Oral preparation containing tebipenem pivoxil and preparation method thereof
A technology for tipipenem ester and oral preparation, applied in the field of pharmaceutical preparations, can solve the problems of unsatisfactory taste masking effect, low drug dissolution rate, complicated preparation process, etc. Simple preparation process
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Embodiment 1
[0048] Example 1 Preparation of oral preparations of tipipenem pectin
[0049] Prescription (specification: 50mg / 0.5g):
[0050]
[0051] Note: 50mg in the specifications is calculated as telipenem, and 50mg telipenem is equivalent to 65mg telipenem ester (the same below).
[0052] Preparation Process:
[0053] ① Weigh the prescription amount of drug and soluble carrier mixture, namely RL PO and RS PO, add an appropriate amount of absolute ethanol (Eudragit mixture: absolute ethanol = 1:10), stir at high speed to completely dissolve the drug and carrier material;
[0054] ② Take the mannitol that has been passed through a 100-mesh sieve in the prescribed amount and add it to the solution in step 1, stir to form a uniform suspension, dry the solvent by rotary evaporation under reduced pressure, dry in vacuum at 40°C for 2 hours, crush and pass through a 80-mesh sieve, and store in a sealed place in the dark for later use ;
[0055] ③ Mix the prepared tipipenem ester s...
Embodiment 2
[0057] Example 2 Preparation of oral preparations of tipipenem pectin
[0058] Prescription (specification: 50mg / 0.5g):
[0059]
[0060] Preparation process: with embodiment 1.
Embodiment 3
[0061] Example 3 Preparation of oral preparations of tipipenem pectin
[0062] Prescription (specification: 50mg / 0.5g):
[0063]
[0064]
[0065] Preparation process: with embodiment 1.
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