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High-strength polylactic acid bone fixation material and preparation method thereof

A polylactic acid bone and fixation material technology, applied in medical science, surgery, etc., can solve the problems of poor viscoelasticity, limited stretching ratio, difficult mechanical strength, etc.

Active Publication Date: 2018-03-09
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large degree of elongation flow and deformation involved in the solid-state thermal drawing process, in order to obtain a high draw ratio, the material should have high viscoelasticity and "strain hardening" elongation flow at the processing temperature. However, the molecular chain of polylactic acid is rigid and the intermolecular entanglement is less, which leads to its poor viscoelasticity at high temperature and the characteristics of "strain softening". Oriented microfibrillation to achieve higher mechanical strength

Method used

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  • High-strength polylactic acid bone fixation material and preparation method thereof
  • High-strength polylactic acid bone fixation material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Put 0.5 parts of 1,6-hexamethylene diisocyanate into the reactor, then slowly add 2 parts of amino-terminated polyoxyethylene ether (molecular weight 2000g / mol) dropwise therein at -5°C, and react for 20 minutes to obtain polyether-isocyanate Multifunctional long-chain flexible branching agent;

[0024] Add 3 parts of long-chain flexible branching agent, 3 parts of 1,4-butanediol diglycidyl ether and 100 parts of dry polylactic acid into the internal mixer, and react at 170°C for 10 minutes to obtain a multi-arm structure Long chain branched polylactic acid biocompatible material;

[0025] Compress the obtained polylactic acid material into a size of 50×50×4mm 3 The sample, pressing temperature: 170°C, pressing pressure 10MPa, then fix the polylactic acid sample on a temperature-controllable and speed-adjustable biaxial stretching device, keep the temperature at 70°C for 20min, and then stretch it along the longitudinal direction and the transverse direction at the sam...

Embodiment 2

[0028] Put 5 parts of 4,4'-dicyclohexylmethane diisocyanate into the reactor, then slowly add 10 parts of amino-terminated polyoxypropylene ether (molecular weight 3000g / mol) dropwise at 20°C, and react for 40 minutes to obtain poly Ether-isocyanate polyfunctional long-chain flexible branching modifier;

[0029] Add 5 parts of long-chain flexible branching agent, 5 parts of glycerol triglycidyl ether and 100 parts of dry polylactic acid into the internal mixer, and react at 200°C for 30 minutes to obtain long-chain branched Polylactic acid biocompatible material;

[0030] Compress the obtained polylactic acid material into a size of 50×50×4mm 3 The sample, pressing temperature: 200°C, pressing pressure 7MPa, then fix the polylactic acid sample on a temperature-controllable and speed-adjustable biaxial stretching device, keep the temperature at 90°C for 40min, and then stretch it along the longitudinal direction and the transverse direction at the same time Perform stretching...

Embodiment 3

[0033] Put 10 parts of isophorone diisocyanate into the reactor, then slowly drop 10 parts of hydroxyl-terminated polyoxypropylene ether (molecular weight 4000g / mol) into it at 30°C, and react for 60 minutes to obtain polyether-isocyanate polyfunctional Long chain flexible branching modifier;

[0034] Add 10 parts of long-chain flexible branching agent, 10 parts of pentaerythritol tetraglycidyl ether and 100 parts of dry polylactic acid into the internal mixer, and react at 220°C for 40 minutes to obtain long-chain branched polylactic acid with multi-arm structure biocompatible materials;

[0035] Compress the obtained polylactic acid material into a size of 50×50×4mm 3 The sample, pressing temperature: 210°C, pressing pressure 15MPa, then fix the polylactic acid sample on a temperature-controllable and speed-adjustable biaxial stretching device, keep the temperature at 100°C for 60min, and then stretch it along the longitudinal direction and the transverse direction at the s...

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Abstract

The invention discloses a high-strength polylactic acid bone fixation material and a preparation method thereof. The high-strength polylactic acid bone fixation material is characterized in that a multifunctional long-chain flexible branching agent is prepared by virtue of reaction of polyether and aliphatic isocyanate and is combined with a multifunctional epoxy compound for use, and long-chain branched polylactic acid is prepared by virtue of a simple, convenient and feasible reactivity processing method, so that the entanglement degree of chains among polylactic acid molecules is increased,and the tensile property of polylactic acid is improved; and by introducing a polyether long chain, polylactic acid is endowed with relatively good impact toughness, and a high-power uniformly-orientated polylactic acid material is prepared on that bases by virtue of a double-shaft solid phase thermal stretching method, so that the mechanical strength of the polylactic acid material as the bone fixation material is substantially enhanced, and meanwhile, the biocompatibility of the polylactic acid material is improved.

Description

1. Technical field [0001] The invention relates to a high-strength polylactic acid bone fixation material and a preparation method thereof, belonging to the technical field of biomedical polymer materials and polymer material processing. 2. Background technology [0002] Polylactic acid is non-toxic, non-irritating, has excellent biocompatibility and complete biodegradability, and is a biodegradable biomaterial approved by the FDA for human use. The development of high-strength absorbable orthopedic fixation materials based on polylactic acid began in the 1970s, and is considered the most promising due to its superior biocompatibility, good biomechanical properties and appropriate degradation speed. The promising biomedical material has irreplaceable advantages in the field of bone repair, such as it can be degraded in the body and excreted with metabolites, thus avoiding secondary surgery. However, the mechanical strength of polylactic acid is not high, and it does not hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/42C08G18/50C08G18/58C08G18/10C08G18/73C08G18/75A61L31/06A61L31/14
CPCA61L31/06A61L31/14C08G18/10C08G18/4045C08G18/4283C08G18/5024C08G18/58C08G18/73C08G18/755C08G18/758C08G18/42C08L75/06C08L75/08
Inventor 赵晓文刘亚龙叶林李正秋
Owner SICHUAN UNIV
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