Amlodipine besylate tablet and preparation method thereof
A technology of amlodipine besylate tablets and magnesium stearate, which is applied in the field of medicine, can solve the problems of reduced drug efficacy, low yield, and easy accumulation into agglomerates, so as to improve content uniformity and dissolution rate, and reduce aggregation effect, the effect of ensuring dissolution rate
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[0054] A kind of amlodipine besylate tablet, this amlodipine besylate tablet comprises the following components by weight percentage:
[0055]
[0056] In the amlodipine besylate tablet of this embodiment, the particle diameter of anhydrous calcium hydrogen phosphate in the selected components is D10=28 μm, D90=100 μm, and the particle diameter of microcrystalline cellulose is D10=29 μm, D90=136 μm , the particle size of sodium carboxymethyl starch is D10=38 μm, D90=171 μm, the particle size of magnesium stearate (including internally added magnesium stearate and externally added magnesium stearate) is D10=38 μm, D90=159 μm, fine powder The particle size of silica gel is D10=28 μm, D90=127 μm, the particle size of amlodipine besylate is D10=28 μm, D90=125 μm.
[0057] The preparation method of the amlodipine besylate sheet of the present embodiment may further comprise the steps:
[0058] (1) Take the raw and auxiliary materials in the above formula, first mix amlodipine b...
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