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Treatment method of tetracycline crystal mother liquor

A technology of crystallization mother liquor and treatment method, which is applied in the field of treatment of tetracycline crystallization mother liquor, can solve the problems of difficult biochemical treatment of tetracycline crystallization mother liquor, high treatment cost, low treatment efficiency, etc., and achieves the advantages of easy biochemical treatment, volume reduction and increased benefit Effect

Inactive Publication Date: 2018-04-20
NINGXIA QIYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large amount of mother liquor is produced in the crystallization process of tetracycline. Due to the relationship of solubility, a certain amount of tetracycline remains in the mother liquor of tetracycline, which is generally discharged directly as waste liquid or treated by direct four-effect evaporation of mother liquor of tetracycline, and then discharged after biochemical treatment. About 1000u / ml of tetracycline remains in the tetracycline mother liquor, and the maximum tolerance concentration of anaerobic bacteria to tetracycline is 300u / ml. It is difficult to enter the tetracycline crystallization mother liquor into biochemical treatment, and the treatment efficiency is low, so pretreatment is required, and the overall treatment cost higher

Method used

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  • Treatment method of tetracycline crystal mother liquor
  • Treatment method of tetracycline crystal mother liquor

Examples

Experimental program
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Effect test

Embodiment 1

[0014] Take 8L of tetracycline crystallization mother liquor, add 80g of solid calcium hydroxide, stir for 10min, add 160ml of polyaluminum chloride solution with a concentration of 40%, stir for 12min, add 80ml of anionic polyacrylamide solution with a concentration of 0.2%, stir slowly for 5min, and filter through a double layer Cloth (inner 621, outer 758) plate and frame filtration to obtain 7L filtrate, take 10L of tetracycline fermentation broth, measure its potency unit as 30000u / ml, add 5L of filtrate to dilute, carry out acidification and release, and the titer of acidification solution is 19980u / ml, Ceramic membrane filtration, crystallization.

Embodiment 2

[0016] Take 10L of tetracycline crystallization mother liquor, add 100g of solid calcium hydroxide, stir for 12min, add 200ml of polyaluminium chloride solution with a concentration of 40%, stir for 13min, add 100ml of anionic polyacrylamide solution with a concentration of 0.2%, stir slowly for 5min, and filter through a double layer Cloth (inner 621, outer 758) plate and frame filtration to obtain 9L filtrate, take 10L of tetracycline fermentation broth, measure its titer unit as 30000u / ml, add 5.8L of filtrate to dilute, carry out acidification and release, and the titer of acidification solution is 19334u / ml , ceramic membrane filtration, separation liquid crystallization.

Embodiment 3

[0018] Take 15L of tetracycline crystallization mother liquor, add 150g of solid calcium hydroxide, stir for 15min, add 300ml of polyaluminum chloride solution with a concentration of 40%, stir for 15min, add 150ml of anionic polyacrylamide solution with a concentration of 0.2%, stir slowly for 5min, and filter through a double layer Cloth (inner 621, outer 758) plate and frame filter to obtain 13.5L filtrate, take 10L of tetracycline fermentation broth, measure its potency unit as 30000u / ml, add 6.7L of filtrate to dilute, carry out acidification and release, and the titer of acidification solution is 18021u / ml ml, filtered by ceramic membrane, crystallized.

[0019] Below is the detection data of above-mentioned embodiment 1,2 and 3:

[0020]

[0021] Table 1: Comparison data of potency and COD before and after treatment with tetracycline mother liquor

[0022] Table 2: Quality of Crystalline Products

[0023]

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Abstract

The invention relates to a treatment method of tetracycline crystal mother liquor. The process comprises the steps: the tetracycline crystal mother liquor with the pH of 4.6-4.8 is pretreated with calcium hydroxide, a polyaluminum chloride solution and an anionic polyacrylamide solution in turn and then is filtered by a plate frame, and the obtained filtrate is added to a tetracycline fermentationliquid, and extraction preparation of a tetracycline finished product is carried out. The tetracycline crystal mother liquor is pretreated, and then the pretreated tetracycline crystal mother liquoris used as dilution water released from acidification of the tetracycline fermentation liquid for reuse; on one hand, the volume of the tetracycline mother liquor can be reduced, use of primary wateris reduced, and benefits are increased; one the other hand, the content of antibiotics in the tetracycline crystal mother liquor is reduced, the tetracycline crystal mother liquor is more easily treated by a biochemical method, the pressure of environmental protection treatment is alleviated, and the effect is remarkable. The quality of the produced finished product conforms to the quality standard.

Description

technical field [0001] The invention belongs to the technical field of biology and new medicine, in particular to a method for treating tetracycline crystallization mother liquor. Background technique [0002] Tetracycline is a class of broad-spectrum antibiotics produced by actinomycetes. It has a good inhibitory effect on Gram-positive bacteria, negative bacteria, rickettsia, viral viruses, spirochetes and even protozoa, and has a good inhibitory effect on tuberculosis. Bacteria, proteus, etc. are invalid. Its mechanism of action is that after binding to the 30S subunit of the ribosome, it can prevent aminoacyl tRNA from binding to the ribosome. [0003] In the prior art, the production method of tetracycline is to obtain the filtrate after acidification and filtration of the tetracycline fermentation liquid, crystallize the filtrate to obtain tetracycline, separate and dry to obtain tetracycline finished product. A large amount of mother liquor is produced in the crysta...

Claims

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Application Information

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IPC IPC(8): C07C231/24C07C237/26
CPCC07C231/24C07C237/26
Inventor 马晓军孙瑞君罗江涛鲍晶张志
Owner NINGXIA QIYUAN PHARMA
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