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Method for detecting polyvinylpyrrolidone content in contact lenses caring composition

A technology of polyvinylpyrrolidone and contact lenses, applied in the field of chemical analysis and detection, to achieve high accuracy, small result error and eliminate interference

Inactive Publication Date: 2018-04-06
HAICHANG CONTACT LENSES +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adopt ultraviolet absorption spectrometry to quantitatively measure the content of polyvinylpyrrolidone in the contact lens care composition and there is no report so far

Method used

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  • Method for detecting polyvinylpyrrolidone content in contact lenses caring composition
  • Method for detecting polyvinylpyrrolidone content in contact lenses caring composition
  • Method for detecting polyvinylpyrrolidone content in contact lenses caring composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Contact lens care solution sample A

[0069] ①Ingredient: sodium chloride (5.0mg / mL), boric acid (3.0mg / mL), borax (0.80mg / mL), potassium chloride (0.5mg / mL), poloxamer (1.5mg / mL), EDTA·2Na (1.1mg / mL), sodium citrate (0.10mg / mL), propylene glycol (0.200mg / mL), PVP (1.00mg / mL), hydroxypropyl methylcellulose (0.10mg / mL), Glycerin (1.0mg / mL), PHMB (0.0010mg / mL), ALDOX (0.0050mg / mL)

[0070] ② quasi-curve

[0071] y=9.5762x+0.0264R 2 =0.999

[0072] ③Sample measurement results

[0073] PVP test result in table 4 contact lens care solution sample A

[0074]

[0075]

Embodiment 2

[0077] Contact lens care solution sample B

[0078] ①Ingredient: sodium chloride (5.5mg / mL), boric acid (4.0mg / mL), borax (1.0mg / mL), EDTA·2Na (0.50mg / mL), poloxamer (1.0mg / mL), Mannitol (3.00mg / mL), trehalose (2.00mg / mL), PVP (0.500mg / mL), sodium hyaluronate (0.100mg / mL), chitosan quaternary ammonium salt (0.30mg / mL)

[0079] ②Standard curve

[0080] y=9.816x+0.013R 2 =0.999

[0081] ③Sample measurement results

[0082] PVP test result in table 5 contact lens care solution sample B

[0083]

Embodiment 3

[0085] Contact lens care solution sample C

[0086] ①Ingredient: sodium chloride (5.5mg / mL), boric acid (3.0mg / mL), borax (0.30mg / mL), EDTA·2Na (1.0mg / mL), thiobetaine (3.00mg / mL), PVP (0.0100mg / mL), poloxamer (1.5mg / mL), polyalkoxyethylenediamine (2.0mg / mL), nonanoylethylenediaminetriacetic acid (2.00mg / mL), PAPB (0.0010 mg / mL), PQ-1 (0.0010mg / mL)

[0087] ②Standard curve

[0088] y=10.531x-0.005R 2 =0.999

[0089] ③Sample measurement results

[0090] PVP test result in table 6 contact lens care solution sample C

[0091]

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Abstract

The invention relates to a method for detecting polyvinylpyrrolidone content in a contact lenses caring composition. The method comprises the following steps: respectively preparing a stock solution,a blank stock solution, and a caring composition standard stock solution, using a linear relation of an absorption value y and concentration x of polyvinylpyrrolidone under different concentrations todetermine the polyvinylpyrrolidone concentration in the nursing composition, which is pretreatment of the to-be-measured caring composition, determining polyvinylpyrrolidone concentration in the to-be-measured caring composition, taking the blank stock solution as a blank solvent and a reference solution respectively to obtain an ultra-violet absorption curve y=ax+b of the to-be-measured caring composition corresponding to an ultra-violet absorption wavelength, taking a ultra-violet absorption value of the to-be-measured caring composition, and substituting the ultra-violet absorption value into the standard curve of the polyvinylpyrrolidone concentration in the caring composition to obtain the polyvinylpyrrolidone concentration in the to-be-measured contact lens caring composition. The method has the advantages of simpleness and rapidity, low detection limit, and sensitive and stable signal, and can satisfy detection requirement.

Description

technical field [0001] The invention belongs to the field of chemical analysis and detection, in particular to a method for detecting the content of polyvinylpyrrolidone in a contact lens care composition. Background technique [0002] Polyvinylpyrrolidone is a water-soluble amide polymer. Due to its excellent solubility, film-forming property, complexation property and certain surface activity, it is widely used in medicine, daily chemicals, food, textile, printing and dyeing, Widely used in many industrial fields such as coatings. Polyvinylpyrrolidone is odorless, tasteless, almost non-toxic, non-irritating to skin and eyes, and has no skin sensitization. [0003] As a non-ionic polymer compound, polyvinylpyrrolidone has been widely concerned and applied because of its excellent solubility, low toxicity and good biocompatibility. Polyvinylpyrrolidone is used in contact lens care products mainly to improve their lubricity. [0004] The qualitative identification of polyv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/33
CPCG01N21/33
Inventor 祁争健吴保嬴周冰瑶陈平韩雪莲束伟霞束鹤亭
Owner HAICHANG CONTACT LENSES
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