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Anti-influenza virus function of flavaspidic acid AB

A technology of influenza virus and fumaric acid, applied in the direction of antiviral agents, organic active ingredients, medical preparations containing active ingredients, etc., to prevent and treat infection and protect human health

Inactive Publication Date: 2018-04-17
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The RNA-dependent RNA polymerase inhibitor, Favipiravir, is only allowed to treat influenza in Japan, but its application is still strictly controlled

Method used

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  • Anti-influenza virus function of flavaspidic acid AB
  • Anti-influenza virus function of flavaspidic acid AB
  • Anti-influenza virus function of flavaspidic acid AB

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1, the application of fumaic acid AB in suppressing influenza virus

[0055] 1. Acquisition of fumaric acid AB

[0056] Dried 8000g of Mianma Guanzhong medicinal material, pulverized, refluxed and extracted 3 times with 90% ethanol aqueous solution by volume, each time for 1 hour, the temperature of each reflux was 50°C, and the filtrates were combined. Concentrate the filtrate under reduced pressure to recover ethanol to obtain the crude extract of fumaric acid AB.

[0057] Put the above-mentioned crude extract of AB of fumaric acid mixed with diatomaceous earth (volume ratio 1:1) into a glass chromatography column (20*80cm), and then use n-hexane (4L), chloroform (4L), acetone (4L) and ethanol (4L) to elute into four fractions, collect the eluate from each fraction, and concentrate to dryness under reduced pressure.

[0058] The n-hexane eluted product was chromatographed on a silica gel glass column (8*100cm), hexane-acetone gradient elution (volume rati...

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Abstract

The invention discloses an anti-influenza virus function of flavaspidic acid AB. The invention provides application of the flavaspidic acid AB in preparation of at least one of the following products1)-5): 1) an influenza virus inhibitor; 2) a product for treating influenza; 3) a product for inhibiting proliferation or replication of influenza viruses; 4) a product for inhibiting synthesis of influenza virus RNA; and 5) a product for inhibiting expression or synthesis of a gene in the influenza virus. Experiments prove that the flavaspidic acid AB is extracted from male fern rhizome, the flavaspidic acid AB is a monomer compound from plants, and the flavaspidic acid AB can be used for preparing the influenza virus inhibitor, so that the flavaspidic acid AB is used for preventing and treating infection of influenza, human health is protected, and a new choice is provided for development of an influenza virus drug.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to the anti-influenza virus function of fumaric acid AB. Background technique [0002] Influenza viruses are enveloped, segmented, single-stranded, negative-sense RNA viruses belonging to the family Orthomyxoviridae and the genus Influenzavirus. According to the antigenicity of the viral nucleoprotein, influenza viruses are divided into three subtypes: A (A), B (B) and C (C). The natural hosts of type A influenza viruses are waterfowl and birds, and they can be obtained from natural hosts. Passed to poultry, horses, pigs and humans. Influenza A virus can cause a global pandemic with high morbidity and mortality. There are two ways in which a pandemic virus can be produced. One is that the avian influenza virus infects humans and causes disease (bird flu). In this process, the avian influenza virus The second is the genetic recombination between the popular seasonal influen...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P31/16
CPCA61K31/122
Inventor 曹丽高丽马国需
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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