid solution, stirred for 24 hours, added 24g of sodium chloride particles with a size of 100-180 μm, stirred until the viscosity of the solution was large enough, and the sodium chloride particles no longer sank to the bottom, and then the solution was cast; at room temperature Place under the condition for 7 days, and the polylactic acid stereoblend is obtained after the solvent volatilizes;

[0050] (2) The obtained blend is put into deionized water and the sodium chloride is leached, and the deionized water is changed every 12 hours, and the dissolving time is 3 days;

[0051] (3) Dry the leached s...

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Abstract

The invention belongs to the field of polymer material processing and biomedicine and relates to a porous polylactic acid material for a scaffold for tissue engineering and a preparation method thereof. The preparation method of the porous polylactic acid material for the scaffold for tissue engineering comprises the steps that poly-L-lactic acid, poly-D-lactic acid and a pore-foaming agent are prepared into a polylactic acid steric blend through a solution casting method; the pore-foaming agent in the polylactic acid steric blend is removed, and then the porous polylactic acid material for the scaffold for tissue engineering is obtained through drying. The mass ratio of the poly-L-lactic acid to the poly-D-lactic acid is 1:9 to 9:1, the mass ratio of polylactic acid to the pore-foaming agent is 1:6 to 1:2, and the polylactic acid contains the poly-L-lactic acid and the poly-D-lactic acid. The obtained porous polylactic acid material for the scaffold for tissue engineering has highly controllable pore structure and pore size and very high aperture ratio, the porosity of the scaffold is 70-82%, and energy storage modulus can be up to 630-3327 MPa at the temperature of 37 DEG C. In addition, the porous polylactic acid material has very good biocompatibility.

Description

technical field [0001] The invention belongs to the fields of polymer material processing and biomedicine, and in particular relates to a polylactic acid porous material for tissue engineering scaffolds and a preparation method thereof. Background technique [0002] Tissue engineering has emerged in recent decades following the needs of medical development. The earlier definition of tissue engineering was proposed by Professor Robert Langer in 1993. He defined tissue engineering as: a comprehensive discipline that applies biology and engineering techniques to develop functional substitutes for damaged tissues. This definition is further expanded as: applying engineering and life science principles and techniques to study the basic relationship between normal and pathological mammalian tissue structure and function, and to develop biological substitutes to restore, maintain and improve tissue performance. Key elements in the tissue engineering process include: cells, biologi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/58A61L27/56
CPCA61L27/26A61L27/56A61L27/58A61L2400/08C08L67/04
Inventor 杨伟谢燕王云兵兰小蓉包睿莹雷洋曹志强杨鸣波
Owner SICHUAN UNIV
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