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Structure-controllable magnetic response mineralized collagen coating used for surface of medical metal implant and preparation method thereof

A technology of mineralized collagen and implants, applied in coatings, prostheses, electrolytic coatings, etc., to achieve the effect of promoting osteogenic differentiation

Active Publication Date: 2018-02-27
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, magnetic hydrogels are widely used in tissue engineering scaffolds, but few reports have been reported as surface modification.

Method used

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  • Structure-controllable magnetic response mineralized collagen coating used for surface of medical metal implant and preparation method thereof
  • Structure-controllable magnetic response mineralized collagen coating used for surface of medical metal implant and preparation method thereof
  • Structure-controllable magnetic response mineralized collagen coating used for surface of medical metal implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of electrolyte: Ca(NO 3 ) 2 ·6H 2 O dissolved in water and prepared as Ca(NO 3 ) 2 aqueous solution, the NH 4 h 2 PO 4 Dissolved in water, prepared as NH with a phosphorus concentration of 100mM 4 h 2 PO 4 aqueous solution, the Fe 3 o 4 The nanoparticles were formulated into a 0.5mg / mL sol. Dissolve Beiling liquid collagen in 0.005mol / L acetic acid, stir to form a solution with a collagen concentration of 0.5g / L, mix the above four solutions to make Fe 3 o 4 The mass ratio of nanoparticles to collagen was 0.67, and then NH 3 ·H 2 O solution to adjust the pH of the electrolyte to 4.4.

[0026] The titanium plate after surface cleaning is used as the cathode, and the platinum electrode is used as the anode. The distance between the cathode and the anode is 1cm. Take 15mL of the electrolyte and place it in a constant temperature bath at 37°C. The alternating voltage deposition mode is used. The applied voltage in the first stage is - 2.4V, the a...

Embodiment 2

[0028] Preparation of electrolyte: Ca(NO 3 ) 2 ·6H 2 O dissolved in water and prepared as Ca(NO 3 ) 2 aqueous solution, the NH 4 h 2 PO 4 Dissolved in water, prepared as NH with a phosphorus concentration of 100mM 4 h 2 PO 4 aqueous solution, the Fe 3 o 4 The nanoparticles were formulated into a 0.5mg / mL sol. Dissolve Beiling liquid collagen in 0.005mol / L acetic acid, stir to form a solution with a collagen concentration of 0.5g / L, mix the above four solutions to make Fe 3 o 4 The mass ratio of nanoparticles to collagen was 0.5, and then NH 3 ·H 2 O solution to adjust the pH of the electrolyte to 4.3.

[0029]The titanium plate after surface cleaning is used as the cathode, the platinum electrode is used as the anode, and the distance between the cathode and the anode is 1cm. Take 15mL of the electrolyte and place it in a constant temperature bath at 37°C. The alternating voltage deposition mode is used. The applied voltage in the first stage is - 2.4V, the app...

Embodiment 3

[0031] Preparation of electrolyte: Ca(NO 3 ) 2 ·6H 2 O dissolved in water and prepared as Ca(NO 3 ) 2 aqueous solution, the NH 4 h 2 PO 4 Dissolved in water, prepared as NH with a phosphorus concentration of 100mM 4 h 2 PO 4 aqueous solution, the Fe 3 o 4 The nanoparticles were formulated into a 0.5mg / mL sol. Dissolve Beiling liquid collagen in 0.005mol / L acetic acid, stir to form a solution with a collagen concentration of 0.5g / L, mix the above four solutions to make Fe 3 o 4 The mass ratio of nanoparticles to collagen was 0.25, and then NH 3 ·H 2 O solution to adjust the pH value of the electrolyte to 4.2.

[0032] The titanium plate after surface cleaning is used as the cathode, the platinum electrode is used as the anode, and the distance between the cathode and the anode is 1cm. Take 15mL of the electrolyte and place it in a constant temperature bath at 37°C. The magnetic field-assisted alternating voltage deposition mode is used. The first stage is applied...

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Abstract

The invention discloses a structure-controllable magnetic response mineralized collagen coating used for the surface of a medical metal implant. The structure-controllable magnetic response mineralized collagen coating is constituted by mineralized collagen and Fe3O4 nanometer particles, wherein the Fe3O4 nanometer particles are distributed in the mineralized collagen. The structure-controllable magnetic response mineralized collagen coating adopts a magnetic field assisted alternate electric potential method; by adjusting parameters such as magnetic field strength in the composing and depositing process of an electrolyte, the nanometer magnetic particles are compounded into the mineralized collagen; and a modified layer with the magnetic response structure-controllable mineralized collagen is prepared on the surface of the metal implant. According to a preparation method of the structure-controllable magnetic response mineralized collagen coating, the structure-controllable magnetic response mineralized collagen coating is prepared through effective combination of an outer magnetic field and electrochemical deposition, the cell differentiation action is regulated and controlled, and the structure-controllable magnetic response mineralized collagen coating used for the surface of the medical metal implant has application prospects in restoration of hardbone tissue.

Description

technical field [0001] The invention relates to a coating and a preparation method thereof, in particular to a structurally controllable magnetic response mineralized collagen coating used on the surface of a medical metal implant and a preparation method thereof. Background technique [0002] The growth and reconstruction process of natural bone is in a dynamic microenvironment, and bone tissue will be physically stimulated at a certain frequency during daily activities. Therefore, in addition to the need for materials to provide a static biological microenvironment for cell / tissue growth, biological stimulation is also an indispensable and important means of modulation. A large number of studies have proved that appropriate mechanical stimulation plays a very important role in promoting and modulating in the process of osteogenic growth or bone remodeling. Magnetic nanoparticles have been widely used in biomedicine in recent years due to their proven biocompatibility and ...

Claims

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Application Information

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IPC IPC(8): C25D15/00A61L27/30A61L27/34A61L27/50
CPCA61L27/306A61L27/34A61L27/50A61L2430/02C25D15/00C08L89/00
Inventor 翁文剑庄均珺程逵
Owner ZHEJIANG UNIV
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