Method for repairing bone tissue by utilizing 3D printing double-component hydrogel

A 3D printing and hydrogel technology, used in tissue regeneration, medical science, prosthesis, etc., can solve the problems of inability to achieve precise and dense bone repair, slow curing of repaired bone, hindering the healing of bone damage, etc. Curing rate and adhesion properties, dense bone repair, effect of enhancing effect

Active Publication Date: 2018-05-08
山东明河药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] For the currently widely used 3D printing bone tissue molding scheme, it is difficult to effectively hot-melt bond the material, resulting in slow curing of the repaired bone, poor adhesion, and poor biocompatibility, which makes it impossible to achieve precise and dense bone

Method used

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  • Method for repairing bone tissue by utilizing 3D printing double-component hydrogel
  • Method for repairing bone tissue by utilizing 3D printing double-component hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The two-component hydrogel is composed of hydrogel A and hydrogel B;

[0040] The mass ratio of hydrogel A and hydrogel B used for printing is 4:3;

[0041]In hydrogel A, each component is: methacryloyl glycinamide hydrogel 45kg, monetite 13kg, calcium sulfate 15kg, nonionic surfactant 0.4kg, ethyl acetate 26.6kg;

[0042] In hydrogel B, each component is: silica gel 28kg, silicic acid 22kg, polylactic acid short fiber 28kg, zwitterionic surfactant 0.4kg, ethanol 21.6kg;

[0043] The nonionic surfactant is coconut oil glucoside; the short polylactic acid fiber is poly d-lactic acid fiber; the zwitterionic surfactant is lecithin;

[0044] The preparation process is:

[0045] (1) In a high-speed mixer, use non-ionic surfactants to treat monetite and calcium sulfate on the surface, add them to ethyl acetate after discharging, stir and disperse evenly, and then mix with methacryloylglycine The amide hydrogel is mixed to obtain stable hydrogel A; the high-speed mixer is a...

Embodiment 2

[0050] The two-component hydrogel is composed of hydrogel A and hydrogel B;

[0051] The mass ratio of hydrogel A and hydrogel B used for printing is 3:2;

[0052] In hydrogel A, each component is: methacryloyl glycinamide hydrogel 40kg, monetite 10kg, calcium sulfate 14kg, nonionic surfactant 0.5kg, ethyl acetate 35.5kg;

[0053] In hydrogel B, each component is: silica gel 22kg, silicic acid 18kg, polylactic acid short fiber 28kg, zwitterionic surfactant 0.2kg, ethanol 31.8kg;

[0054] The nonionic surfactant is lauryl glucoside; the short polylactic acid fiber is poly L-lactic acid fiber; the zwitterionic surfactant is an amino acid active agent;

[0055] The preparation process is:

[0056] (1) In a high-speed mixer, use non-ionic surfactants to treat monetite and calcium sulfate on the surface, add them to ethyl acetate after discharging, stir and disperse evenly, and then mix with methacryloylglycine The amide hydrogel is mixed to obtain stable hydrogel A; the high-sp...

Embodiment 3

[0061] The two-component hydrogel is composed of hydrogel A and hydrogel B;

[0062] The mass ratio of hydrogel A and hydrogel B used for printing is 4:3;

[0063] In hydrogel A, each component is: methacryloyl glycinamide hydrogel 50kg, monetite 15kg, calcium sulfate 17kg, nonionic surfactant 0.4kg, ethyl acetate 17.6kg;

[0064] In hydrogel B, each component is: silica gel 30kg, silicic acid 26kg, polylactic acid short fiber 30kg, zwitterionic surfactant 0.4kg, ethanol 13.68kg;

[0065] The nonionic surfactant is cetearyl glucoside; the short polylactic acid fiber is poly dL-lactic acid fiber; the zwitterionic surfactant is a betaine type active agent;

[0066] The preparation process is:

[0067] (1) In a high-speed mixer, use non-ionic surfactants to treat monetite and calcium sulfate on the surface, add them to ethyl acetate after discharging, stir and disperse evenly, and then mix with methacryloylglycine The amide hydrogel is mixed to obtain stable hydrogel A; the hi...

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Abstract

The invention provides a method for repairing a bone tissue by utilizing 3D printing double-component hydrogel. The method comprises the following steps: spraying out hydrogel A and hydrogel B througha double-spray-head 3D printer, and performing reaction to generate calcium silicate in situ in a deposition process, thereby realizing bone repair; the hydrogel A is prepared from the following components in parts by weight: 40-50 parts of methacryloyl glycinamide hydrogel, 10-15 parts of monetite, 13-18 parts of calcium sulfate, 0.3-0.6 part of a nonionic surfactant and 16.4-36.7 parts of ethylacetate; and the hydrogel B is prepared from the following components in parts by weight: 22-30 parts of silicon dioxide gel, 18-26 parts of silicic acid, 25-32 parts of polylactic acid staples, 0.2-0.5 part of a zwitterionic surfactant and 11.5-34.8 parts of ethanol. The method can effectively realize precise and compact bone repair through reactive crystallization of the double-component gel which can be stored for a long time independently, is high in curing rate of repaired bones, is good in adhesion property, is good in biocompatibility, and greatly improves the bone injury heal effect;and moreover, the whole repair method is simple to operate, adopts easily available raw materials, is low in cost, and can be popularized and applied.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to repairing bone tissue by 3D printing, and in particular to a method for repairing bone tissue by using 3D printing two-component hydrogel. Background technique [0002] The key to clinical treatment of bone defects caused by trauma, tumors, tuberculosis and congenital developmental deformities is to repair the defective bone tissue and restore normal structure and function. Traditional bone tissue repair includes autologous bone grafting, allograft bone implantation, metal stent or prosthetic implantation, etc. Conventional orthopedic implant materials include metals and non-metals. Metals are mostly used for joints or internal fixation. At present, stainless steel, cobalt-chromium-molybdenum alloys, titanium and titanium alloys are mostly used. The above-mentioned traditional treatments all have disadvantages such as incapable of individualized shaping, stress deformation, and ...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/12A61L27/02A61L27/18A61L27/50B33Y10/00B33Y70/00
CPCA61L27/025A61L27/12A61L27/16A61L27/18A61L27/50A61L2430/02B33Y10/00B33Y70/00C08L33/24C08L67/04
Inventor 陈庆曾军堂
Owner 山东明河药业有限公司
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