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Nattokinase and melatonin composition capable of improving sleep and preparation method thereof

A technology of nattokinase and melatonin, which is applied in the field of health food, can solve problems such as inattention and improve sleep quality, and achieve the effects of prolonging sleep time, good taste and promoting sleep

Inactive Publication Date: 2018-02-16
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While prolonging the sleep time, these drugs will have different degrees of side effects such as dizziness, fatigue, drowsiness, lack of concentration, and even temporary forgetfulness and hangovers, and they have not really improved sleep quality.

Method used

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  • Nattokinase and melatonin composition capable of improving sleep and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 nattokinase melatonin composition A

[0036] The composition is composed of nattokinase and melatonin, wherein the consumption of nattokinase is calculated by nattokinase fibrinolytic activity, and the fibrinolytic activity of nattokinase in the composition is 500IU / g, and the content of melatonin is 0.1 mg / g.

[0037] The preparation method of this composition is:

[0038] (1) centrifuging the nattokinase fermented liquid at 5000 rpm, concentrating the supernatant by ultrafiltration at room temperature to obtain a nattokinase concentrated solution, and vacuum freeze-drying to obtain a crude nattokinase freeze-dried powder;

[0039] (2) Nattokinase crude freeze-dried powder is mixed with melatonin powder in proportion, and auxiliary materials are added to ensure that the fibrinolytic activity of nattokinase in the composition is 500IU / g, and the content of melatonin is 0.1mg / g. g.

Embodiment 2

[0040] Embodiment 2 nattokinase melatonin composition B

[0041] The composition is composed of nattokinase and melatonin, wherein the consumption of nattokinase is calculated based on the fibrinolytic activity of nattokinase, and the fibrinolytic activity of nattokinase in the composition is 750IU / g, and the content of melatonin is 0.1 mg / g.

[0042] The preparation method of this composition is:

[0043] (1) centrifuging the nattokinase fermented liquid at 8000rpm, concentrating the supernatant by ultrafiltration at room temperature to obtain a nattokinase concentrated solution, and vacuum freeze-drying to obtain a crude nattokinase freeze-dried powder;

[0044] (2) Nattokinase crude freeze-dried powder is mixed with melatonin powder in proportion, and auxiliary materials are added to ensure that the fibrinolytic activity of nattokinase in the composition is 750IU / g, and the content of melatonin is 0.1mg / g. g.

Embodiment 3

[0045] Embodiment 3 nattokinase melatonin composition C

[0046] The composition is composed of nattokinase and melatonin, wherein the consumption of nattokinase is calculated by nattokinase fibrinolytic activity, and the fibrinolytic activity of nattokinase in the composition is 1000IU / g, and the content of melatonin is 0.1mg / g.

[0047] The preparation method of this composition is:

[0048] (1) centrifuging the nattokinase fermented liquid at 10000 rpm, concentrating the supernatant by ultrafiltration at room temperature to obtain a nattokinase concentrated solution, vacuum freeze-drying to obtain a nattokinase lyophilized powder;

[0049] (2) Nattokinase crude freeze-dried powder is mixed with melatonin powder in proportion, and auxiliary materials are added to ensure that the fibrinolytic activity of nattokinase in the composition is 1000IU / g, and the content of melatonin is 0.1mg / g. g.

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Abstract

The invention discloses a nattokinase and melatonin composition capable of improving sleep and a preparation method thereof, and belongs to the field of health foods. The composition is prepared fromnattokinase and melatonin, the fibrinolysis activity of the nattokinase in 1g of composition is 500-1000IU, and the content of the melatonin is 0.1mg / g. The preparation method comprises the steps: (1)preparing nattokinase fermentation liquid by using bacillus subtilis capable of producing a high yield of nattokinase, taking the supernatant liquid after centrifuging and performing ultrafiltrationconcentration, and performing vacuum drying to obtain nattokinase freeze-dried powder; and (2) mixing the nattokinase freeze-dried powder with melatonin powder, and adding auxiliary materials. The nattokinase and melatonin composition takes the nattokinase and the melatonin as raw materials, and the two components play a synergistic effect on sleep. Proven by experiments, the nattokinase and melatonin composition disclosed by the invention can obviously prolong the pentobarbital sodium sleep time and shorten the barbital sodium sleep latency, and has a function of enhancing and improving sleep.

Description

technical field [0001] The invention belongs to the field of health food, and in particular relates to a composition of nattokinase and melatonin and a preparation method thereof. Background technique [0002] Awakening-sleep rhythm is a basic life phenomenon of the human body. Normal people have a rhythmic alternation of waking and sleeping every 24 hours. Sleep is an extremely important physiological function to maintain human life and is closely related to human health. Sleep can be divided into normal phase sleep period (non-rapid eye movement sleep period NREM) and abnormal phase sleep period (rapid eye movement sleep period REM). During the phase sleep period, after maintaining for another 20-30 minutes, it will turn into the normal phase sleep period, and repeat this about 4-6 times every night. The amount of sleep often varies with age. Newborns need 18-20 hours of sleep, children 12-14 hours, adults 7-9 hours, and the elderly generally only need 5-7 hours. Clinic...

Claims

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Application Information

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IPC IPC(8): A23L33/00
CPCA23L33/00A23V2002/00A23V2200/322
Inventor 曾建龚爱华严永敏徐玲王艺凡张露韩秀陈曦唐宇程洁
Owner JIANGSU UNIV
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