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A drug combination for preventing and treating animal echinococcosis and its application

A technology for echinococcosis and animals, which is applied in the field of veterinary compound Chinese medicine, can solve the problems of animal product residues, food safety, serious drug resistance, etc., achieve the effects of high prevention and cure rate, prevent drug resistance, and reduce dosage

Active Publication Date: 2020-03-20
WUHAN ACADEMY OF AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical commonly used drugs are relatively single, mainly praziquantel and albendazole, the deworming effect is not ideal, the use time is long, easy to relapse after drug withdrawal, serious drug resistance, resulting in serious impact on animal production performance; large doses of drugs The use not only has a toxic effect on the body, but also easily causes residues in animal products, which brings food safety problems

Method used

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  • A drug combination for preventing and treating animal echinococcosis and its application
  • A drug combination for preventing and treating animal echinococcosis and its application
  • A drug combination for preventing and treating animal echinococcosis and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A Chinese and Western medicine compound preparation for preventing and treating animal echinococcosis is extracted and prepared according to the following scheme:

[0026] Arecoline extraction: crush 100g arecoline, pass through a 50-mesh sieve, heat and reflux with 85v / v% ethanol with a ratio of 14mL:1g to arecoline for 1.5h, filter the extract, and extract the residue twice as above. Combine the extracts for 3 times, concentrate under reduced pressure to recover ethanol, place the remaining concentrated solution to cool to room temperature, add ammonia water to adjust to pH=8, stir and extract with carbon tetrachloride three times, combine the extracts for three times with anhydrous sodium sulfate Dry, then concentrate under reduced pressure on a 60°C water bath, dry and pulverize to obtain 0.3 g of arecoline.

[0027] Cucurbitine extraction: crush 200g pumpkin seeds, pass through a 50-mesh sieve, use 3 times the volume of n-hexane to degrease twice, filter and dry to...

Embodiment 2

[0031] A Chinese and Western medicine compound preparation for preventing and treating animal echinococcosis is extracted and prepared according to the following scheme:

[0032] Extract arecoline, squash, and osthole according to the preparation method of Example 1, with praziquantel 20g, arecoline 3g, squash 60g, osthole 18g, maltose 20g, palm oil 2g, citric acid 50g, 30g of malic acid and 50g of starch are uniformly mixed and granulated into granules to obtain final product.

Embodiment 3

[0034] A Chinese and Western medicine compound preparation for preventing and treating animal echinococcosis is extracted and prepared according to the following scheme:

[0035]Extract arecoline, squash, and osthole according to the preparation method of Example 1, with 5 g of praziquantel, 0.1 g of arecoline, 2 g of squash, 0.3 g of osthole, 5 g of maltose, and 0.5 g of palm oil , citric acid 20g, malic acid 6g and starch 10g are mixed evenly and then granulated into granules to obtain final product.

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Abstract

The invention relates to the technical field of composite formulae of traditional Chinese medicines and western medicines for livestock and in particular discloses a traditional Chinese medicine and western medicine composite preparation as well as a preparation method and an application thereof. The traditional Chinese medicine and western medicine composite preparation provided by the inventionis prepared from praziquantel, arecoline, cucurbitin, osthole and the like according to a certain ratio by using certain processes. The medicinal composition provided by the invention is simple and clear in method, easy to apply, remarkable in treatment effect due to the combination of traditional Chinese medicines and western medicines, and applicable to prevention and treatment on animal echinococcoses, and has relatively good economic benefits and social benefits.

Description

technical field [0001] The invention relates to the technical field of veterinary compound Chinese medicine, in particular to a Chinese and Western medicine compound preparation for preventing and treating animal echinococcosis and its preparation method and application. Background technique [0002] Echinococcosis is a zoonotic disease caused by the larvae of Echinococcus tapeworm parasitizing in the liver, lung, brain and other organs of animals and humans. Dogs are the final hosts, and sheep and cattle are intermediate hosts. The insect-eating eggs become intermediate hosts and suffer from echinococcosis. The Ministry of Agriculture listed it as a second-class animal disease, and the Health and Family Planning Commission listed it as a class-C infectious disease. According to the relevant data of the World Health Organization, the 10-year mortality rate of untreated alveolar echinococcosis patients reaches 94%, which is called "worm cancer". Livestock infected with echin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4985A61K31/455A61K31/37A61K31/40A61P33/10
CPCA61K31/37A61K31/40A61K31/455A61K31/4985A61K2300/00
Inventor 何斌边巴次仁刘武常瑛陈洁尼玛仓决姚艳丰杨文海赤列旺久陶弼菲曲珍华娟措姆措吉
Owner WUHAN ACADEMY OF AGRI SCI
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