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Quality control method of medicine with functions of clearing lung, eliminating phlegm and suppressing cough

A technology for clearing the lungs, resolving phlegm and relieving cough, clearing the lungs and resolving phlegm, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem of undiscovered detection methods of Qingjin Zhisou Huatan Pills, qualitative and quantitative control of product internal quality, etc. problem, to achieve the effect of easy quality control, strong specificity and good reproducibility

Inactive Publication Date: 2018-03-09
R & D CENT OF TIANJIN ZHONGXIN PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its quality standard only stipulates the appearance, microscopic identification and thin-layer identification method of rhubarb medicinal materials, which cannot fundamentally control the intrinsic quality of the product qualitatively and quantitatively.
After searching, no patent documents related to the detection method of Qingjin Zhisou Huatan Pills were found

Method used

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  • Quality control method of medicine with functions of clearing lung, eliminating phlegm and suppressing cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Materials

[0036] Test product: Qingjin Zhisou Huatan Wan, Tianjin Zhongxin Pharmaceutical Group Co., Ltd. Lerentang Pharmaceutical Factory, batch numbers: 160801, 160802, 160803.

[0037] Reference substance: Peiminin A reference substance, China National Institutes for Food and Drug Control, batch number 110750-201311,

[0038] Peiminin B reference substance, China National Institutes for Food and Drug Control, batch number 110751-201110

[0039] Control medicinal materials: Zhejiang Fritillaria medicinal materials, China National Institutes for Food and Drug Control, batch number 120972-201405.

[0040] Preparation of negative control substance: Prepare a drug sample without Fritillaria japonicus according to the process and prescription published in the Pharmacopoeia.

[0041] 2. Detection

[0042] 1. Preparation of the test solution: take 5g of the drug to be tested, grind it finely, add 30ml of water to dissolve it, take a water bath to 80°C, adjust the pH ...

Embodiment 2

[0052] 1. Materials

[0053] Test product: Qingjin Zhisou Huatan Wan, Tianjin Zhongxin Pharmaceutical Group Co., Ltd. Lerentang Pharmaceutical Factory, batch numbers: 160801, 160802, 160803.

[0054] Reference substance: Peiminin A reference substance, China National Institutes for Food and Drug Control, batch number 110750-201311,

[0055] Peiminin B reference substance, China National Institutes for Food and Drug Control, batch number 110751-201110

[0056] Control medicinal materials: Zhejiang Fritillaria medicinal materials, China National Institutes for Food and Drug Control, batch number 120972-201405.

[0057] 2. Detection

[0058] 1. Preparation of the test solution: take 5g of the drug to be tested, grind it finely, add 30ml of water to dissolve it, take a water bath to 80°C, adjust the pH value to 2 with 1% hydrochloric acid, centrifuge for 10 minutes, take the supernatant, and dissolve it with 5% hydrochloric acid Adjust the pH value to 11 with sodium hydroxide, ...

Embodiment 3

[0066] 1. Materials

[0067] Test product: Qingjin Zhisou Huatan Wan, Tianjin Zhongxin Pharmaceutical Group Co., Ltd. Lerentang Pharmaceutical Factory, batch numbers: 160801, 160802, 160803.

[0068] Reference substance: Peiminin A reference substance, China National Institutes for Food and Drug Control, batch number 110750-201311

[0069] Peiminin B reference substance, China National Institutes for Food and Drug Control, batch number 110751-201110

[0070] Control medicinal material: Fritillaria fritillaria, China National Institutes for Food and Drug Control, batch number 120972-201405

[0071] 2. Detection

[0072] 1. Preparation of the test solution: take 3g of the drug to be tested, grind it finely, add 20ml of water to dissolve it, take a water bath to 70°C, adjust the pH value to 3 with 0.5% hydrochloric acid, centrifuge, take the supernatant, and dissolve it with 3% sodium hydroxide Adjust the pH to 9, extract twice with ether, 10ml each time, combine the extracts,...

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Abstract

The invention discloses a quality control method of a medicine with functions of clearing lung, eliminating phlegm and suppressing cough, belonging to the field of pharmacy. The quality detection method of the medicine with the functions of clearing lung, eliminating phlegm and suppressing cough comprises the following steps: 1, preparing a test solution, taking the medicine to be tested as the test solution; 2, preparing a reference medicine solution, taking bulbus fritillariae thunbergii medicine to prepare the reference medicine solution; 3, preparing a reference substance solution; 4, carrying out thin layer chromatography: respectively sucking 4ml of the two solutions, then respectively dripping the sucked solutions onto the same silica gel G thin layer plate, spreading by using a developing solvent, taking out the silica gel G thin layer plate, drying in the air, and spraying the silica gel G thin layer plate with a dilute bismuth potassium iodide test solution; 5, carrying out determination of results. A bulbus fritillariae thunbergii thin-layer identification method is established on the original standard basis of Qing jin zhi sou hua tan pills; the method, which is good inreproducibility, strong in specificity, clear in spot developing and easy in determination of results, is screened out and is introduced into the revised quality standard in the standard; therefore,the medicine quality control is improved, the qualitative detection of the medicine is more accurate, and the quality of the medicine is more easily controlled.

Description

technical field [0001] The invention relates to a quality control method of a medicine for clearing lung, resolving phlegm and relieving cough, belonging to the field of pharmacy. Background technique [0002] The prescription of Qingjin Zhisou Huatan Pills uses Scutellaria baicalensis and Trichosanthes root as the main medicines to clear and relieve the syndrome of dryness and heat in the lungs and intestines; Radix chinensis, Platycodon grandiflorum, and Fritillaria chinensis are used as auxiliary ingredients to treat cough due to lung heat and phlegm; bitter almonds, Morus alba Skin and Baibu relieve cough and asthma, Ophiopogon japonicus and Anemarrhena nourishes lung and yin, rhubarb is combined with trichosanthin to relieve heat in the large intestine, and orange and orange shell are used to regulate qi and reduce phlegm, and prevent rhubarb and scutellaria baicalensis from clearing and purging too much, as adjuvant drugs; Licorice harmonizes various medicines. The fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 闫晓楠潘勤王祎孙律衡
Owner R & D CENT OF TIANJIN ZHONGXIN PHARM
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