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Method of preparing hemostatic dressing by using hydrogel

A technology of hemostatic dressing and hydrogel, which is applied in the direction of medical formula, medical science, absorbent pads, etc. It can solve problems such as fracture, poor stress, and failure to meet processing requirements, so as to prevent fracture, increase healing speed, and reduce network and the effect of swelling rate

Inactive Publication Date: 2018-03-06
黄旭东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention: in view of the disadvantage that the current dressing composed of chitosan has poor stress, after contacting blood, it will quickly form a gel and break, and it has a better hemostatic effect on general bleeding. However, it is unable to meet the treatment requirements of a large amount of rapid bleeding, and a method for preparing a hemostatic dressing with hydrogel is provided

Method used

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  • Method of preparing hemostatic dressing by using hydrogel

Examples

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Effect test

Embodiment 1

[0030] The decolorizer is activated carbon.

[0031] The crosslinking agent is dicumyl peroxide.

[0032] The pharmaceutical excipient is sodium alginate.

[0033] A method for preparing a hemostatic dressing with hydrogel, the method comprising the steps of:

[0034] (1) Wash the orange peel with water, then put it into a grinder and grind it to get the grinded product. Put the crushed product and water into a container at a mass ratio of 1:3, heat it to 98°C, keep it for 5 minutes, and filter it to get Filter residue, wash the filter residue with water twice to obtain the washed filter residue, in parts by weight, take 10 parts of water, 7 parts of filter residue, 3 parts of silk, and 0.8 parts of 1.0mol / L sulfurous acid solution in a container for mixing , heated to 90°C, and stirred at 6000~7000r / min for 1h. After cooling down to 40°C, add 1% xylanase of the filtrate quality to the container, keep it for 2min, then raise the temperature to 70°C, and then add to the filtrat...

Embodiment 2

[0040] The decolorizer is activated carbon.

[0041] The cross-linking agent is benzoyl peroxide.

[0042] The pharmaceutical excipient is polyvinylpyrrolidone.

[0043] A method for preparing a hemostatic dressing with hydrogel, the method comprising the steps of:

[0044] (1) Wash the orange peel with water, then put it into a grinder and grind it to get the grinded product. Put the crushed product and water into a container at a mass ratio of 1:4, heat it to 99°C, keep it for 7 minutes, and filter it to get Filter residue, wash the filter residue with water twice to obtain the washed filter residue, in parts by weight, take 13 parts of water, 7 parts of filter residue, 3 parts of silk, and 0.9 part of 1.0mol / L sulfurous acid solution in a container for mixing , heated to 93°C, and stirred at 6500r / min for 1.2h. After cooling down to 45°C, add 1.5% xylanase of the filtrate quality to the container, keep it for 2.5min, then raise the temperature to 75°C, and then add to the...

Embodiment 3

[0050] The bleaching agent is clay.

[0051] The crosslinking agent is dicumyl peroxide.

[0052] The pharmaceutical excipient is polyvinylpyrrolidone.

[0053] A method for preparing a hemostatic dressing with hydrogel, the method comprising the steps of:

[0054] (1) Wash the orange peel with water, then put it into a grinder and grind it to get the grinded product. Put the crushed product and water into a container at a mass ratio of 1:4, heat to 100°C, keep it for 8 minutes, and filter to get Filter residue, wash the filter residue with water 3 times to obtain the washed filter residue, in parts by weight, take 15 parts of water, 8 parts of filter residue, 4 parts of silk, and 1 part of 1.0mol / L sulfurous acid solution in a container for mixing , heated to 95°C, and stirred at 7000r / min for 1.5h. After cooling down to 50°C, add 2% xylanase of the filtrate quality to the container for 3min, then raise the temperature to 80°C, and then add the filtrate to the filtrate 2% ...

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Abstract

The invention relates to the field of medical dressing materials, and particularly relates to a method of preparing a hemostatic dressing by using hydrogel. When in preparation of the hydrogel, orangepeels are boiled to passivate pectinase activity, pectin is extracted through an acid method, methoxyl is removed through strong base so as to form degreased pectin, then amino and carboxyl in adipoyl dihydrazide and the like are used to perform dehydration-condensation reaction so as to form amido bonds to obtain the hydrogel preventing breaking; a cross-linking agent improves the cross-linkingdensity of molecular chains, medicinal auxiliary materials are absorbed by a user so as to add nutrition to tissues of the wound, increase cell activity, provide energy for cell division activity andimprove the healing speed, the anticoagulant property of sodium heparin can prevent the wound from bonding with the hemostatic dressing, preventing flowing blood from solidifying and allowing the blood to be adsorbed at a faster speed, the cross-linking agent, the medicinal auxiliary materials and the sodium heparin are combined to stop excessive bleeding. The hemostatic dressing prepared by the method has good hemostatic performance, can better stop bleeding for a long time, and has high adsorbability, thereby being a safe and efficient hemostatic dressing and being worth promoting and using.

Description

technical field [0001] The invention relates to the field of medical dressing materials, in particular to a method for preparing a hemostatic dressing with hydrogel. Background technique [0002] Clinical medicine points out that if the human body does not take effective first aid measures due to acute bleeding, the patient will die within 6 to 20 minutes. If the blood loss of the human body exceeds 20% of the whole body's blood volume (about 800cc for adults), shock will occur; if the blood loss exceeds 40% of the whole body's blood volume (about 1600cc for adults), it will be on the verge of death. According to statistics, the number of traumatic deaths accounts for 10% of the total number of deaths, and the death caused by massive hemorrhage accounts for 30% to 40% of them. Therefore, early control of hemorrhage is the main method to reduce mortality. [0003] At present, after various arteries and veins are punctured and extubated in a hospital, it is necessary to compr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/40A61L15/28A61L15/46A61L15/64A61L15/44
CPCA61L15/28A61L15/40A61L15/42A61L15/44A61L15/46A61L15/64A61L2300/236A61L2300/30A61L2300/404A61L2300/42A61L2400/04C08L5/06C08L5/08C08L5/10
Inventor 张永华刘蓉凤尹凯欣
Owner 黄旭东
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