Feed additive and feed

A feed additive, feed technology, applied in animal feed, additional food elements, applications, etc., can solve the problems of gastrointestinal mucosal ulcers, negative effects, and high coating costs

Inactive Publication Date: 2018-03-30
高海娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the growth-promoting effect of cysteamine on growing and finishing pigs is dose-dependent. Within a certain dose range, with the increase of cysteamine dose in the diet, the effect of increasing daily gain and reducing feed-to-weight ratio is more obvious , but reached or exceeded a certain dose, but it showed a certain negative effect; the reason may be that high doses of cysteamine lowered the pH of gastric juice, thereby causing ulcers
[0006] At present, there are many coating cysteamine manufacturers, and the product quality varies. In the coating process, the product particles required by the feed additives must be small, otherwise they will be mixed unevenly. This puts forward very high requirements for the coating process, and to achieve Requirements, equipment investment is large, coating cost is high, and the current cysteamine has the problem of causing gastrointestinal mucosal ulcers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Add 500kg of dichloromethane and 154kg of cysteamine into a 2000L enamel reaction kettle, cool down to 0-5°C with frozen brine, slowly add 204kg of acetyl chloride (over 30%), and drop 200kg of triethylamine at the same time to maintain the temperature Reaction at 0-5°C, when no cysteamine can be detected, stop the reaction, raise the temperature to 38-45°C, distill out dichloromethane for recovery (recycling), add 1000kg of cold water, and separate 200kg of N-acetylcysteamine , detected by liquid chromatography, the content was 99.1% (N-acetyl cysteamine standard sample was purchased from SIGMA, USA), and the yield was 97.9%.

Embodiment 2

[0032] Add 500kg of dichloromethane and 154kg of cysteamine into a 2000L enamel reaction kettle, cool down to 0-5°C with frozen brine, slowly add 277kg of butyryl chloride (over 30%), and dropwise add 200kg of triethylamine to keep the temperature Reaction at 0-5°C, when no cysteamine can be detected, stop the reaction, raise the temperature to 38-45°C, distill out dichloromethane for recovery (recycling), add 1000kg of cold water, and separate 255kg of N-butyryl cysteamine , detected by liquid chromatography, the content was 99.4% (N-butyryl cysteamine standard sample was purchased from SIGMA, USA), and the yield was 98.1%.

Embodiment 3

[0034]Add 500kg of dichloromethane and 154kg of cysteamine into a 2000L enamel reaction kettle, cool down to 0-5°C with frozen brine, slowly add 782kg of oleoyl chloride (over 30%), and drop 200kg of triethylamine at the same time to maintain the temperature Reaction at 0-5°C, when no cysteamine can be detected, stop the reaction, raise the temperature to 38-45°C, slip out the dichloromethane for recovery (recycling), add 1000kg of cold water, and separate 635kg of N-oleoyl cysteamine , detected by liquid chromatography, the content was 98.2% (N-oleoyl cysteamine standard sample was purchased from SIGMA, USA), and the yield was 96.3%.

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PUM

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Abstract

The present application provides a feed additive, which includes N-acyl cysteamine compounds, and the N-acyl cysteamine compounds provided in the present application are preferably obtained by reacting cysteamine and acid chlorides. The application also provides a feed. In the feed of the present application, N-acyl cysteamine compounds are added, which use acyl as the protecting group of cysteamine, so that N-acyl cysteamine compounds are not irritating and will not cause gastrointestinal mucosal ulcers. Under the action of pancreatic lipase, it slowly decomposes into cysteamine and acts as an animal growth promoter, which can promote animal growth and development, increase weight gain and feed conversion rate.

Description

technical field [0001] The invention relates to the technical field of feed, in particular to feed additives and feed. Background technique [0002] Cysteamine, also known as β-mercaptoethylamine, is the decarboxylation product of cysteine ​​and is a component of coenzyme A molecule. Cysteamine can specifically reduce the biological activity of somatostatin SS, regulate the secretion of hormones such as growth hormone, insulin, glucagon, thyroid hormone and T4, thereby regulating the metabolism of nutrients such as protein, fat and carbohydrates. Due to the existence of -SH and -NH2 groups in cysteamine, it is very easy to be oxidized in the air. Therefore, cysteamine is generally prepared in the form of hydrochloride or coated into microcapsules and mixed directly in the feed. Piglet survival rate and growth rate, and will have a positive impact on future performance. [0003] Studies have shown that adding 100-150mg / kg cysteamine to piglet diet can relieve piglet weaning...

Claims

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Application Information

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IPC IPC(8): A23K20/142
CPCA23K20/142
Inventor 高海娟
Owner 高海娟
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