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Method for mixedly and catalytically synthesizing triglyceride of medium-long-chain structure

A technology of structural triglycerides and long-chain triglycerides, which is applied in the field of hybrid catalytic synthesis of medium and long-chain structural triglycerides, can solve the problems of excessive by-products such as diglycerides and low yield of target products, and achieve the goal of reaction The post-treatment is simple, the conditions are mild, and the effect of reducing catalytic steric hindrance

Active Publication Date: 2018-05-01
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for synthesizing triglycerides with a medium and long chain structure by mixed catalysis, and solve the technical problems of low yield of target products and excessive by-products such as diglycerides in the production process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Mix 6.4kg soybean oil (long carbon chain triglyceride) with 3.6kg caprylic triglyceride (medium carbon chain triglyceride), add to a closed container, add 4% (based on oil weight) of Lipozyme TL IM Stir and heat the reaction under vacuum in a water bath at 70°C for 1 hour, with a stirring rate of 400r / min. After the reaction is completed, double-layer filter paper is vacuum-filtered to obtain a product containing triglycerides with a medium-long chain structure. After HPLC analysis, the glycerol with a medium-long chain structure Triglyceride content reaches 73.85%, and diglyceride content reaches 18.33%.

Embodiment 2

[0022] Mix 6.4kg soybean oil (long-chain triglycerides) with 3.6kg caprylic triglycerides (medium-carbon chain triglycerides), add them to a closed container, preheat at 70°C for 10 minutes, and then add 4% ( Lipozyme TL IM (according to oil weight) and 0.5% oleic acid saturated activated alumina (containing acid) were stirred and heated in a vacuum at 70°C for 1 hour in a water bath, and the stirring rate was 400r / min. After the reaction was completed, the double-layer filter paper was vacuum filtered , to obtain the product containing triglycerides of medium and long chain structure, through HPLC analysis, the content of triglycerides of medium and long chain structure reaches 78.15%, and the content of diglycerides is only 6.72%.

Embodiment 3

[0024] Mix 6.4kg rapeseed oil (long-chain triglycerides) with 3.6kg caprylic triglycerides (medium-carbon chain triglycerides), add them to a closed container, preheat at 50°C for 10 minutes, and then add 3% (in the form of Oil weight meter) Lipozyme TL IM and 1% acidic alumina were stirred and heated in a vacuum at 50°C for 1 hour in a water bath at a stirring rate of 500r / min. The product of triglyceride, through HPLC analysis, the content of triglyceride with medium and long chain structure reaches 79.24%, and the content of diglyceride is only 6.24%.

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Abstract

The invention discloses a method for mixedly and catalytically synthesizing triglyceride of a medium-long-chain structure. The method comprises the following steps: mixing long-chain triglyceride withmedium-chain triglyceride according to a mass ratio of 1 to (0.1 to 3), preheating under a solvent-free system, meanwhile adding lipase and acid saturated aluminum oxide, vacuum stirring to perform heating reaction and reducing pressure and performing suction filtration to obtain a product containing the triglyceride of the medium-long-chain structure. The catalytic synthesis ester exchange method disclosed by the invention has the advantages of quick reaction speed, high conversion rate, small diglyceride byproduct, moderate reaction, simple aftertreatment, high efficiency, quickness, greenness, environmental friendliness, suitability for industrial large-scale popularization and great social benefit.

Description

technical field [0001] The invention belongs to the technical field of oil synthesis, and in particular relates to a method for synthesizing triglycerides with a medium and long chain structure through mixed catalysis. Background technique [0002] Medium and long-chain fatty acid structure triglyceride (MLCT), is a new type of functional oil obtained by combining medium and long-chain fatty acids on triglycerides. It is synthesized by transesterification or esterification. It also contains medium-chain fatty acids (MCFA, 8-12 carbon fatty acids) and long-chain fatty acids (LCFA, 14-22 carbon fatty acids). Medium and long-chain triglycerides have the characteristics of being directly absorbed by the human vein into the liver to quickly replenish energy and nutrition for the body, without burdening the intestinal tract, and can effectively reduce the concentration of total cholesterol and low-density lipoprotein, and play a role in weight loss and prevention. Treatment of di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/64
CPCC12P7/6445
Inventor 蔡鸿飞许文东唐顺之关伟键江程牟肖男龙海林刘菊妍吴伟锋王小妹杨阳李海波李康强潘裕清
Owner GUANGZHOU HANFANG PHARMA
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