Sperm pirna and sperm protein mitopld as biomarkers for detection and prediction of male infertility

A technology of sperm biology and markers, applied in the biological field, can solve problems such as retrotransposon demethylation, de-inhibition of primary piRNA barriers, reproductive barriers, etc., to reduce pain, improve accuracy, and facilitate sample processing and detection Effect
CN107916289BActive Publication Date: 2020-04-24南京碳硅人工智能生物医药技术研究院有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
南京碳硅人工智能生物医药技术研究院有限公司
Publication Date
2020-04-24

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Abstract

The invention discloses a sperm piRNA and a sperm protein MitoPLD as biomarkers for detecting and predicting male infertility. The biomarkers include 10 piRNAs (mainly piR-1207 and piR-2107) and the MitoPLD protein. The piRNA combination and the MitoPLD protein can be used for detection and prediction of sperm motility. According to the sperm piRNA and the sperm protein MitoPLD as the biomarkers for detecting and predicting the male infertility, spermatozoa are more easily obtained without other tissues, and the sperm piRNA and the sperm protein MitoPLD as the biomarkers for detecting and predicting the male infertility belong to non-invasive examination; the sperm piRNA and the MitoPLD protein can reflect pathological and physiological conditions throughout spermatogenesis at a molecularlevel, and are used as an auxiliary detection index to improve accuracy of detection, and provide potential targets for treatment of male reproductive dysfunction.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and relates to sperm piRNA and sperm protein MitoPLD as biomarkers for detecting and predicting male infertility. Background technique

[0002] Infertility has become a worldwide reproductive health problem. Currently, more than 15% of couples in the world suffer from infertility problems (1,2). Among them, about 20% to 30% of infertility is caused by male factors alone, and 50% of infertility is related to male factors. In recent years, this data has been on the rise (2,3), so male infertility Infertility plays an important role, however, the molecular mechanism of male infertility is not fully understood (4,5). At present, the clinical reproductive laboratory inspection items generally include biochemical inspection of semen, acid phosphatase, lactate dehydrogenase-X and other enzyme inspections, and semen immunological inspection, but these technologies have some defects and cannot directly refl...

Claims

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